Tetrahedron Letters p. 2459 - 2462 (1985)
Update date:2022-07-29
Topics: Transition Metal-Catalyzed Reactions Multicomponent Reactions (MCRs) Ring-Closing Reactions Enzymatic Synthesis
Hiyama, Tamejiro
Oishi, Haruhito
Saimoto, Hiroyuki
Two new efficient methods are disclosed for the synthesis of the title compounds: (1) base-promoted ring closure of 2-acyloxy alkanenitrile and (2) acid-mediated lactonization of t-butyl-4-alkoxy-3-amino-2-alkenoates.
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