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CAS No.: | 2373-98-0 |
---|---|
Name: | 3,3'-Dihydroxybenzidine |
Molecular Structure: | |
Formula: | C12H12 N2 O2 |
Molecular Weight: | 216.239 |
Synonyms: | 3,3'-Biphenyldiol,4,4'-diamino- (8CI);m,m'-Biphenol, 6,6'-diamino- (7CI);3,3'-Dihydroxy-4,4'-diaminobiphenyl;3,3'-Dihydroxybenzidine;HAB (diol);[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dihydroxy-; |
EINECS: | 679-800-2 |
Density: | 1.384g/cm3 |
Melting Point: | 292 °C |
Boiling Point: | 440.7°Cat760mmHg |
Flash Point: | 220.3°C |
Solubility: | Practically insoluble in water |
Hazard Symbols: | T |
Risk Codes: | 40-45-48-36/37/38 |
Safety: | Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. |
PSA: | 92.50000 |
LogP: | 3.09160 |
3,3'-dihydroxybenzidine
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In tetrahydrofuran for 2h; Cooling with ice; | 97.4% |
3,3'-dihydroxybenzidine
Conditions | Yield |
---|---|
Stage #1: C14H8N2O4 With ammonium hydroxide at 100 - 110℃; under 750.075 - 2250.23 Torr; Large scale; Stage #2: With sulfuric acid at 20 - 70℃; pH=3-4; Large scale; | 89.9% |
Conditions | Yield |
---|---|
With hydrogen iodide at 138℃; | |
With potassium hydroxide at 230 - 240℃; under 22065.2 - 29420.3 Torr; |
3,3'-dimethoxy-(1,1'-biphenyl)-4,4'-diamine
A
3,3'-dihydroxybenzidine
B
4,4'-diamino-3'-methoxy-biphenyl-3-ol
Conditions | Yield |
---|---|
With sulfuric acid |
Conditions | Yield |
---|---|
With sodium hydroxide at 230 - 240℃; under 22065.2 - 29420.3 Torr; |
3,3'-bis-sulfooxy-benzidine
3,3'-dihydroxybenzidine
Conditions | Yield |
---|---|
With hydrogenchloride | |
With hydrogenchloride | |
With sulfuric acid |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: triethylamine / 1,2-dichloro-ethane / 65 - 75 °C / Large scale 2.1: hydrogen; platinum on activated charcoal / 1,2-dichloro-ethane / 55 - 65 °C / 4500.45 - 6000.6 Torr / Large scale 3.1: sulfuric acid; sodium nitrite; copper(II) sulfate / isopropyl alcohol; ethyl acetate / Heating; Large scale 4.1: sulfuric acid; sodium iodide; dihydrogen peroxide / methanol / 34 - 38 °C / Large scale 5.1: palladium on activated charcoal; triethylamine / toluene / Heating; Large scale 6.1: ammonium hydroxide / 100 - 110 °C / 750.08 - 2250.23 Torr / Large scale 6.2: 20 - 70 °C / pH 3-4 / Large scale View Scheme |
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3,3'-Dihydroxybenzidine(2373-98-0) is also named as 3,3-Dihydroxy-4,4-diamino-biphenyl; 3,3'-Dihydroxybenzidine(p-HAB);1’-biphenyl)-3,3’-diol,4,4'-diamino-(;1’-biphenyl)-4,4'-diamine,3,3'-dihydroxy-(;3,3'-dihydroxy-benzidin;3,3'-dioxybenzidine;3,3'-dwuoksybenzydyna;3,3'-dwuoksybenzydyna(polish);4,4'-diamino-3'-biphenyldiol;6,6'-diamino-m'-biphenol,and so on.
CAS: 2373-98-0
Molecular Formula: C12H12N2O2
Molecular Weight: 216.24
Molecular structure:
Melting point: 292 °C
Index of Refraction: 1.741
Molar Refractivity: 63.08 cm3
Molar Volume: 156.1 cm3
Polarizability: 25 10-24cm3
Surface Tension: 76.8 dyne/cm
Density: 1.384 g/cm3
Flash Point: 220.3 °C
Enthalpy of Vaporization: 72.47 kJ/mol
Boiling Point: 440.7 °C at 760 mmHg
Vapour Pressure: 2.24E-08 mmHg at 25°C
3,3'-Dihydroxybenzidine(2373-98-0) is commonly used as pharmaceutical intermediates.
1. | pic-esc 100 mmol/L | MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. 31 (1979),11. | ||
2. | orl-rat TDLo:9950 mg/kg/52W-I:NEO | VOONAW Voprosy Onkologii. Problems of Onkology. 7 (2)(1961),33. | ||
3. | orl-mus TDLo:11 g/kg/47W-I:ETA | VOONAW Voprosy Onkologii. Problems of Onkology. 7 (2)(1961),33. |
RTECS: DV4900000
3,3'-Dihydroxybenzidine(2373-98-0) is suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Risk Statements: 40
Safety Statements: 22-53
Hazardous Substances Data: 2373-98-0(Hazardous Substances Data)