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CAS No.: | 3647-69-6 |
---|---|
Name: | 4-(2-Chloroethyl)morpholine hydrochloride |
Article Data: | 5 |
Molecular Structure: | |
Formula: | C6H12ClNO.HCl |
Molecular Weight: | 186.081 |
Synonyms: | Morpholine,4-(2-chloroethyl)-, hydrochloride (6CI,7CI,8CI,9CI);1-(Morpholin-4-yl)-2-chloroethane hydrochloride;1-Chloro-2-morpholinoethanehydrochloride;2-(4-Morpholinyl)ethyl chloride hydrochloride;2-Morpholinoethylchloride hydrochloride;4-(2-Chloroethyl)morpholine monohydrochloride;4-(2-Chloroethyl)morpholiniumchloride;Morpholinoethyl chloride hydrochloride;N-(2-Chloroethyl)morpholinehydrochloride;N-(b-Chloroethyl)morpholine hydrochloride;b-Morpholinoethyl chloride hydrochloride; |
EINECS: | 222-881-2 |
Density: | 1.088g/cm3 |
Melting Point: | 180-185 °C (dec.)(lit.) |
Boiling Point: | 202.8 °C at 760 mmHg |
Flash Point: | 76.4 °C |
Solubility: | Soluble in water |
Appearance: | White to beige crystalline powder |
Hazard Symbols: | T |
Risk Codes: | 21-25-34-43-52/53 |
Safety: | 26-36/37/39-45-61 |
Transport Information: | UN 2923 8/PG 3 |
PSA: | 12.47000 |
LogP: | 1.29730 |
B
4-(2-chloroethyl)morpholine hydrochride
B
4-(2-chloroethyl)morpholine hydrochride
B
4-(2-chloroethyl)morpholine hydrochride
Conditions | Yield |
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With thionyl chloride; sodium hydroxide In toluene for 5h; Reflux; | |
Stage #1: morpholine; 2-chloro-ethanol In toluene for 2h; Reflux; Stage #2: With thionyl chloride In toluene at 20℃; for 6.33h; Cooling with ice; | 7.9 g |
Conditions | Yield |
---|---|
With thionyl chloride In chloroform Reflux; Cooling with ice; |
4-(2-chloroethyl)morpholine hydrochride
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 18h; | 100% |
4-(2-chloroethyl)morpholine hydrochride
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 18h; | 100% |
methyl 3-hydroxy-2-methylbenzoate
4-(2-chloroethyl)morpholine hydrochride
methyl 2-methyl-3-(2-morpholinoethoxy)benzoate
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile Heating; | 100% |
4-(2-chloroethyl)morpholine hydrochride
methyl 4-hydroxylbenzoate
methyl 4-(2-morpholinoethoxy)benzoate
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 50℃; | 100% |
With caesium carbonate In acetonitrile at 80 - 85℃; for 4h; Inert atmosphere; | 92% |
With potassium carbonate In acetone Heating; |
4-hydroxy-2-nitroanisole
4-(2-chloroethyl)morpholine hydrochride
4-[2-(4-methoxy-3-nitro-phenoxy)-ethyl]-morpholine
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In DMF (N,N-dimethyl-formamide) at 80℃; for 4h; | 100% |
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Molecular Formula: C6H13Cl2NO
Formula Weight: 186.08
mp OF 4-(2-CHLOROETHYL)MORPHOLINE HYDRO CHLORIDE (3647-69-6): 180-185 °C (dec.)(lit.)
Flash Point: 76.4 °C
Boiling Point: 202.8 °C at 760 mmHg
Water Solubility : soluble
Vapour Pressure: 0.288 mmHg at 25°C
Sensitive of 4-(2-CHLOROETHYL)MORPHOLINE HYDRO CHLORIDE (3647-69-6): Hygroscopic
Appearence of 4-(2-CHLOROETHYL)MORPHOLINE HYDRO CHLORIDE (3647-69-6): White to beige crystalline powder
4-(2-Chloroethyl)morpholine hydro chloride (3647-69-6) (MOC) is used as intermediate for the synthesis of pharmaceuticals (e.g. floredil, morinamide, nimorazole and pholcodine).
4-(2-Chloroethyl)morpholine hydro chloride (3647-69-6) is obtained by thionyl chloride chlorination reaction with morpholine ethanol, which is get from the addition reaction of morpholine and epoxy ethane.
1. | mmo-sat 21,500 nmol/L | ENMUDM Environmental Mutagenesis. 3 (1981),11. | ||
2. | mmo-esc 21,500 nmol/L | ENMUDM Environmental Mutagenesis. 3 (1981),11. | ||
3. | dns-rat:lvr 100 µmol/L | ENMUDM Environmental Mutagenesis. 3 (1981),11. | ||
4. | msc-mus:lym 44 µmol/L | ENMUDM Environmental Mutagenesis. 3 (1981),33. |
Safety: WARNING: Irreversible damage risk, protect skin/eyes/lungs.
Hazard Codes : T (Toxic)
Risk Statements : 21-25-34-43-52/53 (Harmful in contact with skin; Toxic if swallowed; Causes burns; May cause sensitization by skin contact; Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment)
Safety Statements : 26-36/37/39-45-61 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing, gloves and eye/face protection; In case of accident or if you feel unwell, seek medical advice immediately; Avoid release to the environment. Refer to special instructions safety data sheet)
RIDADR : UN 2923 8/PG 3
WGK Germany : 2
RTECS : QE0260000
PackingGroup : III
HS Code : 29349990
Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep container closed when not in use.