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Basic Information
| CAS No.: | 303-38-8 |
|---|---|
| Name: | 2,3-Dihydroxybenzoic acid |
| Molecular Structure: | |
|
|
|
| Formula: | C7H6O4 |
| Molecular Weight: | 154.122 |
| Synonyms: | o-Pyrocatechuicacid (6CI,8CI);1,2-Dihydroxybenzene-3-carboxylic acid;3-Hydroxysalicylic acid;DHBA;NSC 27435;Pyrocatechuic acid; |
| EINECS: | 206-139-5 |
| Density: | 1.559 g/cm3 |
| Melting Point: | 204-206 °C(lit.) |
| Boiling Point: | 362.5 °C at 760 mmHg |
| Flash Point: | 187.2 °C |
| Solubility: | Soluble in water, methanol and dimethyl sulfoxide. |
| Appearance: | pale brownish to red brownish crystalline powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36-37/39 |
| PSA: | 77.76000 |
| LogP: | 0.79600 |
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Synthetic route
- 24677-78-9
2,3-dihydroxybenzaldehyde
- 303-38-8
2,3-Dihydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| With dihydrogen peroxide In water; acetonitrile at 45℃; for 12h; chemoselective reaction; | 82% |
Conditions
| Conditions | Yield |
|---|---|
| With lithium hydroxide In ethanol; water at 25℃; for 2h; | 71% |
- 65-85-0
benzoic acid
A
- 303-38-8
2,3-Dihydroxybenzoic acid
B
- 490-79-9
2,5-dihydroxybenzoic acid.
C
- 99-06-9
3-Carboxyphenol
D
- 69-72-7
salicylic acid
E
- 99-96-7
4-hydroxy-benzoic acid
Conditions
| Conditions | Yield |
|---|---|
| With oxygen; iron(II) sulfate In water at 40℃; for 3h; Product distribution; pH 6.8 buffer; | A 9% B 5% C 14% D 4% E 9% |
...Expand
- 65-85-0
benzoic acid
A
- 303-38-8
2,3-Dihydroxybenzoic acid
B
- 490-79-9
2,5-dihydroxybenzoic acid.
C
- 99-06-9
3-Carboxyphenol
D
- 99-96-7
4-hydroxy-benzoic acid
Conditions
| Conditions | Yield |
|---|---|
| With oxygen; iron(II) sulfate In water at 40℃; for 3h; Further byproducts given; | A 9% B 5% C 14% D 9% |
...Expand
Conditions
| Conditions | Yield |
|---|---|
| With sodium hydroxide; dihydrogen peroxide |
Conditions
| Conditions | Yield |
|---|---|
| With potassium carbonate beim Schmelzen; |
Conditions
| Conditions | Yield |
|---|---|
| With aluminium trichloride; chlorobenzene | |
| With hydrogenchloride at 140℃; im Rohr; | |
| With aluminium trichloride at 150℃; | |
| With hydrogen bromide at 110 - 120℃; |
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen iodide at 100℃; | |
| Multi-step reaction with 5 steps 1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2 h / 30 - 35 °C 2: ammonium hydroxide / dichloromethane; water / 0.5 h / -5 - 35 °C 3: trichlorophosphate / toluene / 30 - 85 °C 4: triethylamine; aluminum (III) chloride / toluene / 9.5 h / 30 - 75 °C 5: water; hydrogenchloride / toluene / 0.5 h / 15 - 35 °C View Scheme |
- 62672-58-6
2-iodo-3-hydroxybenzaldehyde
- 303-38-8
2,3-Dihydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| at 100℃; |
- 23806-63-5
3-(benzyloxy)-2-hydroxybenzoic acid
- 303-38-8
2,3-Dihydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen bromide at 100 - 110℃; |
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2,3-Dihydroxybenzoic acid
Chemistry
Molecular Formula: C7H6O4 
Formula Weight: 154.12
mp : 204-206 °C(lit.)
bp of 2,3-Dihydroxybenzoic Acid (303-38-8): 95-96/0.5mm
Flash Point: 187.2 °C
density of 2,3-Dihydroxybenzoic Acid (303-38-8): 1,542 g/cm3
Vapour Pressure: 6.85E-06 mmHg at 25°C
storage temp. : 2-8°C
Index of Refraction: 1.67
SOLUBILITY IN WATER: Soluble
Appearence of 2,3-Dihydroxybenzoic Acid (303-38-8): Pale Brownish to Red Brownish Crystalline Powder
Formula Weight: 154.12
mp : 204-206 °C(lit.)
bp of 2,3-Dihydroxybenzoic Acid (303-38-8): 95-96/0.5mm
Flash Point: 187.2 °C
density of 2,3-Dihydroxybenzoic Acid (303-38-8): 1,542 g/cm3
Vapour Pressure: 6.85E-06 mmHg at 25°C
storage temp. : 2-8°C
Index of Refraction: 1.67
SOLUBILITY IN WATER: Soluble
Appearence of 2,3-Dihydroxybenzoic Acid (303-38-8): Pale Brownish to Red Brownish Crystalline Powder
Uses
2,3-Dihydroxybenzoic Acid (303-38-8) is used as intermediate for pharmaceuticals (especially for antipyetic anlgesic, antirheumatism) and other organic synthesis.
In industrial field, 2,3-Dihydroxybenzoic Acid (303-38-8) is used as intermediate for the production of other organic chemicals, resins, polyesters, plasticizers, dyestuffs, preservatives, and rubber chemicals.
In industrial field, 2,3-Dihydroxybenzoic Acid (303-38-8) is used as intermediate for the production of other organic chemicals, resins, polyesters, plasticizers, dyestuffs, preservatives, and rubber chemicals.
Toxicity Data With Reference
Oral: LD50: >3 gm/kg (rbt)
on the eye: Irritating effect.
on the skin: Irritant to skin and mucous membranes.
on the eye: Irritating effect.
on the skin: Irritant to skin and mucous membranes.
Safety Profile
Safety: WARNING: Irritates lungs, eyes, skin
Hazard Codes : Xi (Irritant)
Risk Statements : 36/37/38 (Irritating to eyes, respiratory system and skin)
Safety Statements : 26-36-37/39 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing; Wear suitable gloves and eye/face protection)
WGK Germany : 2
RTECS : DG8576490
Hazard Note : Irritant
Hazard Codes : Xi (Irritant)
Risk Statements : 36/37/38 (Irritating to eyes, respiratory system and skin)
Safety Statements : 26-36-37/39 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing; Wear suitable gloves and eye/face protection)
WGK Germany : 2
RTECS : DG8576490
Hazard Note : Irritant
Standards and Recommendations
ASSAY: 99.0% m in
LOSS ON DRYING: 0.5% max
RESIDUE ON IGNITION: 0.1% max
LOSS ON DRYING: 0.5% max
RESIDUE ON IGNITION: 0.1% max
Specification
Storage of 2,3-Dihydroxybenzoic Acid (303-38-8): Store in cool, dry conditions in well sealed containers. Store away from oxidizing agents. Store away from strong bases. Keep container tightly sealed.