3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE

Base Information

• Chemical Name: 3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE
• CAS No.: 20442-66-4
• Molecular Formula: C16H12O2
• Molecular Weight: 236.27
• Hs Code.: 2914509090
• Mol file: 20442-66-4.mol

Synonyms:3-(4-methoxyphenyl)-1-phenyl-2-propynone;1-phenyl-3-(4-methoxyphenyl)prop-2-yn-1-one;3-(4-methoxyphenyl)-1-phenylprop-2-ynone;Phenyl p-methoxyphenylethynyl ketone;3-(4-methoxyphenyl)-1-phenyl-prop-2-yn-1-one;3-(4-methoxyphenyl)-1-phenylpropyn-1-one;3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE;AmbscL34/TU-147;3-(4-methoxyphenyl)-1-phenyl-2-propyn-1-one;2-propyn-1-one,3-(4-methoxyphenyl)-1-phenyl;

Chemical Property of 3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE

Chemical Property:

• PSA: 26.30000
• LogP: 2.92960

Purity/Quality:

99% ^*data from raw suppliers

3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE

There total 58 articles about 3-(4-METHOXY-PHENYL)-1-PHENYL-PROPYNONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzoyl chloride (98-88-4) + 4-methoxyphenylacetylen (768-60-5) → 3-(4-methoxyphenyl)-1-phenylprop-2-yn-1-one (20442-66-4)

Guidance literature:

With copper(l) iodide; sodium dodecyl-sulfate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; at 65 ℃; for 4h;

DOI:10.1021/ol048789w

Reference yield: 96.0%

iodobenzene (591-50-4) + carbon monoxide (201230-82-2) + 4-methoxyphenylacetylen (768-60-5) → 3-(4-methoxyphenyl)-1-phenylprop-2-yn-1-one (20442-66-4)

Guidance literature:

With 1 wt% PdCl₂(CH₃CN)₂/Zr₆O₄(OH)₄(2,2′-bipyridine-5,5′-dicarboxylate)₆; caesium carbonate; In N,N-dimethyl-formamide; at 99.84 ℃; for 3h; under 760.051 Torr; chemoselective reaction; Schlenk technique; Sealed tube;

DOI:10.1039/c4cy00488d

Reference yield: 92.0%

benzaldehyde (100-52-7) + 4-methoxyphenylacetylen (768-60-5) → 3-(4-methoxyphenyl)-1-phenylprop-2-yn-1-one (20442-66-4) + benzyl alcohol (100-51-6,185532-71-2)

Guidance literature:

With triethylamine; zinc(II) iodide; In toluene; at 80 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4cc08152h

upstream raw materials:

(benzoyliodomethyl)triphenylphosphonium iodide

4-methoxy-benzaldehyde

carbon monoxide

para-iodoanisole

Downstream raw materials:

5-(4-methoxyphenyl)-3-phenylisoxazole

3-(4-methoxyphenyl)-5-phenylisoxazole

[2-(di-morpholin-4-yl-methylene)-5-(4-methoxy-phenyl)-[1,3]dithiol-4-yl]-phenyl-methanone

(Z)-3-(4-Methoxy-phenyl)-1-phenyl-3-p-tolylsulfanyl-propenone