Construction of the Core Structure

Asymmetric synthesis Characterization Purification Retrosynthetic analysis Purification and characterization Introduction of chirality Functional group manipulation Final steps Scale-up Purification and Isolation Stereochemical Control Biological Evaluation Ring Formation Synthesis of Fragments Late-Stage Intermediate Assembly Installation of Functional Groups Completion of the Synthesis Verification of Biological Activity Late-Stage Functionalization Functional Group Transformations Protection and Deprotection Final steps and purification Assembly of Fragments Acetylenic Sulfoxide Synthesis Asymmetric Synthesis of Chiral Building Blocks Introduction of Functional Groups Formation of the Spirooxazine Ring Introduction of Side Chains and Functional Groups Late-Stage Functionalizations and Final Steps Verification and Characterization Functional Group Adjustments Database Searches Journals Authors Citations