Synthesis of Fragments

Retrosynthetic analysis Late-Stage Intermediate Assembly Construction of the Core Structure Installation of Functional Groups Completion of the Synthesis Purification and characterization Verification of Biological Activity Stereochemical Considerations Ring Construction Functional Group Transformations Protecting groups Sequential Assembly Purification and Analysis Iterative Process Final steps Characterization Scale-up Design of Key Intermediates Assembly of Key Intermediates Macrocyclization Purification Biological testing Optimization and Scale-Up Stereochemistry Control Ring Formation Coumarin and Lignan Connection Final Steps and Adjustments Analysis and Confirmation Oxidative C-N Bond Formation Assembly of Fragments Elaboration and Final Steps Formation of Key Bonds Purification and Isolation Spectroscopic and Analytical Confirmation Yield Optimization Assembling Intermediates Final Purification Characterization and Verification Selection of Key Reactions Optimization Final assembly Deprotection and final adjustments Designing Key Reactions Bond Formation Scale-up and optimization functional group interconversions Coupling reactions Biological Evaluation