Protease

Crystal structure Inhibitors Enantioselective Selectivity Nucleophile Molecular docking Lead compound Synthetic route Amines IC50 Pharmacophore binding affinity X-ray crystallography Lead Optimization Docking Studies Computational Modeling Structure-Activity Relationship (SAR) Enzyme Kinetics Chirality Kinetic Resolution Substrate Specificity High-Throughput Screening (HTS) Biological Activity Bioavailability Metabolic Stability In vitro assay Renin inhibitors Electron-deficient Enzyme assay Model compounds Active site Reactive Intermediates In vivo study Electron-withdrawing group Nonpeptidic Protease inhibitors Cysteine protease Drug screening NMR spectroscopy (Nuclear Magnetic Resonance) Biaryl IC50 (Half-Maximal Inhibitory Concentration) Selectivity Index Ki (Inhibition constant) Diffraction pattern Proteolytic cleavage