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22551-24-2

Basic Information
CAS No.: 22551-24-2
Name: A-(METHYLTHIO)ACETAMIDE
Article Data: 8
Molecular Structure:
Molecular Structure of 22551-24-2 (A-(METHYLTHIO)ACETAMIDE)
Formula: C3H7NOS
Molecular Weight: 105.161
Synonyms: (Methylthio)acetamide;
Density: 1.132 g/cm3
Melting Point: 99-102 °C
Boiling Point: 258.8 °C at 760 mmHg
Flash Point: 110.3 °C
Appearance: white solid
PSA: 68.39000
LogP: 0.53500
Synthetic route
35928-65-5

(methylthio)acetyl chloride

22551-24-2

2-(methylthio)acetamide

Conditions
ConditionsYield
With ammonia In diethyl ether at 0℃;97%
With ammonia In benzene for 0.0833333h;
16630-66-3

methyl 2-(methylthio)acetate

22551-24-2

2-(methylthio)acetamide

Conditions
ConditionsYield
With ammonium hydroxide at 20 - 25℃; for 2.25h;76.2%
4455-13-4

methylthioacetic acid ethyl ester

22551-24-2

2-(methylthio)acetamide

Conditions
ConditionsYield
With ammonia
79-07-2

Chloroacetamide

5188-07-8

sodium thiomethoxide

22551-24-2

2-(methylthio)acetamide

Conditions
ConditionsYield
With ethanol
35120-10-6

methylthioacetonitrile

A

22551-24-2

2-(methylthio)acetamide

B

2444-37-3

methylsulfanyl-acetic acid

Conditions
ConditionsYield
With potassium phosphate buffer; lyophilized Zea mays nitrilase ZmNIT2 EC 3.5.5.1 In water at 30℃; for 14h; pH=7.15; Title compound not separated from byproducts;
96-34-4

methyl chloroacetate

5188-07-8

sodium thiomethoxide

22551-24-2

2-(methylthio)acetamide

Conditions
ConditionsYield
Stage #1: methyl chloroacetate; sodium thiomethoxide With tetramethylammonium bromide at 20 - 50℃; for 1h;
Stage #2: With ammonium hydroxide at 0 - 5℃;
55.85 g
22551-24-2

2-(methylthio)acetamide

343269-10-3

3-Methyl-2-methylsulfanyl-pent-4-enoic acid amide

Conditions
ConditionsYield
With potassium carbonate for 48h;95%
22551-24-2

2-(methylthio)acetamide

37677-17-1

1-bromomethylcyclohexene

72730-26-8

2-(2-Methylene-cyclohexyl)-2-methylsulfanyl-acetamide

Conditions
ConditionsYield
With potassium carbonate for 48h;92%
22551-24-2

2-(methylthio)acetamide

81442-38-8

α-(Methylsulfinyl)-acetamide

Conditions
ConditionsYield
With NaJO4 In methanol; water Ambient temperature; overnight;90%
With dihydrogen peroxide; acetone
22551-24-2

2-(methylthio)acetamide

2835-77-0

(2-aminophenyl)(phenyl)methanone

78281-61-5

2-amino-3-benzoyl-α-(methylthio)benzeneacetamide

Conditions
ConditionsYield
Stage #1: 2-(methylthio)acetamide; (2-aminophenyl)(phenyl)methanone With N-chloro-succinimide In dichloromethane at -45 - 8℃;
Stage #2: With triethylamine In dichloromethane Product distribution / selectivity;
86.4%
Stage #1: (2-aminophenyl)(phenyl)methanone With N-chloro-succinimide In dichloromethane at -35 - -25℃; for 0.5h;
Stage #2: 2-(methylthio)acetamide In dichloromethane at 0 - 10℃; for 2h; Solvent;
80.27%
Stage #1: 2-(methylthio)acetamide; (2-aminophenyl)(phenyl)methanone With N-chlorophthalimide In dichloromethane at -20 - -5℃; for 3.5h;
Stage #2: With triethylamine In dichloromethane
Stage #3: With potassium hydroxide In dichloromethane; water Temperature; Concentration;
63.1%
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  • A-(METHYLTHIO)ACETAMIDE

  • Casno:

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  • 2-(Methylthio)acetamide cas  22551-24-2

  • Casno:

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  • Casno:

    22551-24-2

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  • 2-(Methylthio)acetamide

  • Casno:

    22551-24-2

    2-(Methylthio)acetamide

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  • 2-(Methylthio)acetamide

  • Casno:

    22551-24-2

    2-(Methylthio)acetamide

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Specification

The 2-(Methylthio)acetamide ,its cas register number is 22551-24-2.It also can be called as Acetamide,2-(methylthio)- and the Systematic name about this chemicals is 2-(Methylsulfanyl)acetamide .It is a white solid and can be used as Pharmaceutical Intermediates.If you want to sotre this chemicals, please keep containers tightly sealed, and store in cool, dry place in tighely closed containers.

Following are the chemical properties about 2-(Methylthio)acetamide : (1)#H bond acceptors: 2 ; (2)#H bond donors: 2 ; (3)#Freely Rotating Bonds: 2 ; (4)Polar Surface Area: 45.61 Å ; (5)Index of Refraction: 1.504 ; (6)Molar Refractivity: 27.5 cm3 ; (7)Molar Volume: 92.8 cm3 ; (8)Surface Tension: 41.9 dyne/cm; (9)Enthalpy of Vaporization: 49.64 kJ/mol ; (10)Vapour Pressure: 0.0135 mmHg at 25°C .

This chemicals can be described computed from structure:
(1)SMILES: O=C(N)CSC
(2)InChI: InChI=1/C3H7NOS/c1-6-2-3(4)5/h2H2,1H3,(H2,4,5)
(3)InChIKey: OBENGAMZEGRSIC-UHFFFAOYAN