Pharmacodynamics (PD)

Study of drug effects on biological systems, including mechanism of action.

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Synthesis QSAR (quantitative structure-activity relationship) Heterocyclic compounds Selectivity Molecular docking Hydrolysis IC50 Pharmacophore Cytotoxicity binding affinity antimicrobial agents Minimum inhibitory concentration (MIC) Enzyme inhibition In vitro Testing In Vivo Testing Biological Evaluation In Vivo Studies Lead Optimization Zone of Inhibition Virtual Screening Protein Binding Preclinical Studies Resistance Structure-Activity Relationship (SAR) Antiviral Activity Enzyme Kinetics Drug Resistance Drug Repurposing MIC Determination Bioavailability Mycobacterium tuberculosis In Vitro Studies In Silico Studies Antitubercular Agents Metabolic Stability Antifungal Activity Scaffold Hopping Toxicity Profile Bioisosteres Dose-response relationship Quinazolinones Docking simulation Gram-positive bacteria Gram-negative bacteria MIC assay Drug-likeness Antibacterial spectrum ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) Pharmacokinetics (PK) Half-life (t?)

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