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Tyramine hydrochloride

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Name

Tyramine hydrochloride

EINECS 200-462-5
CAS No. 60-19-5 Density 1.103 g/cm3
PSA 46.25000 LogP 2.39570
Solubility N/A Melting Point 253-255 °C(lit.)
Formula C8H12ClNO Boiling Point 325.2 °C at 760 mmHg
Molecular Weight 173.642 Flash Point 119.2 °C
Transport Information N/A Appearance off-white to light yellow powder
Safety 22-24/25-36-26 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 60-19-5 (Tyramine hydrochloride) Hazard Symbols IrritantXi
Synonyms

Phenol,4-(2-aminoethyl)-, hydrochloride (9CI);Phenol, p-(2-aminoethyl)-,hydrochloride (8CI);2-(4-Hydroxyphenyl)ethylamine hydrochloride;4-Hydroxy-b-phenethylamine hydrochloride;4-Hydroxyphenethylamine hydrochloride;Mydrial;Tyrosam;Uteramin;p-Tyramine hydrochloride;

Article Data 14

Tyramine hydrochloride Synthetic route

14191-95-8

4-cyanomethylphenol

60-19-5

tyramine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; 1% Pd/C; hydrogen In ethanol; water under 2585.81 Torr; for 12h;95%
2982-55-0

1-benzyloxy-4-(2-nitroethenyl)benzene

60-19-5

tyramine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; palladium on activated charcoal In ethanol at 0℃; under 760 Torr;94%

p-hydroxyphenyl-α-isonitrosoacetophenone

60-19-5

tyramine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; palladium In indication of hydrogen; water85%

C22H31NO

60-19-5

tyramine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In propan-1-ol at 190℃; for 0.0833333h; Microwave irradiation; Green chemistry;81%

C20H25NO2

60-19-5

tyramine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In propan-1-ol at 190℃; for 0.0833333h; Microwave irradiation; Green chemistry;76%
60-18-4

L-tyrosine

60-19-5

tyramine hydrochloride

Conditions
ConditionsYield
Stage #1: L-tyrosine With (R)-Carvone In propan-1-ol at 190℃; under 11251.1 Torr; for 0.666667h; Sealed tube;
Stage #2: With hydrogenchloride In propan-1-ol; water at 190℃; for 0.0833333h;
67%
Multi-step reaction with 2 steps
1: propan-1-ol / 20 - 190 °C / Green chemistry
2: hydrogenchloride / propan-1-ol / 0.67 h / 190 °C / Green chemistry
View Scheme

C18H23NO

60-19-5

tyramine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In propan-1-ol at 190℃; for 0.666667h; Temperature; Green chemistry;67%
76457-44-8

anti-2-(p-Hydroxyphenyl)glyoxal-1-oxim

60-19-5

tyramine hydrochloride

Conditions
ConditionsYield
66%

C25H27Cl2NO

60-19-5

tyramine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In propan-1-ol at 190℃; for 0.0833333h; Microwave irradiation; Green chemistry;64%

p-hydroxyphenyl-α-isonitrosoacetophenone

64-17-5

ethanol

60-19-5

tyramine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; palladium In water2%

Tyramine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Tyramine hydrochloride Specification

The tyramine monochloride , with the CAS register number 60-19-5, has other names as 2-(3-indolyl)ethylamine hydrochloride ; 3-(2-aminoethyl)indole hcl;tryptamine hcl ; tryptamine hydrochloride ; timtec-bb sbb000359 ; 4-(2-aminoethyl)-phenohydrochloride ; p-(2-aminoethyl)-phenomonohydrochloride ; phenol,4-(2-aminoethyl)-,hydrochloride .

The characteristics of this chemical are as the following: (1)#H bond acceptors:  2  ; (2)#H bond donors:  3  ; (3)#Freely Rotating Bonds:  4 ; (4)Polar Surface Area:  12.47   ; (5)Index of Refraction:  1.577  ; (6)Molar Refractivity:  41.21 cm ; (7)Molar Volume:  124.3 cm3  ; (8)Polarizability:  16.34 ×10-24 cm ; (9)Surface Tension:  48.3 dyne/cm  ; (10)Density:  1.103 g/cm3  ; (11)Flash Point:  119.2 °C  ; (12)Enthalpy of Vaporization:  58.99 kJ/mol  ; (13)Boiling Point:  325.2 °C at 760 mmHg  ; (14)Vapour Pressure:  0.000123 mmHg at 25°C .

It is a off-white to light yellow powder and it is hygroscopic. Being a kind of irritant chemical to eyes, respiratory system and skin, it may cause inflammation to the skin or other mucous membranes. So while dealing with this chemcial, we need to be very careful. Wear suitable protective clothing and if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, avoid contact with skin and eyes and do not breathe dust. If you need more safety information, you could refer to the WGK Germany  3. When store it, you should keep it at RT. What's more, its product categories are including anilines, aromatic amines and nitro compounds;amines;aromatics.

In addition, you could refer to the following data information to get the molecular structure:
SMILES:Oc1ccc(cc1)CCN
InChI:InChI=1/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
InChIKey:DZGWFCGJZKJUFP-UHFFFAOYAB

Below are the toxicity information of this kind of chemical:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo subcutaneous 1044mg/kg (1044mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 47, Pg. 339, 1933.
mouse LD50 intraperitoneal 710mg/kg (710mg/kg)   Toxicology and Applied Pharmacology. Vol. 28, Pg. 227, 1974.
 
mouse LD50 intravenous 208mg/kg (208mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
European Journal of Pharmacology. Vol. 9, Pg. 289, 1970.
 
mouse LDLo unreported 2750mg/kg (2750mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 126, 1916

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