Side-chain protection

Temporary blocking of reactive side-chain groups (e.g., –OH, –NH?) to prevent interference during synthesis.

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Solid-phase synthesis Yield Cleavage Mass spectrometry (MS) Photolysis Deprotection HPLC (high-performance liquid chromatography) NMR (nuclear magnetic resonance) Peptide Synthesis Coupling Solid-Phase Peptide Synthesis (SPPS) Coupling Reaction Orthogonal Protection Activation Quantum Yield UV Irradiation Threonine Side Reactions Purity serine Resin Linker Photodeprotection NMR spectroscopy (Nuclear Magnetic Resonance) Fmoc (Fluorenylmethyloxycarbonyl) TFA (Trifluoroacetic Acid) HOBt (Hydroxybenzotriazole) Resin (Solid Support) DIC (Diisopropylcarbodiimide) Secondary Structure Activating agent Oligopeptide Photoproduct

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