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Name |
Salicylic Acid |
EINECS | 200-712-3 |
CAS No. | 69-72-7 | Density | 1.376 g/cm3 |
PSA | 57.53000 | LogP | 1.09040 |
Solubility | 1.8 g/L (20 °C) in water | Melting Point |
158-161 °C(lit.) |
Formula | C7H6O3 | Boiling Point | 336.28 °C at 760 mmHg |
Molecular Weight | 138.123 | Flash Point | 144.486 °C |
Transport Information | N/A | Appearance | white crystalline powder |
Safety | 26-39-37/39-36 | Risk Codes | 22-41-36/37/38 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
SAX;Salicylic Acid(Medical);Salicylic Acid (technical grade);Salicylic Acid(natural);Dr. Scholls Corn Removers;o-Hydroxybenzoic acid;Freezone;Stri-Dex;Compound W;K 537;54-21-7;Phenol-2-carboxylic acid;2-Hydroxybenzenecarboxylic acid;Keralyt;2-Hydroxybenzoic acid;o-Carboxyphenol;Salicylic acid (TN);Dr. Scholls Callus Removers;Salicylic acid (6CI,8CI);Verrugon;Ionil;Kyselina 2-hydroxybenzoova [Czech];CPD-110;Clear away Wart Remover;Saligel;salicylate;2-Carboxyphenol;Benzoic acid, 2-hydroxy- (9CI);Ionil Plus;Duoplant;benzoic acid, 2-hydroxy-; |
Article Data | 719 |
Salicylic acid is a monohydroxybenzoic acid, a type of phenolic acid and a beta hydroxy acid. With the CAS NO. 69-72-7, This colorless crystalline organic acid is widely used in organic synthesis and functions as a plant hormone. It is derived from the metabolism of salicin.
Physical properties about Salicylic acid are: (1)ACD/LogP: 2.011; (2)ACD/LogD (pH 5.5): -0.92; (3)ACD/LogD (pH 7.4): -1.14; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 3; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 2; (11)Index of Refraction: 1.616; (12)Molar Refractivity: 35.064 cm3; (13)Molar Volume: 100.393 cm3; (14)Polarizability: 13.901 10-24cm3; (15)Surface Tension: 64.4169998168945 dyne/cm; (16)Density: 1.376 g/cm3; (17)Flash Point: 144.486 °C ; (18)Enthalpy of Vaporization: 61.157 kJ/mol; (19)Boiling Point: 336.28 °C at 760 mmHg
Preparation of Salicylic Acid: Salicylic acid is biosynthesized from the amino acid phenylalanine. In Arabidopsis thaliana it can also be synthesized via a phenylalanine-independent pathway.
Salicylic acid is commercially prepared by treating sodium phenolate (the sodium salt of phenol) with carbon dioxide at high pressure (100 atm) and high temperature (390K) -a method known as the Kolbe-Schmitt reaction. Acidification of the product with sulfuric acid gives salicylic acid:
It can also be prepared by the hydrolysis of aspirin (acetylsalicylic acid) or methyl salicylate (oil of wintergreen) with a strong acid or base.
Uses of Salicylic Acid: Salicylic Acid is mainly applicated for the pharmaceutical industry especially in the manufacture of antipyretic, analgesic, anti-inflammatory, and diuretic drugs.It's also used in dyes industrial for azo direct dye and acidic mordant dyeing, and also for spices, etc.
When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2.Wear eye/face protection;
3.Wear suitable gloves and eye/face protection;
4. Wear suitable protective clothing;
You can still convert the following datas into molecular structure:
(1)InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10);
(2) InChIKey=YGSDEFSMJLZEOE-UHFFFAOYSA-N;
(3)Smilesc1(c(cccc1)O)C(=O)O;
The toxiciy data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | oral | 400mg/kg (400mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959. | |
mammal (species unspecified) | LC50 | inhalation | > 300mg/m3 (300mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992. | |
man | TDLo | skin | 57mg/kg (57mg/kg) | SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR | JAMA, Journal of the American Medical Association. Vol. 244, Pg. 660, 1980. |
mouse | LD50 | intraperitoneal | 300mg/kg (300mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gendai no Rinsho. Vol. 3, Pg. 675, 1969. |
mouse | LD50 | intravenous | 184mg/kg (184mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Yakugaku Zasshi. Journal of Pharmacy. Vol. 91, Pg. 550, 1971. |
mouse | LD50 | oral | 480mg/kg (480mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959. | |
mouse | LD60 | subcutaneous | 520mg/kg (520mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS CARDIAC: CHANGE IN RATE | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 38, Pg. 9, 1930. |
rabbit | LD50 | oral | 1300mg/kg (1300mg/kg) | Drugs in Japan Vol. 6, Pg. 291, 1982. | |
rabbit | LD50 | skin | > 10gm/kg (10000mg/kg) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971, | |
rabbit | LDLo | subcutaneous | 6gm/kg (6000mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935. | |
rat | LC50 | inhalation | > 900mg/m3/1H (900mg/m3) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971, | |
rat | LD50 | intraperitoneal | 157mg/kg (157mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992. |
rat | LD50 | oral | 891mg/kg (891mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971, |
rat | LD50 | skin | > 2gm/kg (2000mg/kg) | LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 15(Suppl, |
women | TDLo | skin | 111mg/kg/10D- (111mg/kg) | Postgraduate Medical Journal. Vol. 70, Pg. 146, 1994. | |
women | TDLo | skin | 111mg/kg/10D- (111mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR | Postgraduate Medical Journal. Vol. 70, Pg. 146, 1994. |