Characterization and Purification

Biological testing Structure-Activity Relationship (SAR) Analysis Clinical Trials Biological Evaluation Safety and Toxicity Assessment Lead Compound Selection Iterative Optimization Designing the Scaffold Functional Group Analysis Synthesis of the Scaffold Introducing Diversity Formation of the Macrocyclic Ring Scale-Up and Formulation Chiral starting material Protection of Chiral Starting Material Formation of the Thiirane Ring Introduction of the Sulfonamide Group Introduction of the Phenoxyphenyl Group Chiral Resolution (if needed) Optimization and Derivatization Scale-up and Production (if necessary) Resolution of Enantiomers Chiral Synthon Selection Introduction of the Chirality Conversion to Octahydro-2H-Pyrido<1,2-a>Pyrazine