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| CAS No.: | 2524-03-0 |
|---|---|
| Name: | Dimethyl chlorothiophosphate |
| Article Data: | 35 |
| Molecular Structure: | |
|
|
|
| Formula: | C2H6ClO2PS |
| Molecular Weight: | 160.561 |
| Synonyms: | Methylphosphorochloridothioate ((MeO)2ClPS) (6CI,7CI);Chlorodimethoxyphosphinesulfide;Dimethoxy thiophosphonyl chloride;Dimethyl chlorophosphorothioate;Dimethyl chlorothionophosphate;Dimethyl chlorothiophosphate;Dimethylthionophosphorochloridate;Dimethyl thiophosphorochloridate;NSC 132984;O,O-Dimethyl chlorophosphorothioate;O,O-Dimethyl chlorothionophosphate;O,O-Dimethyl chlorothiophosphate;O,O-Dimethyl phosphorochloridothioate; |
| EINECS: | 219-754-9 |
| Density: | 1.364 g/cm3 |
| Boiling Point: | 175.784 °C at 760 mmHg |
| Flash Point: | 105 °C |
| Solubility: | slowly hydrolyzes with water |
| Appearance: | clear colorless to light yellow liquid |
| Hazard Symbols: |
 T
|
| Risk Codes: | 23/24/25-34-23-21/22 |
| Safety: | 23-26-36/37/39-45-24/25 |
| Transport Information: | UN 2267 6.1/PG 2 |
| PSA: | 60.36000 |
| LogP: | 2.39310 |
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| Conditions | Yield |
|---|---|
| With chlorine at 20 - 740℃; Reagent/catalyst; Temperature; | 98.6% |
| Conditions | Yield |
|---|---|
| With chlorine; iron In water at 50℃; for 6h; | 94.3% |
| With chlorine at 30 - 40℃; for 3h; Temperature; Green chemistry; | 92.1% |
| With chlorine; benzene | |
| With chlorine In tetrachloromethane at 0℃; Inert atmosphere; | |
| With chlorine; benzene |
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 0 - 5℃; for 1h; | 93% |
| Conditions | Yield |
|---|---|
| With sodium hydroxide In dichloromethane; water at -5 - 5℃; for 1h; Inert atmosphere; | 88% |
| Conditions | Yield |
|---|---|
| With sulfuryl dichloride In benzene for 0.5h; | 45% |
| Conditions | Yield |
|---|---|
| With phosphorous (V) sulfide; benzene und anschliessendes Behandeln mit Chlor; | |
| With trichlorothiophosphine; sodium hydroxide at -10℃; |
| Conditions | Yield |
|---|---|
| With phosphorus pentachloride |
| Conditions | Yield |
|---|---|
| With dichloromethane Irradiation; |
- 67-56-1
methanol
A
- 2523-94-6
methyl phosphorodichloridothionate
B
- 152-18-1
O,O,O-trimethylthiophosphate
C
- 2524-03-0
dimethyl chlorothiophosphate
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 20℃; Product distribution; multistep reaction; varying of molar ratio of components; time taken in the addition of alcohol; consumption time of reactants; alcoholysis of PSCl3 (estimation of rel. rates); |
| Conditions | Yield |
|---|---|
| With trichlorothiophosphine In methanol; benzene for 3h; Ambient temperature; |
- Total:2 Page 1 of 1 1
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Chemistry
MF: C2H6ClO2PS
MW: 160.56g/mol
Density: 1.364 g/cm3
Flash Point: 221 °F
Index of Refraction: 1.486
Density: 1.322 g/mL at 25 °C(lit.)
Vapor pressure: 0.67 psi ( 20 °C)
Enthalpy of Vaporization: 39.52 kJ/mol
Refractive index: n20/D 1.482(lit.)
Water Solubility: slowly hydrolyzes
Boiling Point: 175.8 °C at 760 mmHg
Vapour Pressure: 1.52 mmHg at 25°C
Appearance: Colorless to light amber liquid
IUPAC Name: Chloro-dimethoxy-sulfanylidene-$l^{5}-phosphane
Synonyms: AURORA KA-1651 ; Dimethylthiophosphoril chloride ; Dimethylthiophosphoryl chloride ; Dimethyl chlorothiophosphate ; Dimethyl phosphorochloridothionate ; Dimethylphosphorochlorothioate ; Dmpct
Following is the molecular structure of O,O-Dimethylphosphorochlorothioate (2524-03-0):
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Uses
O,O-Dimethylphosphorochlorothioate (2524-03-0) is used as a chemical intermediate for insecticides, pesticides, and fungicides; oil and gasoline additives; plasticizers; corrosion inhibitors; flame retardants; and flotation agents.
Production
Reactivity Profile of O,O-Dimethylphosphorochlorothioate (2524-03-0): Organothiophosphates, such as Dimethyl chlorothiophosphate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Toxicity Data With Reference
| 1. | orl-rat LDLo:1000 mg/kg | 34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,393. | ||
| 2. | ihl-rat LC50:340 mg/m3/4H | 85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,56. | ||
| 3. | orl-mus LD50:1800 mg/kg | 85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,56. | ||
| 4. | ihl-mus LC50:320 mg/m3/2 | 85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,56. | ||
| 5. | skn-rbt LDLo:750 mg/kg | 34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,393. |
Consensus Reports
Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List.
Safety Profile
Poison by inhalation. Moderately toxic by ingestion and skin contact. Corrosive. When heated to decomposition it emits very toxic fumes of Cl−, POx, and SOx.
Safety Information of O,O-Dimethylphosphorochlorothioate (2524-03-0):
Hazard Codes: T
T: Toxic.gif)
Risk Statements: 23/24/25-34-23-21/22
23/24/25: Toxic by inhalation, in contact with skin and if swallowed
34: Causes burns
23: Toxic by inhalation
21/22: Harmful in contact with skin and if swallowed
Safety Statements: 23-26-36/37/39-45-24/25
23: Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
24/25: Avoid contact with skin and eyes
RIDADR: UN 2267 6.1/PG 2
WGK Germany: 3
RTECS: TD1830000
HazardClass: 6.1(a)
PackingGroup: II
Specification
Health Hazard: Dimethyl chlorothiophosphate is a strong irritant to the eyes, skin, and mucous membranes.
Fire Hazard: Dimethyl chlorothiophosphate may burn but does not ignite readily. Dimethyl chlorothiophosphate may ignite combustibles (wood, paper, oil, etc.). When heated Dimethyl chlorothiophosphate emits very toxic fumes of chlorine containing compounds, phosphorus oxides, and sulfur oxides.