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Conditions | Yield |
---|---|
With pyridoxal 5'-phosphate; aromatic L-amino acid decarboxylase In various solvent(s) at 30℃; for 48h; | 99% |
at 300 - 340℃; | |
Bestrahlen der Kristalle mit Roentgen-Strahlen; |
Conditions | Yield |
---|---|
With ammonium bromide; ethylenediamine at 80℃; for 5h; Microwave irradiation; Inert atmosphere; neat (no solvent); | 98% |
With recombinant Arabidopsis thaliana histone deacetylase 14 In aq. buffer at 30℃; pH=8; Reagent/catalyst; Enzymatic reaction; |
Conditions | Yield |
---|---|
With acetic acid In methanol for 2h; Ambient temperature; Irradiation; other N-subsituted amides of o-hydroxy-trans-cinnamic acid; | A 95% B 100 % Spectr. |
N-{2-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethyl}formamide
tyrosamine
Conditions | Yield |
---|---|
With ethanol; sodium hydroxide at 78℃; for 8h; Reagent/catalyst; Temperature; | 87% |
1-(benzyloxy)-4-(2-nitroethyl)benzene
tyrosamine
Conditions | Yield |
---|---|
With ethanol; hydrogen at 100℃; Flow reactor; | 85% |
Conditions | Yield |
---|---|
Stage #1: formic acid; phenol With boron trifluoride In diethyl ether at 15℃; for 2h; Stage #2: nitromethane With ammonium acetate In diethyl ether at 110℃; for 2h; Stage #3: With hydrogen In ethanol at 50℃; for 4h; Temperature; | 82.3% |
Conditions | Yield |
---|---|
With 1,10-Phenanthroline; copper hydroxide In 1-methyl-pyrrolidin-2-one at 210℃; for 5h; Inert atmosphere; Green chemistry; | 68% |
in Gegenwart von Fleischbruehe; | |
at 270℃; |
(4-Hydroxyphenyl)acetaldehyd-dimethylhydrazon
tyrosamine
Conditions | Yield |
---|---|
With hydrogen; rhenium; nickel In methanol under 760 Torr; for 12h; Ambient temperature; | 58% |
N-(p-hydroxyphenylethyl)-N-(6-bromo-3-hydroxy-4-methoxybenzyl)amine
A
tyrosamine
B
2-bromoisovanillin
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor In 1,4-dioxane at 25℃; for 3h; pH=4.5; | A 33% B 37% C 8% |
p-Aminophenethylamine
tyrosamine
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite | |
With hydrogenchloride; tin(IV) chloride; sodium nitrite anschliessend Erwaermen; |
The IUPAC name of Tyramine is 4-(2-aminoethyl)phenol. With the CAS registry number 51-67-2, it is also named as Benzeneethanamine, 4-hydroxy-. The product's categories are Anilines, Aromatic Amines and Nitro Compounds. Besides, it is white to light beige solid, which should be stored in sealed, dark place. It is stable and incompatible with strong acids, strong oxidizing agents. In addition, its molecular formula is C8H11NO and molecular weight is 137.18.
The other characteristics of this product can be summarized as: (1)EINECS: 200-115-8; (2)ACD/LogP: 0.72; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -2.36; (5)ACD/LogD (pH 7.4): -1.82; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 1; (10)#H bond acceptors: 2; (11)#H bond donors: 3; (12)#Freely Rotating Bonds: 4; (13)Index of Refraction: 1.577; (14)Molar Refractivity: 41.21 cm3; (15)Molar Volume: 124.3 cm3; (16)Surface Tension: 48.3 dyne/cm; (17)Density: 1.103 g/cm3; (18)Flash Point: 119.2 °C; (19)Melting point: 155-163 °C; (20)Water Solubility: 1g / 95mL (15 °C); (21)Enthalpy of Vaporization: 58.99 kJ/mol; (22)Boiling Point: 325.2 °C at 760 mmHg; (23)Vapour Pressure: 0.000123 mmHg at 25 °C.
Preparation of Tyramine: this chemical occurs widely in plants and animals and is metabolized by the enzyme monoamine oxidase. Moreover, it is often produced by the decarboxylation of tyrosine during fermentation or decay. It also can be produced by the deoxidization of P-Hydroxybenzyl cyanide.
Uses of Tyramine: this chemical is used as intermediate of Bezafibrate. It is also used in organic synthesis. It can be used for the contraction of uterus, peripheral nerves, and for elevation of blood pressure in medical treatment. Additionally, it can react with Formaldehyde to get 4-(2-Dimethylamino-ethyl)-phenol.
This reaction needs H2, 10 percent Pd/C and Methanol at temperature of 20 °C. The yield is 93 %.
When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing, gloves and eye/face protection.
People can use the following data to convert to the molecule structure.
(1)SMILES: Oc1ccc(cc1)CCN
(2)InChI: InChI=1/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
(3)InChIKey: DZGWFCGJZKJUFP-UHFFFAOYAB
(4)Std. InChI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
(5)Std. InChIKey: DZGWFCGJZKJUFP-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | subcutaneous | 30mg/kg (30mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1412, 1935. | |
mouse | LD50 | intracervical | 30mg/kg (30mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Tohoku Yakka Daigaku Kenkyu Nempo. Annual Report of the Tohoku College of Pharmacy. Vol. 27, Pg. 131, 1980. |
mouse | LD50 | intravenous | 229mg/kg (229mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Acta Pharmacologica et Toxicologica. Vol. 38, Pg. 474, 1976. |
mouse | LDLo | intraperitoneal | 800mg/kg (800mg/kg) | Journal of Physiology. Vol. 76, Pg. 224, 1932. | |
mouse | LDLo | subcutaneous | 225mg/kg (225mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. -, 1965. | |
mouse | LDLo | unreported | 2200mg/kg (2200mg/kg) | AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 153, Pg. 161, 1930. |
rabbit | LD50 | intravenous | 300mg/kg (300mg/kg) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 691, 1986. |