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Tetracaine
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  • Name Tetracaine
  • EINECS202-316-6
  • CAS No. 94-24-6
  • Density1.044 g/cm3
  • PSA41.57000
  • LogP2.69000
  • Solubility156mg/L(temperature not stated)
  • Melting Point41.0 to 45.0 °C
  • FormulaC15H24N2O2
  • Boiling Point389.4 °C at 760 mmHg
  • Molecular Weight264.368
  • Flash Point189.3 °C
  • Transport InformationUN 2811
  • AppearanceWhite crystalline powder
  • Safety22-36/37
  • Risk Codes22-40-42/43-43
  • Molecular Structure
    Molecular Structure of 94-24-6 (Tetracaine)
  • Hazard SymbolsHarmfulXn, IrritantXi
  • SynonymsHarmfulXn, IrritantXi
  • Article Data10

Tetracaine Synthetic route

109-65-9

1-bromo-butane

10012-47-2

Dimethylprocaine

94-24-6

amethocaine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 5h;82.8%
With butan-1-ol
108-01-0

2-(N,N-dimethylamino)ethanol

99-77-4

ethyl 4-nitrobenzoate

123-72-8

butyraldehyde

94-24-6

amethocaine

Conditions
ConditionsYield
With hydrogen; palladium-containing anion exchanger AV-17-8 In ethanol at 45℃; under 760 Torr; Kinetics; Further Variations:; Catalysts; concentrations;94%
With hydrogen; palladium-containing anion exchanger AV-17-8 In ethanol at 45℃; under 760 Torr;94%

2-(dimethylamino)ethyl 4-bromobenzoate

109-73-9

N-butylamine

94-24-6

amethocaine

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; nickel(II) bromide dimethoxyethane; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate In dimethyl sulfoxide at 80℃; for 0.166667h; Flow reactor; Sealed tube; Schlenk technique; Inert atmosphere; Irradiation;85%
108-01-0

2-(N,N-dimethylamino)ethanol

4740-24-3

4-(N-butylamino)benzoic acid

94-24-6

amethocaine

Conditions
ConditionsYield
With hydrogenchloride; toluene
With sodium hydride; 1,1'-carbonyldiimidazole In 1,2-dimethoxyethane at 60℃;
38152-22-6

4-nitrobenzoic acid 2-(dimethylamino)ethyl ester

94-24-6

amethocaine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: iron; acetic acid / 8 h / 30 °C
2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C
View Scheme
122-04-3

4-nitro-benzoyl chloride

94-24-6

amethocaine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane / 2 h / 0 °C
2: iron; acetic acid / 8 h / 30 °C
3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C
View Scheme
94-09-7

p-aminoethylbenzoate

94-24-6

amethocaine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: zinc; acetic acid; benzene
2: aq.-ethanolic KOH-solution
3: toluene; hydrogen chloride
View Scheme
Multi-step reaction with 2 steps
1: zinc; acetic acid; benzene
2: sodium ethylate
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate; copper / 160 °C
2: aq.-ethanolic KOH-solution
3: toluene; hydrogen chloride
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate; copper / 160 °C
2: sodium ethylate
View Scheme
108-01-0

2-(N,N-dimethylamino)ethanol

94-32-6

ethyl 4-(N-butylamino)benzoate

94-24-6

amethocaine

Conditions
ConditionsYield
With sodium ethanolate
108-01-0

2-(N,N-dimethylamino)ethanol

4-butylamino-benzoyl chloride ; hydrochloride

94-24-6

amethocaine

Conditions
ConditionsYield
With diethyl ether
With benzene
4740-24-3

4-(N-butylamino)benzoic acid

94-24-6

amethocaine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen chloride
2: sodium ethylate
View Scheme
Multi-step reaction with 2 steps
1: hydrogen chloride
2: benzene
View Scheme

Tetracaine Chemical Properties

Product Name: Tetracaine (CAS NO.94-24-6)

Molecular Formula: C15H24N2O2     
Molecular Weight: 264.36g/mol
Density:1.044 g/cm3  
Boiling point:389.4 °C at 760 mmHg 
Flash point:189.3 °C    
Index of Refraction:1.537 
Molar Refractivity:79.15 cm3 
Molar Volume:253 cm3
Polarizability:31.37 10-24cm3
Surface Tension:39.7 dyne/cm
Enthalpy of Vaporization:63.87 kJ/mol  
Vapour Pressure:2.87E-06 mmHg at 25°C 
IUPAC Name: 2-dimethylaminoethyl 4-(butylamino)benzoate
Product Categories: API

Tetracaine Uses

 It's used as narcotic drugs.

Tetracaine Toxicity Data With Reference

1.    

dnd-esc 30 µmol/L

     MUREAV    Mutation Research. 89 (1981),95.
2.    

dns-hmn:hla 1 µmol/L

     BCPCA6    Biochemical Pharmacology. 14 (1965),205.
3.    

par-man LDLo:1 mg/kg:CNS,PUL

     SAVEAB    Sammlung von Vergiftungsfaellen. 10 (1939),50.
4.    

ivn-rat LD50:6 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 8 (1958),539.
5.    

ipr-mus LD50:20 mg/kg

     RPTOAN    Russian Pharmacology and Toxicology. Translation of FATOAO. 35 (3)(1972),114.
6.    

scu-mus LD50:25 mg/kg

     PHTXA6    Pharmacology and Toxicology. Translation of FATOAO. 20 (1957),521.
7.    

ivn-mus LD50:6 mg/kg

     EJMCA5    European Journal of Medicinal Chemistry. Chimie Therapeutique. 10 (1975),291.
8.    

scu-rbt LDLo:20 mg/kg

     AEPPAE    Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 160 (1931),53.
9.    

ivn-rbt LDLo:6 mg/kg

     AEPPAE    Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 160 (1931),53.
10.    

par-rbt LD50:33,500 µg/kg

     ARZNAD    Arzneimittel-

Tetracaine Safety Profile

A human poison by parenteral route with systemic effects including: muscle contractions, coma, and cyanosis. A poison experimentally by intravenous, parenteral, intratracheal, intraperitoneal, and subcutaneous routes. Human mutation data reported. A local anesthetic. See also ESTERS. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:Xn,Xi
Xi:Irritant
Xn:Harmful
Risk Statements
R22:Harmful if swallowed.
R40:Limited evidence of a carcinogenic effect.
R42/43:May cause sensitization by inhalation and skin contact .
R43:May cause sensitization by skin contact.
Safety Statements
S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves .
RIDADR:UN 2811
RTECS:DG4725000  

Tetracaine Specification

 Tetracaine , its CAS NO. is 94-24-6, the synonyms are 2-(Dimethylamino)ethyl p-(butylamino)benzoate ; 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove ; 2-Dimethylaminoethylesterkyselinyp-butylaminobenzoove ; 2-Dimethylaminoethylp-butylaminobenzoate ; 4-(Butylamino)-benzoicaci2-(dimethylamino)ethylester ; Amethocaine ; Anetain ; 2-(Dimethylamino)ethyl 4-(butylamino)benzoate . 

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