5-methyl-1H-imidazo[4,5-b]pyridine

Base Information

• Chemical Name: 5-methyl-1H-imidazo[4,5-b]pyridine
• CAS No.: 27582-24-7
• Molecular Formula: C7H7N3
• Molecular Weight: 133.153
• Hs Code.: 2933990090
• European Community (EC) Number: 817-714-0
• DSSTox Substance ID: DTXSID10428059
• Wikidata: Q82240830
• Mol file: 27582-24-7.mol

Synonyms:5-methyl-1H-imidazo[4,5-b]pyridine;27582-24-7;5-METHYL-3H-IMIDAZO[4,5-B]PYRIDINE;1H-Imidazo[4,5-b]pyridine, 5-methyl-;3H-Imidazo[4,5-b]pyridine, 5-methyl-;5-Methylimidazo[4,5-b]pyridine;SCHEMBL14438024;DTXSID10428059;5-methyl-pyrido[2,3-d]imidazole;CBA58224;MFCD12546443;AKOS000320484;AKOS006239348;CCG-339814;DS-2636;CS-0059057;FT-0755271;C74433;EN300-190076;A876888;Z1925930546

Chemical Property of 5-methyl-1H-imidazo[4,5-b]pyridine

Chemical Property:

• PSA: 41.57000
• LogP: 1.26630
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 133.063997236
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

97% ^*data from raw suppliers

5-methyl-1H-imidazo[4,5-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=C(C=C1)NC=N2

Technology Process of 5-methyl-1H-imidazo[4,5-b]pyridine

There total 7 articles about 5-methyl-1H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-diamino-6-methyl-pyridine (33259-72-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 5-methylpyridol[2,3-d]imidazole (27582-24-7)

Guidance literature:

With copper diacetate;

Reference yield:

6-bromo-5-methylimidazo[4,5-b]pyridine (28279-41-6) → 5-methylpyridol[2,3-d]imidazole (27582-24-7)

Guidance literature:

With sodium hydroxide; palladium on activated charcoal; platinum; Hydrogenation;

Reference yield:

5-bromo-6-methyl-pyridin-2-ylamine (42753-71-9) → 5-methylpyridol[2,3-d]imidazole (27582-24-7)

Guidance literature:

Multi-step reaction with 4 steps

1: concentrated H₂SO₄; concentrated HNO₃

2: SnCl₂; aqueous HCl

4: palladium/charcoal; platinum; aq. NaOH solution / Hydrogenation

With hydrogenchloride; sodium hydroxide; palladium on activated charcoal; sulfuric acid; nitric acid; platinum; tin(ll) chloride;

upstream raw materials:

2,3-diamino-6-methyl-pyridine

formaldehyd

6-bromo-5-methylimidazo[4,5-b]pyridine

5-bromo-6-methyl-pyridin-2-ylamine