Biaryl

Synthesis Inhibitors Selectivity Lead compound Chemical reactions IC50 Pharmacophore binding affinity Intramolecular Aromatic ring X-ray crystallography Docking Studies Structure-Activity Relationship (SAR) Enzyme Kinetics Biological Activity Bioavailability Metabolic Stability In vitro assay Approach Nonracemic Nonpeptidic Vancomycin Cysteine protease Protease Allosteric site Cyclic AMP Ni(0)-mediated Ki (Inhibition constant)