CAS No.303-38-8,2,3-Dihydroxybenzoic acid Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	303-38-8
Name:	2,3-Dihydroxybenzoic acid
Article Data:	65

Formula:	C₇H₆O₄
Molecular Weight:	154.122
Synonyms:	o-Pyrocatechuicacid (6CI,8CI);1,2-Dihydroxybenzene-3-carboxylic acid;3-Hydroxysalicylic acid;DHBA;NSC 27435;Pyrocatechuic acid;
EINECS:	206-139-5
Density:	1.559 g/cm³
Melting Point:	204-206 °C(lit.)
Boiling Point:	362.5 °C at 760 mmHg
Flash Point:	187.2 °C
Solubility:	Soluble in water, methanol and dimethyl sulfoxide.
Appearance:	pale brownish to red brownish crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36-37/39
PSA:	77.76000
LogP:	0.79600

Synthetic route

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 303-38-8
2,3-Dihydroxybenzoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetonitrile at 45℃; for 12h; chemoselective reaction;	82%

: 3943-73-5
2,3-dihydroxybenzoicacid ethylester

: 303-38-8
2,3-Dihydroxybenzoic acid

Conditions

Conditions	Yield
With lithium hydroxide In ethanol; water at 25℃; for 2h;	71%

: 65-85-0
benzoic acid

A: 303-38-8
2,3-Dihydroxybenzoic acid

B: 490-79-9
2,5-dihydroxybenzoic acid.

C: 99-06-9
3-Carboxyphenol

D: 69-72-7
salicylic acid

E: 99-96-7
4-hydroxy-benzoic acid

Conditions

Conditions	Yield
With oxygen; iron(II) sulfate In water at 40℃; for 3h; Product distribution; pH 6.8 buffer;	A 9% B 5% C 14% D 4% E 9%

...Expand

: 65-85-0
benzoic acid

A: 303-38-8
2,3-Dihydroxybenzoic acid

B: 490-79-9
2,5-dihydroxybenzoic acid.

C: 99-06-9
3-Carboxyphenol

D: 99-96-7
4-hydroxy-benzoic acid

Conditions

Conditions	Yield
With oxygen; iron(II) sulfate In water at 40℃; for 3h; Further byproducts given;	A 9% B 5% C 14% D 9%

...Expand

: 610-04-8
3-formylsalicylic acid

: 303-38-8
2,3-Dihydroxybenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide

: 520-79-6
2-hydroxy-3-iodobenzoic acid

: 303-38-8
2,3-Dihydroxybenzoic acid

Conditions

Conditions	Yield
With potassium carbonate beim Schmelzen;

: 877-22-5
3-methoxysalicylic acid

: 303-38-8
2,3-Dihydroxybenzoic acid

Conditions

Conditions	Yield
With aluminium trichloride; chlorobenzene
With hydrogenchloride at 140℃; im Rohr;
With aluminium trichloride at 150℃;
With hydrogen bromide at 110 - 120℃;

: 1521-38-6
2,3-dimethoxybenzoic acid

: 303-38-8
2,3-Dihydroxybenzoic acid

Conditions

Conditions	Yield
With hydrogen iodide at 100℃;
Multi-step reaction with 5 steps 1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2 h / 30 - 35 °C 2: ammonium hydroxide / dichloromethane; water / 0.5 h / -5 - 35 °C 3: trichlorophosphate / toluene / 30 - 85 °C 4: triethylamine; aluminum (III) chloride / toluene / 9.5 h / 30 - 75 °C 5: water; hydrogenchloride / toluene / 0.5 h / 15 - 35 °C View Scheme

: 62672-58-6
2-iodo-3-hydroxybenzaldehyde

: furan-2,3,5(4H)-trione pyridine (1:1)

: 303-38-8
2,3-Dihydroxybenzoic acid

Conditions

Conditions	Yield
at 100℃;

: 23806-63-5
3-(benzyloxy)-2-hydroxybenzoic acid

: 303-38-8
2,3-Dihydroxybenzoic acid

Conditions

Conditions	Yield
With hydrogen bromide at 100 - 110℃;

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Chemistry

Molecular Formula: C₇H₆O₄

Formula Weight: 154.12
mp : 204-206^°C(lit.)
bp of 2,3-Dihydroxybenzoic Acid (303-38-8): 95-96/0.5mm
Flash Point: 187.2 ^°C
density of 2,3-Dihydroxybenzoic Acid (303-38-8): 1,542 g/cm³
Vapour Pressure: 6.85E-06 mmHg at 25^°C
storage temp. : 2-8^°C
Index of Refraction: 1.67
SOLUBILITY IN WATER: Soluble
Appearence of 2,3-Dihydroxybenzoic Acid (303-38-8): Pale Brownish to Red Brownish Crystalline Powder

Uses

2,3-Dihydroxybenzoic Acid (303-38-8) is used as intermediate for pharmaceuticals (especially for antipyetic anlgesic, antirheumatism) and other organic synthesis.
In industrial field, 2,3-Dihydroxybenzoic Acid (303-38-8) is used as intermediate for the production of other organic chemicals, resins, polyesters, plasticizers, dyestuffs, preservatives, and rubber chemicals.

Toxicity Data With Reference

Oral: LD₅₀: >3 gm/kg (rbt)
on the eye: Irritating effect.
on the skin: Irritant to skin and mucous membranes.

Safety Profile

Safety: WARNING: Irritates lungs, eyes, skin
Hazard Codes : Xi (Irritant)
Risk Statements : 36/37/38 (Irritating to eyes, respiratory system and skin)
Safety Statements : 26-36-37/39 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing; Wear suitable gloves and eye/face protection)
WGK Germany : 2
RTECS : DG8576490
Hazard Note : Irritant

Standards and Recommendations

ASSAY: 99.0% m in
LOSS ON DRYING: 0.5% max
RESIDUE ON IGNITION: 0.1% max

Specification

Storage of 2,3-Dihydroxybenzoic Acid (303-38-8): Store in cool, dry conditions in well sealed containers. Store away from oxidizing agents. Store away from strong bases. Keep container tightly sealed.