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1,3-diaminoguanidine hydrochloride
4-chlorobenzaldehyde
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 50℃; for 1h; pH=1.5; pH-value; Temperature; | 98.82% |
In ethanol for 16h; Reflux; |
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
2-(isocyanatomethyl)furan
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux; | 84% |
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
benzyl isothiocyanate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux; | 61% |
chloroformic acid ethyl ester
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux; | 42% |
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
isobutyl chloroformate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux; | 39% |
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
ethyl isocyanate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux; | 33% |
Hexyl isocyanate
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux; | 16% |
IUPAC Name:1,2-bis[(E)-(4-chlorophenyl)methylideneamino]guanidine hydrochloride
Synonyms: 1,2-Bis[(4-chlorophenyl)methylideneamino]guanidine hydrochloride ; Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride ; Robenidine hydrochloride ; Khimcoecid ; N, N'-Bis (p-chlorobenzylideneamino) quanidine
Molecular Structure of Robenidine (CAS NO. 25875-51-8) :
Molecular Formula of Robenidine (CAS NO. 25875-51-8) : C15H13Cl2N5.HCl
Molecular Weight of Robenidine (CAS NO. 25875-51-8) : 370.67
CAS NO: 25875-51-8
EINECS: 247-308-3
Robenidine (CAS NO. 25875-51-8) is a coccidiostat
Preparation Products: Robenidine hydrochloride
1. | orl-rat LD50:1350 mg/kg | VETNAL Veterinariya. 57 (9)(1981),53. | ||
2. | orl-mus LD50:1212 mg/kg | VETNAL Veterinariya. 53 (11)(1976),69. | ||
3. | orl-rbt LD50:1245 mg/kg | VETNAL Veterinariya. 57 (9)(1981),53. | ||
4. | orl-ckn LD50:500 mg/kg | VETNAL Veterinariya. 57 (9)(1981),53. | ||
5. | orl-dck LD50:1017 mg/kg | VETNAL Veterinariya. 57 (9)(1981),53. |
Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Cl− and NOx.
Robenidine with the cas number 25875-51-8, is also named 1,2-bis[(E)-(4-chlorophenyl)methylideneamino]guanidine by IUPAC. It is mainly used as coccidiostat. It is not used homemarket, because of the following cause:
Firstly, the Robenidine production cost is so high that consumer can use substitutes. Secondly, when it is used, it's drug-fast rate turned to be high rapidly. Besides, this chemical appeared bad smell.
You can still convert the following datas into molecular structure :
1. SMILES:Clc2ccc(/C=N/NC(=N\N=C\c1ccc(Cl)cc1)\N)cc2
2. InChI:InChI=1/C15H13Cl2N5/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12/h1-10H,(H3,18,21,22)/b19-9+,20-10+
Robenidine toxic data can be showed in the following sheet.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LD50 | oral | 500mg/kg (500mg/kg) | Veterinariya. Veterinary Science. Vol. 57(9), Pg. 53, 1981. | |
duck | LD50 | oral | 1017mg/kg (1017mg/kg) | Veterinariya. Veterinary Science. Vol. 57(9), Pg. 53, 1981. | |
mouse | LD50 | oral | 1212mg/kg (1212mg/kg) | Veterinariya. Veterinary Science. Vol. 53(11), Pg. 69, 1976. | |
rabbit | LD50 | oral | 1245mg/kg (1245mg/kg) | Veterinariya. Veterinary Science. Vol. 57(9), Pg. 53, 1981. | |
rat | LD50 | oral | 1350mg/kg (1350mg/kg) | Veterinariya. Veterinary Science. Vol. 57(9), Pg. 53, 1981. |