Products Categories
| CAS No.: | 137234-74-3 |
|---|---|
| Name: | 4-Chloro-6-ethyl-5-fluoropyrimidine |
| Article Data: | 13 |
| Molecular Structure: | |
|
|
|
| Formula: | C6H6ClFN2 |
| Molecular Weight: | 160.578 |
| Synonyms: | Pyrimidine,4-chloro-6-ethyl-5-fluoro-; |
| EINECS: | 604-010-1 |
| Density: | 1.286 g/cm3 |
| Boiling Point: | 210.913 °C at 760 mmHg |
| Flash Point: | 81.358 °C |
| Hazard Symbols: | 20/21/22-36/37/38:; |
| Risk Codes: | 20/21/22-36/37/38 |
| Safety: | 22-36/37/39-45 |
| PSA: | 25.78000 |
| LogP: | 1.83150 |
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 173606-50-3BOC-10-AMINODECANOIC ACID
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 137234-87-8
6-ethyl-5-fluoropyrimidin-4(1H)-one
- 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine
| Conditions | Yield |
|---|---|
| With triethylamine; trichlorophosphate In dichloromethane at 48℃; for 6h; Product distribution / selectivity; Industry scale; Heating / reflux; | 99% |
| With triethylamine; trichlorophosphate In dichloromethane for 5h; Product distribution / selectivity; Heating / reflux; | 90% |
| With triethylamine; trichlorophosphate In dichloromethane at 40℃; for 5.16667h; Reflux; |
- 137234-87-8
6-ethyl-5-fluoro-4-hydroxypyrimidine
- 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine
| Conditions | Yield |
|---|---|
| Stage #1: 6-ethyl-5-fluoro-4-hydroxypyrimidine With triethylamine; trichlorophosphate In dichloromethane for 5.5h; Heating / reflux; Stage #2: With hydrogenchloride; water In dichloromethane at 20℃; | 95% |
| With triethylamine; trichlorophosphate In dichloromethane at 40℃; for 8h; Reflux; | 90% |
| With trichlorophosphate In N,N-dimethyl-formamide at 90℃; for 5h; | 90.2% |
- 188416-35-5
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
A
- 86404-63-9
1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
B
- 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 60 - 70℃; Temperature; Reagent/catalyst; Solvent; | A 88.4% B n/a |
- 137234-87-8
6-Ethyl-5-fluoropyrimidin-4(3H)-one
- 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine
| Conditions | Yield |
|---|---|
| With trichlorophosphate Heating; |
- 759-67-1
2-fluoro-3-oxopentanoic acid ethyl ester
- 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 1) MeONa, MeOH 2: POCl3 / Heating View Scheme | |
| Multi-step reaction with 2 steps 1: sodium methylate / methanol / 20 h / 15 °C 2: trichlorophosphate / 3 h / 60 °C View Scheme |
- 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine
- 188416-28-6
1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane
| Conditions | Yield |
|---|---|
| With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane at 55℃; for 16h; Temperature; | 98% |
| With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane for 12h; Reflux; | 95.1% |
| With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane for 12h; Reflux; | 95.1% |
- 106-54-7
p-Chlorothiophenol
- 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine
- 1112937-23-1
4-(4-chloro-phenylsulfanyl)-6-ethyl-5-fluoropyrimidine
| Conditions | Yield |
|---|---|
| With N-ethyl-N,N-diisopropylamine In acetonitrile at 10 - 20℃; for 2h; | 96% |
- 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine
- 4892-02-8
Methyl thiosalicylate
- 1258386-27-4
methyl 2-(6-ethyl-5-fluoropyrimidin-4-yl-sulfanyl)benzoate
| Conditions | Yield |
|---|---|
| Stage #1: Methyl thiosalicylate With sodium hydride In tetrahydrofuran at 5℃; for 0.666667h; Stage #2: 4-chloro-6-ethyl-5-fluoropyrimidine In tetrahydrofuran at 20 - 25℃; | 96% |
- 108-98-5
thiophenol
- 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine
- 1112937-27-5
4-(phenylsulfanyl)-6-ethyl-5-fluoropyrimidine
| Conditions | Yield |
|---|---|
| With N-ethyl-N,N-diisopropylamine In acetonitrile at 10℃; for 2h; | 95% |
- 137234-74-3
4-chloro-5-fluoro-6-ethylpyrimidine
| Conditions | Yield |
|---|---|
| With potassium carbonate In dimethyl sulfoxide at 120℃; for 17.3h; Sealed tube; | 81% |
- 137234-87-84-Ethyl-5-fluoro-6-hydroxypyrimidine
- 137-26-8Tetramethylthiuram Disulfide
- 137330-13-3Tilmicosin phosphate
- 137335-79-6Emamectin
- 137350-66-4MMBC (THIOGLO (R) 1)
- 13736-22-6Sodium 4-formylbenzenesulfonate
- 1373758-54-33-(4-methylphenyl)-5H-1,4,2-dioxazol-5-one
- 13739-35-03-((4-METHYLPHENYL)THIO)PROPIONIC ACID
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
What can I do for you?
Get Best Price
Chemistry
Structure of 4-Chloro-6-ethyl-5-fluoropyrimidine (CAS NO.137234-74-3):
Empirical Formula: C6H6ClFN2
Molecular Weight: 160.5766
Index of Refraction: 1.502
Molar Refractivity: 36.873 cm3
Molar Volume: 124.859 cm3
Polarizability: 14.618×10-24cm3
Surface Tension: 40.592 dyne/cm
Density: 1.286 g/cm3
Flash Point: 81.358 °C
Enthalpy of Vaporization: 42.896 kJ/mol
Boiling Point: 210.913 °C at 760 mmHg
Vapour Pressure: 0.272 mmHg at 25°C
Product Categories: APIs & Intermediate;Pyrimidine
Synonyms of 4-Chloro-6-ethyl-5-fluoropyrimidine (CAS NO.137234-74-3): Pyrimidine,4-chloro-6-ethyl-5-fluoro-
Safety Profile
Risk Statements: 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-36/37/39-45
S22:Do not breathe dust.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)