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| CAS No.: | 305-72-6 |
|---|---|
| Name: | Disodium 2-oxoglutarate dihydrate |
| Molecular Structure: | |
|
|
|
| Formula: | C5H4Na2O5 |
| Molecular Weight: | 190.063 |
| Synonyms: | Glutaricacid, 2-oxo-, disodium salt (8CI);Pentanedioic acid, 2-oxo-, disodium salt(9CI);2-Oxoglutaric acid disodium salt;Disodium 2-oxoglutarate;Disodium2-oxopentanedioate;Disodium a-ketoglutarate;a-Oxoglutaric acid disodium salt;Disodium 2-oxoglutarate;Pentanedioic acid, 2-oxo-, disodium salt;α-Ketoglutaric acid disodium salt; |
| EINECS: | 206-167-8 |
| Density: | 1.499g/cm3 |
| Boiling Point: | 345.6 °C at 760 mmHg |
| Flash Point: | 177 °C |
| Solubility: | soluble |
| Appearance: | White powder. |
| Hazard Symbols: | T |
| Risk Codes: | 23/24/25-36/37/38 |
| Safety: | 22-24/25-45-36/37/39-26 |
| PSA: | 115.79000 |
| LogP: | -3.29310 |
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2-oxoglutaric acid 1-ethyl ester
- 305-72-6
α-ketoglutaric acid disodium salt
| Conditions | Yield |
|---|---|
| With [D]-sodium hydroxide; water-d2 for 0.00416667h; pH=11; | >= 95 %Spectr. |
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water at 25 - 35℃; Reagent/catalyst; Large scale; |
- 305-72-6
α-ketoglutaric acid disodium salt
| Conditions | Yield |
|---|---|
| With water-d2 at 80℃; for 3h; Substitution; | 100% |
- 305-72-6
α-ketoglutaric acid disodium salt
- 71686-01-6
calcium alpha-ketaglutarate
| Conditions | Yield |
|---|---|
| With calcium chloride In water at 65 - 70℃; Large scale; | 77% |
| Conditions | Yield |
|---|---|
| In dichloromethane; water at 20℃; | 75% |
| In dichloromethane; water |
| Conditions | Yield |
|---|---|
| In water at 80 - 85℃; Large scale; | 73% |
- 932-98-9
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- 305-72-6
α-ketoglutaric acid disodium salt
A
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B
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C
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2-amino-5-chlorophenol
D
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N-(4-chloro-2-hydroxyphenyl)succinamic acid
| Conditions | Yield |
|---|---|
| With thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride In water at 30℃; for 2h; 0.05M KH2PO4 buffer (pH 7.5); Further byproducts given. Yields of byproduct given; | A n/a B n/a C n/a D 2 mg |
- 932-98-9
1-chloro-4-nitroso-benzene
- 305-72-6
α-ketoglutaric acid disodium salt
A
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4-(4'-hydroxy-phenylamino)-4-oxo-butanoic acid
B
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2-amino-5-chlorophenol
C
- 81576-12-7
N-(4-chlorophenyl)succinohydroxamic acid
D
- 81576-13-8
N-(4-chloro-2-hydroxyphenyl)succinamic acid
| Conditions | Yield |
|---|---|
| With thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride In water at 30℃; for 2h; 0.05M KH2PO4 buffer (pH 7.5); Further byproducts given. Yields of byproduct given; | A n/a B n/a C 1.5 mg D 2 mg |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium tetrahydroborate for 0.0833333h; Reduction; |
- 305-72-6
α-ketoglutaric acid disodium salt
| Conditions | Yield |
|---|---|
| With isocitrate dehydrogenase; water-d2; NADPH at 37℃; for 2h; Substitution; |
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Chemistry
Name:α-ketoglutaric acid,disodium salt(305-72-6)
Molecular Formula:C5H4O5.2Na
Molecular Weight: 190.06g/mol
EINECS: 206-167-8
Chemical Properties: white powder
Density: 1.499g/cm3
Boiling Point: 345.6°C at 760 mmHg
Flash Point: 177 °C
Solubility: soluble in water
Freely Rotating Bonds: 4
Polarizability: 10-24cm3
Enthalpy of Vaporization: 64.8 kJ/mol
Vapour Pressure: 1.08E-05 mmHg at 25°C
The chemical synonyms of α-ketoglutaric acid,disodium salt(305-72-6) are 2-oxo-pentanedioicacidisodiumsalt;DISODIUM 2-KETOGLUTARATE;DISODIUM 2-OXOGLUTARATE;ALPHA-KETOGLUTARIC ACID, SESQUISODIUM SALT;ALPHA-KETOGLUTARATE DISODIUM;ALPHA-KETOGLUTARIC ACID DISODIUM SALT;2-KETOGLUTARIC ACID DISODIUM SALT;2-KETOGLUTARIC ACID SODIUM SALT .The molecular structure of α-ketoglutaric acid,disodium salt(305-72-6) is
.
Uses
α-ketoglutaric acid,disodium salt(305-72-6) is used as pharmaceutical intermediate.
Toxicity Data With Reference
| 1. | orl-rat LD50:7.1 g/kg | JAPTO* Journal of Applied Toxicology 21 (2001),495. | ||
| 2. | orl-rat TDLo:2 g/kg | JAPTO* Journal of Applied Toxicology 21 (2001),495. | ||
| 3. | orl-rat TDLo:4 g/kg | JAPTO* Journal of Applied Toxicology 21 (2001),495. |
Safety Profile
Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.
Hazard Codes: 
T
T: Toxic
Risk Statements: 23/24/25-36/37/38
23/24/25: Toxic by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25-45-36/37/39-26
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
24/25: Avoid contact with skin and eyes
36/37/39: Wear suitable protective clothing, gloves and eye/face protection