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| CAS No.: | 366789-02-8 |
|---|---|
| Name: | Rivaroxaban |
| Molecular Structure: | |
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| Formula: | C19H18ClN3O5S |
| Molecular Weight: | 435.888 |
| Synonyms: | 5-Chloro-N-[[(S)-3-(4-(3-oxomorpholin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]-thiophene-2-carboxamide;BAY 59-7939;Xarelto; |
| EINECS: | 685-132-2 |
| Density: | 1.46 g/cm3 |
| Melting Point: | 228-229°C |
| Boiling Point: | 732.609 °C at 760 mmHg |
| Flash Point: | 396.868 °C |
| PSA: | 116.42000 |
| LogP: | 3.04080 |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
5-chlorothiophene-2-carbonyl chloride
Rivaroxaban
| Conditions | Yield |
|---|---|
| With triethylamine In tetrahydrofuran at 20℃; for 3h; Product distribution / selectivity; | 100% |
| With triethylamine In tetrahydrofuran at 20℃; for 3h; Reagent/catalyst; Solvent; Time; Concentration; Temperature; | 100% |
| With sodium carbonate In water; acetone; toluene at 8 - 53℃; for 0.5h; | 98.7% |
5-chlorothiophene-2-carbonyl chloride
Rivaroxaban
| Conditions | Yield |
|---|---|
| With sodium carbonate In water; acetone at 10 - 50℃; for 0.5h; | 97.5% |
Rivaroxaban
| Conditions | Yield |
|---|---|
| With potassium carbonate In methanol at 20℃; for 2h; | 97% |
| Conditions | Yield |
|---|---|
| In ethanol at 36℃; for 7h; Solvent; | 96.4% |
5-Chlorothiophene-2-carboxylic acid
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Rivaroxaban
| Conditions | Yield |
|---|---|
| Stage #1: 5-Chlorothiophene-2-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 25℃; for 0.5h; Stage #2: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride In N,N-dimethyl-formamide at 34℃; for 4h; | 96.3% |
| With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 2.83333h; Reagent/catalyst; Cooling with ice; | 95.2% |
| With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 24h; pH=8 - 9; Large scale; | 94.7% |
5-chlorothiophene-2-carbonyl chloride
4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one methanesulfonic acid salt
Rivaroxaban
| Conditions | Yield |
|---|---|
| With potassium hydrogencarbonate In ethanol; water; butanone at 20 - 35℃; for 0.75h; Large scale; | 96% |
| With triethylamine In 1-methyl-pyrrolidin-2-one; toluene at 50 - 60℃; for 0.25h; | 81% |
5-chlorothiophene-2-carbonyl chloride
Rivaroxaban
| Conditions | Yield |
|---|---|
| Stage #1: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride With sodium carbonate In water; acetone at 8 - 12℃; Stage #2: 5-chlorothiophene-2-carbonyl chloride In water; acetone at 50 - 53℃; for 0.5h; Temperature; | 95.6% |
| With triethylamine In N,N-dimethyl-formamide at 30 - 40℃; for 5h; | 150.1 g |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
5-Chlorothiophene-2-carboxylic acid
Rivaroxaban
| Conditions | Yield |
|---|---|
| With 4-methyl-morpholine; hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 2.83333h; | 95.2% |
| With ortho-iodophenylboronic acid In dichloromethane at 30℃; for 48h; Reagent/catalyst; Time; Concentration; Temperature; Solvent; Dean-Stark; | 85% |
| With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; | 68.9% |
5-chloro-N-{(R)‐2‐hydroxy‐3‐[4‐(3-oxo-4-morpholinyl)phenylamino]-propyl}thiophene-2-carboxamide
1,1'-carbonyldiimidazole
Rivaroxaban
| Conditions | Yield |
|---|---|
| With dmap In acetone at 100℃; for 6h; | 95.1% |
| In 1-methyl-pyrrolidin-2-one; toluene at 20 - 115℃; for 1.33333h; | 91.5% |
| In 1-methyl-pyrrolidin-2-one; toluene at 20 - 110℃; for 3.5h; Inert atmosphere; | 90% |
5-chlorothiophene-2-carbonyl chloride
Rivaroxaban
| Conditions | Yield |
|---|---|
| With sodium carbonate In water; acetone at 10 - 50℃; for 0.5h; | 95% |
| With triethylamine In ethyl acetate at 10 - 20℃; for 1h; | 10 g |
