Functional Group Modifications

Characterization Selectivity Stereochemistry Optimization Pharmacophore pharmacokinetic properties Deprotection Biological testing Structure-activity relationships Analogues Purification Protection of Functional Groups Structural Elaboration Starting Material Purification and characterization Structure-Activity Relationship (SAR) Studies Clinical Trials Scale-up In Vivo Studies Mechanism of Action Design Virtual Screening Regulatory Approval Starting Material Selection Iterative Process Substituent Effects Computational Modeling De-Protection Toxicity and Safety Formulation Protection of the Amino Group In Vitro and In Vivo Testing Core Structure In Vitro Studies Pharmacokinetic Optimization Synthesis of Intermediates Linker Length and Flexibility Toxicology and Safety Assessment Pharmacophore Identification