Stereospecific synthesis of novel 1,3-thiazolidin-2-yl analogues of pseudouridine

DOI: 10.1248/cpb.43.1601

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1601 - 1603 (1995)

Update date:2022-08-04

Topics: Characterization Optimization Purification Protection of Functional Groups Starting Material Scale-up De-Protection Functional Group Modifications

Authors:

Inaba Inaba

Inami Inami

Kimoto Kimoto

Yanada Yanada

Miwa Miwa

Taga Taga

Bessho Bessho

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Article abstract of DOI:10.1248/cpb.43.1601

The stereospecific synthesis is described of the first member of a new class of C-nucleoside analogues in which the sugar ring is replaced with a 1,3-thiazolidine ring. The 1,3-thiazolidin-2-yl analogues (1) and (2) of pseudouridine were prepared stereospecifically via condensation of L or D- cysteine with a formylated nucleobase.

Full text of DOI:10.1248/cpb.43.1601

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