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| CAS No.: | 94-24-6 |
|---|---|
| Name: | Tetracaine |
| Molecular Structure: | |
|
|
|
| Formula: | C15H24N2O2 |
| Molecular Weight: | 264.368 |
| Synonyms: | Benzoicacid, p-(butylamino)-, 2-(dimethylamino)ethyl ester (8CI);2-Dimethylaminoethylp-butylaminobenzoate;Amethocaine;Ametop;Anetain;Butylocaine;Contralgin;Fissucain;Intercain;Laudocaine;Medicaine;Medihaler-Tetracaine;Meethobalm;Metraspray;Mucaesthin;Pontocaine;Rexocaine;Uromucaesthin;b-Dimethylaminoethylp-N-butylaminobenzoate;b-Dimethylaminoethyl p-butylaminobenzoate; |
| EINECS: | 202-316-6 |
| Density: | 1.044 g/cm3 |
| Melting Point: | 41.0 to 45.0 °C |
| Boiling Point: | 389.4 °C at 760 mmHg |
| Flash Point: | 189.3 °C |
| Solubility: | 156mg/L(temperature not stated) |
| Appearance: | White crystalline powder |
| Hazard Symbols: |
 Xn,  Xi
|
| Risk Codes: | 22-40-42/43-43 |
| Safety: | 22-36/37 |
| Transport Information: | UN 2811 |
| PSA: | 41.57000 |
| LogP: | 2.69000 |
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 5h; | 82.8% |
| With butan-1-ol |
2-(N,N-dimethylamino)ethanol
ethyl 4-nitrobenzoate
butyraldehyde
amethocaine
| Conditions | Yield |
|---|---|
| With hydrogen; palladium-containing anion exchanger AV-17-8 In ethanol at 45℃; under 760 Torr; Kinetics; Further Variations:; Catalysts; concentrations; | 94% |
| With hydrogen; palladium-containing anion exchanger AV-17-8 In ethanol at 45℃; under 760 Torr; | 94% |
| Conditions | Yield |
|---|---|
| With 1,4-diaza-bicyclo[2.2.2]octane; nickel(II) bromide dimethoxyethane; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate In dimethyl sulfoxide at 80℃; for 0.166667h; Flow reactor; Sealed tube; Schlenk technique; Inert atmosphere; Irradiation; | 85% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; toluene | |
| With sodium hydride; 1,1'-carbonyldiimidazole In 1,2-dimethoxyethane at 60℃; |
4-nitrobenzoic acid 2-(dimethylamino)ethyl ester
amethocaine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: iron; acetic acid / 8 h / 30 °C 2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: dichloromethane / 2 h / 0 °C 2: iron; acetic acid / 8 h / 30 °C 3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: zinc; acetic acid; benzene 2: aq.-ethanolic KOH-solution 3: toluene; hydrogen chloride View Scheme | |
| Multi-step reaction with 2 steps 1: zinc; acetic acid; benzene 2: sodium ethylate View Scheme | |
| Multi-step reaction with 3 steps 1: potassium carbonate; copper / 160 °C 2: aq.-ethanolic KOH-solution 3: toluene; hydrogen chloride View Scheme | |
| Multi-step reaction with 2 steps 1: potassium carbonate; copper / 160 °C 2: sodium ethylate View Scheme |
| Conditions | Yield |
|---|---|
| With sodium ethanolate |
| Conditions | Yield |
|---|---|
| With diethyl ether | |
| With benzene |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: hydrogen chloride 2: sodium ethylate View Scheme | |
| Multi-step reaction with 2 steps 1: hydrogen chloride 2: benzene View Scheme |
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Product Name: Tetracaine (CAS NO.94-24-6)
Molecular Formula: C15H24N2O2
Molecular Weight: 264.36g/mol
Density:1.044 g/cm3
Boiling point:389.4 °C at 760 mmHg
Flash point:189.3 °C
Index of Refraction:1.537
Molar Refractivity:79.15 cm3
Molar Volume:253 cm3
Polarizability:31.37 10-24cm3
Surface Tension:39.7 dyne/cm
Enthalpy of Vaporization:63.87 kJ/mol
Vapour Pressure:2.87E-06 mmHg at 25°C
IUPAC Name: 2-dimethylaminoethyl 4-(butylamino)benzoate
Product Categories: API
It's used as narcotic drugs.
| 1. | dnd-esc 30 µmol/L | MUREAV Mutation Research. 89 (1981),95. | ||
| 2. | dns-hmn:hla 1 µmol/L | BCPCA6 Biochemical Pharmacology. 14 (1965),205. | ||
| 3. | par-man LDLo:1 mg/kg:CNS,PUL | SAVEAB Sammlung von Vergiftungsfaellen. 10 (1939),50. | ||
| 4. | ivn-rat LD50:6 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 8 (1958),539. | ||
| 5. | ipr-mus LD50:20 mg/kg | RPTOAN Russian Pharmacology and Toxicology. Translation of FATOAO. 35 (3)(1972),114. | ||
| 6. | scu-mus LD50:25 mg/kg | PHTXA6 Pharmacology and Toxicology. Translation of FATOAO. 20 (1957),521. | ||
| 7. | ivn-mus LD50:6 mg/kg | EJMCA5 European Journal of Medicinal Chemistry. Chimie Therapeutique. 10 (1975),291. | ||
| 8. | scu-rbt LDLo:20 mg/kg | AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 160 (1931),53. | ||
| 9. | ivn-rbt LDLo:6 mg/kg | AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 160 (1931),53. | ||
| 10. | par-rbt LD50:33,500 µg/kg | ARZNAD Arzneimittel- |
A human poison by parenteral route with systemic effects including: muscle contractions, coma, and cyanosis. A poison experimentally by intravenous, parenteral, intratracheal, intraperitoneal, and subcutaneous routes. Human mutation data reported. A local anesthetic. See also ESTERS. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:Xn,Xi
Xi:Irritant
Xn:Harmful
Risk Statements
R22:Harmful if swallowed.
R40:Limited evidence of a carcinogenic effect.
R42/43:May cause sensitization by inhalation and skin contact .
R43:May cause sensitization by skin contact.
Safety Statements
S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves .
RIDADR:UN 2811
RTECS:DG4725000
Tetracaine , its CAS NO. is 94-24-6, the synonyms are 2-(Dimethylamino)ethyl p-(butylamino)benzoate ; 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove ; 2-Dimethylaminoethylesterkyselinyp-butylaminobenzoove ; 2-Dimethylaminoethylp-butylaminobenzoate ; 4-(Butylamino)-benzoicaci2-(dimethylamino)ethylester ; Amethocaine ; Anetain ; 2-(Dimethylamino)ethyl 4-(butylamino)benzoate .
