Peptides can bind to proteins in the bloodstream, which can reduce their bioavailability. Strategies to mitigate this issue include optimizing the peptide structure to reduce protein binding or designing prodrugs that release the active peptide after absorption.
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N-(tert-butoxycarbonyl)histidine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane
(SS,E)-N-(3-(3,4-dichlorophenyl)propylidene)-2-methylpropane-2-sulfinamide
