9-(4-Chlorophenyl)acridine

Base Information

• Chemical Name: 9-(4-Chlorophenyl)acridine
• CAS No.: 20953-66-6
• Molecular Formula: C19H12ClN
• Molecular Weight: 289.764
• DSSTox Substance ID: DTXSID50549358
• Nikkaji Number: J691.935I
• Wikidata: Q82428384
• Mol file: 20953-66-6.mol

Synonyms:9-(4-CHLOROPHENYL)ACRIDINE;20953-66-6;9-(p-chlorophenyl)acridine;SCHEMBL601715;DTXSID50549358

Chemical Property of 9-(4-Chlorophenyl)acridine

Chemical Property:

• Vapor Pressure: 2.29E-07mmHg at 25°C
• XLogP3: 5.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 289.0658271
• Heavy Atom Count: 21
• Complexity: 328

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)C4=CC=C(C=C4)Cl

Technology Process of 9-(4-Chlorophenyl)acridine

There total 5 articles about 9-(4-Chlorophenyl)acridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-phenylaminobenzonitrile (17583-00-5) + 4-Chlorophenylboronic acid (1679-18-1) → 9-(4-chlorophenyl)acridine (20953-66-6)

Guidance literature:

With [2,2]bipyridinyl; methanesulfonic acid; palladium diacetate; In water; at 100 ℃; for 24h; Schlenk technique;

DOI:10.1021/acs.joc.0c01654

Reference yield: 81.0%

2-amino-4'-chlorobenzophenone (2894-51-1) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 9-(4-chlorophenyl)acridine (20953-66-6)

Guidance literature:

With 2-aminopyridine; palladium(II) trimethylacetate; oxygen; citric acid; In toluene; at 110 ℃; for 18h; under 760.051 Torr;

DOI:10.1002/adsc.201700715

Reference yield: 53.0%

9-Chloroacridine (1207-69-8) + 4-Chlorophenylboronic acid (1679-18-1) → 9-(4-chlorophenyl)acridine (20953-66-6)

Guidance literature:

With potassium phosphate; In toluene; at 100 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c7cc06958h

upstream raw materials:

diphenylamine

para-chlorobenzoic acid

9-bromoacridine

4-Chlorophenylboronic acid