Off-target effects

Unintended interactions of the ribozyme with non-target RNA sequences.

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2-C-Methyluridine modified hammerhead ribozyme against the estrogen receptor
Related Chemicals
- 2',3'-di-O-benzoyl-5'-O-(4-methoxytrityl)-2'-C-methyluridine
PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor
Related Chemicals
- (S_S,E)-N-(3-(3,4-dichlorophenyl)propylidene)-2-methylpropane-2-sulfinamide

Selectivity Hydrolysis IC50 binding affinity Enzyme inhibition In Vivo Studies Protein Binding Preclinical Studies Bioavailability Thermodynamic Stability In Vitro Studies Metabolic Stability Gel Electrophoresis Toxicity Profile Dose-response relationship Luciferase assay Western blot Pharmacokinetics (PK) Half-life (t?) Transfection Estrogen Receptor (ER) EC50 Pharmacodynamics (PD) Mechanism of Action (MoA)

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