To add the N-acetylglucosamine residue at the reducing end, you'll perform a glycosylation reaction. This involves coupling the protected hyaluronic acid fragment with a protected N-acetylglucosamine derivative. Activating agents like DCC (dicyclohexylcarbodiimide) and HOBt (1-hydroxybenzotriazole) are typically used. The reaction should be carefully monitored to ensure regioselectivity.
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4-methoxyphenyl O-(β-D-glucopyranosyluronic acid)-(1->3)-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-(1->4)-O-(β-D-glucopyranosyluronic acid)-(1->3)-2-acetamido-2-deoxy-β-D-glucopyranoside
C16H18O3
C55H46O12
Chloro-acetic acid (2R,3R,4S,5R,6R)-4-benzyloxy-5-hydroxy-6-hydroxymethyl-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-3-yl ester
Acetic acid (2S,3R,4R,5R,6S)-3-acetoxy-6-{(2S,3R,4S,6S)-4-benzyloxy-6-[(2S,3S,4S,6R)-6-benzyloxy-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yloxy]-2-methyl-tetrahydro-pyran-3-yloxy}-5-iodo-2-methyl-tetrahydro-pyran-4-yl ester
dimethylthexylsilyl O-(methyl 2-O-levulinoyl-3-O-benzyl-4-O-(9-O-fluorenylmethoxycarbonyl)-β-D-glucopyranosyluronate)-(1->4)-O-2-azido-3-O-benzyl-2-deoxy-6-O-acetyl-β-D-glucopyranoside
2',4',6'-Trimethoxyphenyl 2,3,4,6-tetra-O-benzyl-1-thio-β-D-glucopyranoside
D-Glucal
NaH
p-tolyl 2-O-(4-methoxybenzyl)-1-thio-β-D-fucopyranoside
NaH
Toluene
4-METHOXY-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE
Nγ-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-Nα-(fluoren-9-ylmethoxycarbonyl)-L-asparagine pentafluorophenyl ester
C62H54O17
BnBr
Pyridine
propargyl 3-O-benzoyl-4,6-O-benzylidene-β-D-glucopyranoside
phenyl 2,3-di-O-benzyl-4-O,6-S-benzylidene-1,6-dithio-α-D-mannopyranoside
water
Triethylamine
methyl 6-deoxy-α/β-D-galactopyranoside
5,4'-di-O-hexanoylgenistein-7-yl 2'',3'',4'',6''-tetra-O-acetyl-β-D-glucopyranoside
2,3,4,6-TETRA-O-BENZOYL-ALPHA-D-GLUCOPYRANOSYL P-TRIFLUOROMETHYLBENZYLTHIO-N-(P-TRIFLUOROMETHYLPHENYL)FORMIMIDATE
3,4,6-Tri-O-acetyl-α-D-galactopyranose 1,2-(endo-methyl orthoacetate)
(2-acetamido-4,6-di-O-acetyl-2-deoxy-3-O-methyl-α-D-galactopyranosyl)-(1<*>3)-
1,3,4,6-tetra-O-acetyl-2-O-benzoyl-α-D-galactopyranose
perilloside A
4-nitrophenyl O-α-L-fucopyranosyl-(1->3)-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-(1->3)-O-β-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-β-D-glucopyranoside
4-Methoxy-benzoic acid (2R,3R,4S,5R,6R)-2-((2R,3S,4S,5R,6S)-5-benzoyloxy-3-benzyloxy-4-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethoxy)-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-3-yl ester
phenyl (2-O-acetyl-3,4,6,-tri-O-benzyl-α-D-mannopyranosyl-(1->3)-2,4,6-tri-O-acetyl-1-thio-α-D-mannopyranoside)
methyl 2,3,4-tri-O-benzyl-6-O-
Acetic acid (2R,3R,4S,5R)-2-acetoxymethyl-4,5-bis-methoxycarbonyloxy-6-(2,2,2-trifluoro-N-phenyl-acetimidoyloxy)-tetrahydro-pyran-3-yl ester
Iodine
acetonitrile
O5'-(2-hexopyranosyloxy-1,2-dihydroxy-diphosphoryl)-guanosine
O-[3-O,4-O,6-O-Triacetyl-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-N-[(phenylmethoxy)carbonyl]-L-serine methyl ester
4-Imidazolidinone, 3-(4-methylphenyl)-2-thioxo-
7-C-(2-buten-4-olid-4-yl)-6-deoxy-1,2:3,4-di-O-isopropylidene-DL-glycero-α-D-galacto-heptopyranose
1,2-O-(2,3,4,6-O-tetra-O-benzyl-D-glucopyranosylidene)-trans-1,2-cyclohexanediol
1,1-CYCLOPROPANEDICARBOXYLIC ACID MONOETHYL ESTER
4,6:4',6'-di-O-benzylidene-3,3'-di-O-(tetrahydropyran-2-yl)-2,2'-di-O-(trifluoromethylsulfonyl)-α,α-trehalose
Carminic Acid
1-(3-bromoprop-1-yn-1-yl)-3-fluorobenzene
n-pent-4-enyl 2-O-benzoyl-3,4,6-tri-O-benzyl-α-D-mannopyranoside
methyl 2,4-di-O-benzyl-3-O-<2,4-di-O-benzyl-3,6-di-O-(3,4,6-tri-O-benzyl-α-D-mannopyranosyl)-α-D-mannopyranosyl>-6-O-(3,4,6-tri-O-benzyl-α-D-mannopyranosyl)-α-D-mannopyranoside
Pseudo-β-L-idopyranose-pentaacetat
ethyl 6-O-tert-butyldiphenylsilyl-2-deoxy-2-phthalimido-1-thio-β-glucopyranoside
benzyl 3β-(2-chloroacetyloxy)olean-12-en-28-oate
2-benzoyl-3,3-di(methylthio)acrylonitrile
6-(p-tolylsulfonyloxy)hexyl 2,3,4,6-tetra-O-acetyl-1-thio-α-D-mannopyranoside
[(2S,3R,4R,5S)-4-Benzyloxy-2-methoxy-5-(4-methoxy-benzyloxy)-6-methylene-tetrahydro-pyran-3-yl]-(4-methoxy-benzyl)-carbamic acid benzyl ester
1H-Pyrrole-1,2-dicarboxylic acid, 2,5-dihydro-, 2-ethyl 1-(phenylmethyl) ester, (R)-
8-ethoxycarbonyloctyl O-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)-(1->6)-2,4-di-O-benzyl-β-D-mannopyranoside
(2R,3R,4S,5S,6R)-2-(acetoxymethyl)-6-(2-(2-(2-azidoethoxy)ethoxy)ethoxy) tetrahydro-2H-pyran-3,4,5-triyl triacetate
(2S,4aS,5R,8aR)-N-phenoxycarbonyl-2-propyl-5-methyl-decahydroquinolin-4-one
methyl 3,6-di-O-benzyl-2-O-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-β-D-mannopyranoside
