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CAS No.: | 148893-10-1 |
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Name: | HATU |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C10H15F6N6OP |
Molecular Weight: | 380.233 |
Synonyms: | O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl-uronium hexafluorophosphat;2-(7-Aza-1H-Benzotriazole-1-yl)-1,1,3,3-TetramethyluroniumHexafluorophosphate;1H-1,2,3-Triazolo[4,5-b]pyridinium,1-[bis- (dimethylamino)methylene]-,hexafluorophosphate( 1-),3-oxide; |
EINECS: | 604-662-7 |
Melting Point: | 183-185 °C |
Boiling Point: | 176 °C at 760mmHg |
Solubility: | Soluble in acetonitrile. Insoluble in water. |
Appearance: | White crystalline to off-white powder |
Hazard Symbols: | Xi,Xn |
Risk Codes: | 36/37/38-20/21/22 |
Safety: | 26-37/39-36/37-36 |
PSA: | 72.67000 |
LogP: | 2.82700 |
pyridine-4-carboxylic acid
N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate
Conditions | Yield |
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Stage #1: pyridine-4-carboxylic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 3.25h; Sealed tube; Inert atmosphere; Stage #2: C108H81Fe2N15(4+)*4C2F6NO4S2(1-) In acetonitrile at 20℃; for 72h; | 96% |
4-nitrobenzyl chloride
N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate
3-((4-nitrobenzyl)oxy)-3H-[1,2,3]triazole[4,5-b]pyridine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane Reflux; | 95% |
N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate
Conditions | Yield |
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With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.5h; Darkness; Inert atmosphere; | 95% |
N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20℃; | 91% |
N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate
pyrrole-2-carboxyl acid
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at -30℃; for 1.5h; Inert atmosphere; Schlenk technique; | 90% |
N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In [D3]acetonitrile at 20℃; | 90% |
Molecular Formula: C10H15F6N6OP
Molecular Weight: 380.23 g/mol
Melting point: 183-188 °C (dec.)
Boiling Point: 176 °C at 760mmHg
storage temp. of 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (CAS NO.148893-10-1): 2-8 °C
Appearance: White crystalline to off-white powder
Product Categories of 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (CAS NO.148893-10-1): Peptide coupling agents;Pharmaceutical Intermediates;Amino Acid Derivatives;Coupling Reagent;protected amino acid & peptides;Peptide Coupling Reagents;Peptide
Following is the structure of 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (CAS NO.148893-10-1):
Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-37/39-36/37-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
S36/37:Wear suitable protective clothing and gloves.
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 10-21
2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate , its cas register number is 148893-10-1. It also can be called o-(7-Azabenzotriazol-1-yl)-N,N,N',N'-te-tramethyluronium hexafluorophosphate ; 1H-1,2,3-Triazolo(4,5-b)pyridinium, 1-(bis(dimethylamino)methylene)-, hexafluorophosphate(1-), 3-oxide ; and HATU .