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Cas Database |
| Name |
Tenofovir |
EINECS | 604-571-2 |
| CAS No. | 147127-20-6 | Density | 1.79 g/cm3 |
| PSA | 146.19000 | LogP | 0.53000 |
| Solubility | Water solubility: 13.4 mg/mL (25 °C) | Melting Point |
276-280 °C |
| Formula | C9H14N5O4P | Boiling Point | 616.1 °C at 760 mmHg |
| Molecular Weight | 287.215 | Flash Point | 326.4 °C |
| Transport Information | N/A | Appearance | white crystalline solid |
| Safety | Risk Codes | R34 | |
| Molecular Structure |
|
Hazard Symbols |
 C
|
| Synonyms |
(R)-9-[2-(phosphonomethoxy)propyl]adenine;Tenofovir disoproxil fumarate and intermediates;Phosphonic acid, (((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)-;[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid;Phosphonic acid, ((2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)-, (R)-; |
Article Data | 66 |
Tenofovir Synthetic route
- 180587-75-1
(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
- 147127-20-6
tenofovir
| Conditions | Yield |
|---|---|
| With hydrogenchloride In N,N-dimethyl-formamide at 130℃; under 7500.75 Torr; for 0.0416667h; Solvent; Pressure; Temperature; Inert atmosphere; | 95% |
| With trimethylsilyl bromide In acetonitrile at 65℃; for 1h; | 90% |
| With sulfuric acid at 90 - 110℃; | 83.8% |
- 147127-20-6
tenofovir
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water for 5h; Reflux; | 91.8% |
- 160616-04-6
bis(2-propyl) (R)-9-(2-phosphonomethoxypropyl)adenine
- 147127-20-6
tenofovir
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 130 - 140℃; Microwave irradiation; Sealed tube; | 91% |
| With hydrogenchloride In water at 140℃; for 0.5h; Temperature; Time; Reagent/catalyst; Microwave irradiation; | 90% |
| With hydrogenchloride In water at 140℃; for 0.5h; Temperature; Reagent/catalyst; Microwave irradiation; | 90% |
- 147127-20-6
tenofovir
| Conditions | Yield |
|---|---|
| With potassium hydroxide In water for 5h; Reflux; | 88.7% |
- 147127-20-6
tenofovir
| Conditions | Yield |
|---|---|
| In ethyl acetate at 0 - 10℃; for 2h; Cooling with ice; | 85.4% |
- 180587-75-1
(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
B
- 147127-20-6
tenofovir
| Conditions | Yield |
|---|---|
| With hydrogen bromide at 100℃; for 15h; | A n/a B 84.6% |
- 147127-20-6
tenofovir
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water for 5h; Reflux; | 82.5% |
- 161760-09-4
{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid
- 14047-28-0
(R)-9-(2-hydroxypropyl)adenine
B
- 147127-20-6
tenofovir
| Conditions | Yield |
|---|---|
| In 1-methyl-pyrrolidin-2-one at 0 - 20℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Molecular sieve; | A 12% B 82% |
- 147127-20-6
tenofovir
| Conditions | Yield |
|---|---|
| Stage #1: C12H18N5O5P With sodium hydroxide In water for 2h; Cooling with ice; Stage #2: With hydrogenchloride; sodium hydroxide In water at 5℃; for 10h; pH=2.5; | 81.3% |
- 147127-20-6
tenofovir
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 90 - 110℃; | 78.1% |
Tenofovir Chemical Properties
Empirical Formula: C9H14N5O4P
Molecular Weight: 287.2123 g/mol
Index of Refraction: 1.739
Density: 1.79 g/cm3
Flash Point: 326.4 °C
Melting point: 276-280 °C
Enthalpy of Vaporization: 96.07 kJ/mol
Boiling Point: 616.1 °C at 760 mmHg
Vapour Pressure: 4.92E-16 mmHg at 25 °C
Water solubility: 13.4 mg/mL (25 °C)
Appearance: White crystalline solid
Structure of Tenofovir (CAS NO.147127-20-6):
IUPAC Name: [(2R)-1-(6-Aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
Product Category of Tenofovir (CAS NO.147127-20-6): Purine;Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates & Fine Chemicals
Tenofovir Uses
Tenofovir (CAS NO.147127-20-6) is acyclic phosphonate nucleotide analogue, and has been used as an anti-HIV agent.
Tenofovir Specification
Tenofovir , its cas register number is 147127-20-6. It also can be called 1-(6-Aminopurin-9-yl)propan-2-yloxymethylphosphonic acid ; and PMPA prodrug .
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