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CAS No.: | 2842-44-6 |
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Name: | N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE |
Article Data: | 11 |
Molecular Structure: | |
Formula: | C10H15 N O |
Molecular Weight: | 165.235 |
Synonyms: | Ethanol,2-(N-methyl-p-toluidino)- (7CI,8CI); 2-(N-Methyl-N-4-tolylamino)ethanol;FirstCure MHPT; N-(2-Hydroxyethyl)-N-methyl-p-toluidine;N-Methyl-N-(2-hydroxyethyl)-p-toluidine |
Density: | 1.047g/cm3 |
Boiling Point: | 298.1°Cat760mmHg |
Flash Point: | 148.8°C |
PSA: | 23.47000 |
LogP: | 1.42350 |
Conditions | Yield |
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With N-methyl-1-(thiophen-2-yl)methanamine; tris(triphenylphosphine)ruthenium(II) chloride; 1,1'-bis(dicyclohexylphosphinocyclopentadienyl)iron; potassium tert-butylate In 1,4-dioxane at 150℃; for 20h; | 91% |
(2-hydroxyethyl)(methyl)amine
4-tolyl iodide
2-(methyl(p-tolyl)amino)ethan-1-ol
Conditions | Yield |
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With copper(l) iodide; sodium hydroxide In water; dimethyl sulfoxide at 90℃; for 16h; Buchwald-Hartwig Coupling; Sealed tube; Inert atmosphere; | 82% |
D-Xylose
N-methyl-p-toluidine
2-(methyl(p-tolyl)amino)ethan-1-ol
Conditions | Yield |
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With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 150℃; for 16h; Inert atmosphere; Glovebox; chemoselective reaction; | 75% |
2-(methyl(p-tolyl)amino)ethan-1-ol
Conditions | Yield |
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With potassium carbonate |
N-(4-methylphenyl)-N-methylglycine ethyl ester
2-(methyl(p-tolyl)amino)ethan-1-ol
Conditions | Yield |
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With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; Inert atmosphere; |
Conditions | Yield |
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With disodium hydrogenphosphate; citric acid In dimethyl sulfoxide at 37℃; Kinetics; pH-value; |
2-(methyl(p-tolyl)amino)ethan-1-ol
Conditions | Yield |
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With 1H-imidazole; iodine; triphenylphosphine In toluene at 100℃; for 28h; Inert atmosphere; | 79% |
2-(methyl(p-tolyl)amino)ethan-1-ol
benzyl bromide
N-(2-(benzyloxy)ethyl)-N-methyl-p-toluidine
Conditions | Yield |
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Stage #1: 2-(methyl(p-tolyl)amino)ethan-1-ol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: benzyl bromide In tetrahydrofuran; mineral oil at 0 - 20℃; Inert atmosphere; |
2-(methyl(p-tolyl)amino)ethan-1-ol
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: 1H-imidazole; triphenylphosphine; iodine / toluene / 28 h / 100 °C / Inert atmosphere 2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.08 h / 0 - 20 °C / Inert atmosphere 2.2: 18 h / 80 °C / Inert atmosphere View Scheme |
2-(methyl(p-tolyl)amino)ethan-1-ol
Conditions | Yield |
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Multi-step reaction with 3 steps 1.1: 1H-imidazole; triphenylphosphine; iodine / toluene / 28 h / 100 °C / Inert atmosphere 2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.08 h / 0 - 20 °C / Inert atmosphere 2.2: 18 h / 80 °C / Inert atmosphere 3.1: copper(II) 2-ethylhexanoate; N-ethyl-N,N-diisopropylamine / toluene / 19 h / 120 °C View Scheme |