Hydrolysis resistance

Kinetic studies Synthetic route Steric hindrance Cytotoxicity In vitro Testing In Vivo Testing Pyrimidines Nucleophilic Attack Electronic effects Substrate Scope Computational Modeling Structure-Activity Relationship (SAR) Antiviral Activity Reaction Monitoring Base-Catalyzed Hydrolysis Anticancer activity Phosphorylation Bioavailability Spectroscopic Analysis Ring Strain Symmetrical Purines Bicyclic System Amide bond Prodrug Phosphonate Nucleoside analogs pH dependence Control experiment Isolation of intermediates Enzymatic stability