Products Categories
CAS No.: | 13423-73-9 |
---|---|
Name: | 3,5-Diisopropyl-4-hydroxybenzoic acid |
Article Data: | 13 |
Molecular Structure: | |
Formula: | C13H18O3 |
Molecular Weight: | 222.284 |
Synonyms: | Propofol 4-Carboxylic Acid;Benzoic acid,4-hydroxy-3,5-bis(1-methylethyl);4-hydroxy-3,5-diisopropyl-benzoic acid;4-carboxy-2,6-di-isopropylphenol;4-Hydroxy-3,5-diisopropyl-benzoesaeure;3,5-Diisopropyl-4-hydroxybenzoic acid;BENZOIC ACID,3,5-DIISOPROPYL-4-HYDROXY; |
Density: | 1.108g/cm3 |
Melting Point: | 146 °C |
Boiling Point: | 343.5°Cat760mmHg |
Flash Point: | 175.7°C |
PSA: | 57.53000 |
LogP: | 3.33720 |
isopropyl alcohol
4-hydroxy-benzoic acid
3,5-diisopropyl p-hydroxybenzoic acid
Conditions | Yield |
---|---|
With sulfuric acid In water at 5 - 60℃; Large scale; | 84% |
at 40 - 60℃; Microwave irradiation; | 78% |
Stage #1: isopropyl alcohol; 4-hydroxy-benzoic acid With sulfuric acid In water at 15 - 65℃; for 4h; Friedel Crafts Alkylation; Stage #2: In water | 74.6% |
3,5-diisopropyl-4-hydroxybenzaldehyde
3,5-diisopropyl p-hydroxybenzoic acid
Conditions | Yield |
---|---|
With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene In tetrahydrofuran; water; butan-1-ol at 20℃; for 16h; | 68% |
2,6-diisopropylphenol
3,5-diisopropyl p-hydroxybenzoic acid
Conditions | Yield |
---|---|
With hydrogenchloride; sodium methylate In N,N-dimethyl acetamide; water | 23% |
Multi-step reaction with 2 steps 1: acetic acid / water / 6 h / Reflux 2: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; tetrahydrofuran; butan-1-ol / 16 h / 20 °C View Scheme |
carbon dioxide
3,5-diisopropyl p-hydroxybenzoic acid
di-isopropyl ether
4-hydroxy-benzoic acid
3,5-diisopropyl p-hydroxybenzoic acid
Conditions | Yield |
---|---|
With sulfuric acid at 10 - 65℃; Friedel-Crafts Alkylation; | 120 g |
3,5-diisopropyl p-hydroxybenzoic acid
2,6-diisopropylphenol
Conditions | Yield |
---|---|
Stage #1: 4-hydroxy-3,5-diisopropylbenzoic acid; sodium hydroxide In ethylene glycol at 140 - 145℃; for 7h; Inert atmosphere; Stage #2: With hydrogenchloride In water; ethylene glycol for 1h; pH=1 - 2; | 93.5% |
With decarboxylase at 25℃; for 15h; pH=6.5; Enzymatic reaction; | 80.3% |
With sodium hydroxide In 2-ethoxy-ethanol at 125 - 130℃; Large scale; | 74% |
Stage #1: 4-hydroxy-3,5-diisopropylbenzoic acid With sodium hydroxide In ethylene glycol at 140 - 145℃; Stage #2: With hydrogenchloride In water; ethylene glycol at 20℃; for 0.5h; pH=1 - 2; | 53 g |
3,5-diisopropyl p-hydroxybenzoic acid
benzyl bromide
benzyl 3,5-diisopropyl-4-hydroxybenzoate
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water; N,N-dimethyl-formamide; acetonitrile | 79% |
Conditions | Yield |
---|---|
Stage #1: 4-hydroxy-3,5-diisopropylbenzoic acid With toluene-4-sulfonic acid In para-xylene at 60℃; for 1.5h; Stage #2: hydroquinone In para-xylene at 110℃; for 16h; | 61.5% |
3,5-diisopropyl p-hydroxybenzoic acid
allyl bromide
4-Allyloxy-3.5-diisopropyl-benzoesaeure
Conditions | Yield |
---|---|
With sodium methylate |
3,5-diisopropyl p-hydroxybenzoic acid
4-Allyloxy-3.5-diisopropyl-benzoesaeure-aethylester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOMe 2: (i) SOCl2, (ii) /BRN= 1718733/, Py View Scheme |