One common method involves the cyclization of amino acid derivatives such as N-Boc protected amino acids. By selectively protecting and activating functional groups, the amino acid precursor can be cyclized to form the 4-amino-2(5H)-furanone ring.
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(Z)-3-Amino-3-[1-(2-ethoxy-ethoxy)-cyclohexyl]-acrylic acid tert-butyl ester
