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| CAS No.: | 1075-61-2 |
|---|---|
| Name: | 3-(2-aminopropyl)phenol |
| Molecular Structure: | |
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| Formula: | C9H13 N O |
| Molecular Weight: | 151.208 |
| Synonyms: | Phenol,m-(2-aminopropyl)- (6CI,7CI,8CI); (?à)-Desoxymetaraminol; 3-(2-Aminopropyl)phenol; 3-Hydroxy-a-methylphenethylamine;dl-m-Hydroxyamphetamine; a-Methyl-m-tyramine |
| Density: | 1.07g/cm3 |
| Melting Point: | 137 °C |
| Boiling Point: | 281°Cat760mmHg |
| Flash Point: | 123.7°C |
| Safety: | Poison by subcutaneous and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 46.25000 |
| LogP: | 1.98220 |
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(1R,S)-1-[3-(benzyloxy)phenyl]propan-2-amine
- 1075-61-2
Desoxy metaraminol
| Conditions | Yield |
|---|---|
| With palladium on activated charcoal; hydrogen In methanol | 99% |
- 17862-85-0
3-methoxyamphetamine
- 1075-61-2
Desoxy metaraminol
| Conditions | Yield |
|---|---|
| With hydrogen bromide In water for 4h; Solvent; Reflux; | 88.5% |
| With hydrogenchloride at 160℃; |
- 61131-60-0
3-(2-nitropropyl-1-en-1-yl)phenol
- 1075-61-2
Desoxy metaraminol
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 80℃; for 2h; | 71% |
- 61227-51-8
3-(3-methoxyphenyl)-2-methylpropionic acid
- 1075-61-2
Desoxy metaraminol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: sodium hydroxide; aqueous ammonia; thionyl chloride 2: bromine; aqueous KOH-solution / anschliessend Erwaermen mit Natriumhydroxid versetzten Reaktionsgemisches 3: aqueous hydrochloric acid / 160 °C View Scheme |
- 310873-75-7
3-(3-methoxy-phenyl)-2-methyl-propionic acid amide
- 1075-61-2
Desoxy metaraminol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: bromine; aqueous KOH-solution / anschliessend Erwaermen mit Natriumhydroxid versetzten Reaktionsgemisches 2: aqueous hydrochloric acid / 160 °C View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: ammonium acetate; acetic acid / 6 h / 80 °C 2.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C 2.2: 24 h / 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 20 °C 3.2: 0 °C 4.1: palladium on activated charcoal; hydrogen / methanol View Scheme | |
| Multi-step reaction with 2 steps 1: acetic acid; ammonium acetate / 6 h / 80 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 80 °C View Scheme |
- 1075-61-2
Desoxy metaraminol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C 1.2: 24 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 20 °C 2.2: 0 °C 3.1: palladium on activated charcoal; hydrogen / methanol View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: ethylene dibromide; magnesium / tetrahydrofuran; diethyl ether / 1.33 h / 20 - 30 °C / Reflux 2: triethylamine; dmap / tetrahydrofuran / 8 h / 5 - 10 °C / Inert atmosphere 3: ammonia / methanol / 16 h / 75 °C / Autoclave 4: hydrogen bromide / water / 4 h / Reflux View Scheme |
- 34322-78-6
1-(3-methoxyphenyl)isopropanol
- 1075-61-2
Desoxy metaraminol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: triethylamine; dmap / tetrahydrofuran / 8 h / 5 - 10 °C / Inert atmosphere 2: ammonia / methanol / 16 h / 75 °C / Autoclave 3: hydrogen bromide / water / 4 h / Reflux View Scheme |
- 872548-72-6
1-(3-methoxyphenyl)-2-methanesulfonyloxypropane
- 1075-61-2
Desoxy metaraminol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: ammonia / methanol / 16 h / 75 °C / Autoclave 2: hydrogen bromide / water / 4 h / Reflux View Scheme |
- Total:24 Page 1 of 1 1
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Chemistry
Product Name: Gepefrine
CAS Registry Number: 1075-61-2
IUPAC Name: 3-(2-aminopropyl)phenol
Molecular Weight: 151.20562 [g/mol]
Molecular Formula: C9H13NO
XLogP3: 1.4
H-Bond Donor: 2
H-Bond Acceptor: 2
Surface Tension: 44.6 dyne/cm
Density: 1.07 g/cm3
Flash Point: 123.7 °C
Enthalpy of Vaporization: 54.07 kJ/mol
Boiling Point: 281 °C at 760 mmHg
Vapour Pressure: 0.00215 mmHg at 25°C
Following is the molecular structure of Gepefrine (CAS NO.1075-61-2) is:
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 82mg/kg (82mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 219, 1965. |
| mouse | LD50 | subcutaneous | 17100ug/kg (17.1mg/kg) | BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 219, 1965. |
| rat | LDLo | intravenous | 70mg/kg (70mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 101, 1948. |
Safety Profile
Poison by subcutaneous and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
Specification
Gepefrine , its cas register number is 1075-61-2. It also can be called 3-13-00-01706 (Beilstein Handbook Reference) ; BRN 2082934 ; EINECS 214-056-0 ; alpha-Methyl-m-tyramine ; alpha-Mmtyr ; m-(2-Aminopropyl)phenol ; 3-(2-Aminopropyl)phenol ; Phenol, m-(2-aminopropyl)- .