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CAS No.: | 1953-02-2 |
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Name: | Tiopronin |
Article Data: | 22 |
Molecular Structure: | |
Formula: | C5H9NO3S |
Molecular Weight: | 163.197 |
Synonyms: | Glycine,N-(2-mercaptopropionyl)- (7CI,8CI);(2-Mercaptopropionyl)glycine;Acadione;CCRIS 1935;Captimer;Epatiol;MPG;MPG(hepatoprotective);N-(2-Mercaptopropionyl)glycine;Sutilan Cusi;Thiolpropionamidoacetic acid;Thiosol;Tioglis;a-Mercaptopropionyglycine; |
EINECS: | 217-778-4 |
Density: | 1.294 g/cm3 |
Melting Point: | 93-98 °C |
Boiling Point: | 418.3 °C at 760 mmHg |
Flash Point: | 206.8 °C |
Appearance: | white crystalline powder |
Hazard Symbols: | Xn |
Risk Codes: | 22 |
Safety: | 36/37 |
PSA: | 105.20000 |
LogP: | -0.10360 |
2-chloropropionylglycine
N-(2-mercaptopropionyl)glycine
Conditions | Yield |
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Stage #1: 2-chloropropionylglycine With sodium disulfide; sulfuric acid; sodium carbonate In water at 45℃; for 0.05h; Large scale; Stage #2: With sulfuric acid; zinc at 5 - 20℃; for 1.05h; Temperature; Large scale; | 76.5% |
N-(2-bromo-propionyl)-glycine
N-(2-mercaptopropionyl)glycine
Conditions | Yield |
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With hydrogen sulfide; sodium methylate In methanol |
Conditions | Yield |
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With ammonium hydroxide In ethanol |
N-(2-mercaptopropionyl)glycine
Conditions | Yield |
---|---|
With sulfuric acid; zinc |
Conditions | Yield |
---|---|
With ammonium hydroxide for 1h; Ambient temperature; |
Conditions | Yield |
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With ammonia; sodium |
Conditions | Yield |
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In dimethyl sulfoxide at 27.5℃; Equilibrium constant; further solvent; |
Conditions | Yield |
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With sodium carbonate at 0℃; for 5h; | 190 g |
Conditions | Yield |
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In water | 94.4% |
4-(3-Oxo-3H-benzo[d)-isothiazol-2-yl)benzenesulfonamide
N-(2-mercaptopropionyl)glycine
Conditions | Yield |
---|---|
In tetrahydrofuran; methanol at 60℃; for 0.5h; | 93% |
IUPAC Name: 2-(2-Sulfanylpropanoylamino)acetic acid
Synonyms of Meprin (CAS NO.1953-02-2): (2-Mercaptopropionyl)glycine ; Capen ; Captimer ; Epatiol ; Mercaptopropionylglycine ; Tiopronin ; N-(2-Mercapto-1-oxopropyl)glycine ; Tioproninum
CAS NO: 1953-02-2
Molecular Formula: C5H9NO3S
Molecular Weight: 163.19
Molecular Structure:
EINECS: 217-778-4
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 4
Polar Surface Area: 71.91Å2
Index of Refraction: 1.518
Molar Refractivity: 38.25 cm3
Molar Volume: 126 cm3
Surface Tension: 49.9 dyne/cm
Density: 1.294 g/cm3
Flash Point: 206.8 °C
Enthalpy of Vaporization: 73.7 kJ/mol
Boiling Point: 418.3 °C at 760 mmHg
Vapour Pressure: 3.6E-08 mmHg at 25°C
Melting Point: 93-98 °C
Product Categories of Meprin (CAS NO.1953-02-2): Pharmaceutical material and intermeidates
SMILES: O=C(O)CNC(=O)C(S)C
InChI: InChI=1/C5H9NO3S/c1-3(10)5(9)6-2-4(7)8/h3,10H,2H2,1H3,(H,6,9)(H,7,8)
InChIKey: YTGJWQPHMWSCST-UHFFFAOYAE
Std. InChI: InChI=1S/C5H9NO3S/c1-3(10)5(9)6-2-4(7)8/h3,10H,2H2,1H3,(H,6,9)(H,7,8)
Std. InChIKey: YTGJWQPHMWSCST-UHFFFAOYSA-N
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mammal (species unspecified) | LD50 | unreported | 2100mg/kg (2100mg/kg) | Indian Journal of Experimental Biology. Vol. 19, Pg. 396, 1981. | |
mouse | LD50 | intraperitoneal | 673mg/kg (673mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 1138, 1969. | |
mouse | LD50 | intravenous | 1733mg/kg (1733mg/kg) | Japanese Journal of Antibiotics. Vol. 38, Pg. 137, 1985. | |
mouse | LD50 | oral | 2330mg/kg (2330mg/kg) | Drugs in Japan Vol. 6, Pg. 456, 1982. | |
mouse | LD50 | subcutaneous | 2290mg/kg (2290mg/kg) | Japanese Journal of Antibiotics. Vol. 41, Pg. 105, 1988. | |
rabbit | LD50 | intravenous | 1800mg/kg (1800mg/kg) | BEHAVIORAL: EXCITEMENT | "Proceedings of the International Symposium on Thiola, Tokyo, Japan, 1970," Osaka, Japan, Santen Pharmaceutical Co., Ltd., 1970Vol. -, Pg. 9, 1970. |
rat | LD50 | intramuscular | 1630mg/kg (1630mg/kg) | United States Patent Document. Vol. #4242354, | |
rat | LD50 | intraperitoneal | 1400mg/kg (1400mg/kg) | Farmaco, Edizione Scientifica. Vol. 41, Pg. 758, 1986. | |
rat | LD50 | oral | 1300mg/kg (1300mg/kg) | Drugs in Japan Vol. 6, Pg. 456, 1982. | |
women | TDLo | oral | 3120mg/kg/26W (3120mg/kg) | BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" | American Journal of Kidney Diseases. Vol. 19, Pg. 179, 1992. |
Safety Information about Meprin (CAS NO.1953-02-2):
Hazard Codes: Xn
Risk Statements: 22
R22: Harmful if swallowed.
Safety Statements: 36/37
S36/37: Wear suitable protective clothing and gloves.
WGK Germany: 3
RTECS: MC0596500
Moderately toxic by ingestion, intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx. See also MERCAPTANS.