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| CAS No.: | 369-34-6 |
|---|---|
| Name: | 3,4-Difluoronitrobenzene |
| Molecular Structure: | |
|
|
|
| Formula: | C6H3F2NO2 |
| Molecular Weight: | 159.092 |
| Synonyms: | Benzene, 1,2-difluoro-4-nitro-;1,2-Difluoro-4-nitrobenzene;3,4-Difluoro nitrobenzene;3,4-Difluoro-1-Nitrobenzene;2,4-Difluoro Nitrobenzene; |
| EINECS: | 206-718-2 |
| Density: | 1.45 g/cm3 |
| Melting Point: | -12 °C |
| Boiling Point: | 200 °C at 760 mmHg |
| Flash Point: | 80.6 °C |
| Solubility: | insoluble in water |
| Appearance: | clear yellow liquid |
| Hazard Symbols: |
 Xi, Xn
|
| Risk Codes: | 36/37/38-20/21/22 |
| Safety: | 26-36/37/39 |
| PSA: | 45.82000 |
| LogP: | 2.39620 |
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| Conditions | Yield |
|---|---|
| With molecular sieve; nitric acid; acetic anhydride at 0℃; for 3h; other reagent: nitric acid/sulfuric acid; | 98% |
| With sulfuric acid; nitric acid at 20℃; for 0.0180556h; Temperature; | 97.3% |
| With sulfuric acid; nitric acid at 60 - 70℃; for 6h; | 91% |
- 20372-63-8
4,5-difluoro-2-nitrobenzoic acid
- 369-34-6
3,4-difluoronitrobenzene
| Conditions | Yield |
|---|---|
| With copper In 1-methyl-pyrrolidin-2-one at 250℃; for 0.5h; | 94% |
- 99-54-7
3,4-dichloronitrobenzene
A
- 369-34-6
3,4-difluoronitrobenzene
B
- 350-30-1
3-chloro-4-fluoronitrobenzene
| Conditions | Yield |
|---|---|
| With potassium fluoride; tetraphenylphosphonium bromide at 175 - 195℃; for 30h; Yields of byproduct given; | A n/a B 79% |
| With potassium fluoride; 2-(4-chlorophenyl)propene copolymer-grafted tetraphenylphosphonium chloride; cross-linked styrene In sulfolane at 210℃; for 7h; | A 12% B 64% |
| With potassium fluoride; tetraphenylphosphonium bromide at 175 - 195℃; for 30h; Yield given. Yields of byproduct given; |
| Conditions | Yield |
|---|---|
| With potassium fluoride; 3,4,5,6-tetrafluorophthaloyldifluoride In sulfolane at 200℃; for 13h; | 77% |
| Conditions | Yield |
|---|---|
| With potassium fluoride; benzene-1,2,4,5-tetracarbonyl chloride In sulfolane at 200℃; for 4h; | 58% |
| Conditions | Yield |
|---|---|
| With formic acid; fluorine at 10℃; for 1.75h; Fluorination; | 53% |
- 97-00-7
1-chloro-2,4-dinitro-benzene
A
- 369-34-6
3,4-difluoronitrobenzene
B
- 364-74-9
1,4-difluoro-2-nitrobenzene
| Conditions | Yield |
|---|---|
| With potassium fluoride; tetraphenylphosphonium bromide; Phthaloyl dichloride In sulfolane; toluene at 190℃; for 6h; | A 46% B 3 % Chromat. |
| With potassium fluoride; Phthaloyl dichloride; tetraphenylphosphonium bromide In sulfolane 1) 150 deg C, 2 h, 2) 190 deg C, 6 h; | A 46% B 3% |
- 70-34-8
2,4-Dinitrofluorobenzene
A
- 369-34-6
3,4-difluoronitrobenzene
B
- 68-12-2, 33513-42-7
N,N-dimethyl-formamide
| Conditions | Yield |
|---|---|
| With potassium fluoride at 145℃; | |
| With potassium fluoride at 155℃; |
- 97-00-7
1-chloro-2,4-dinitro-benzene
A
- 369-34-6
3,4-difluoronitrobenzene
B
- 68-12-2, 33513-42-7
N,N-dimethyl-formamide
| Conditions | Yield |
|---|---|
| With potassium fluoride at 155℃; | |
| With potassium fluoride at 145℃; |
- 115561-03-0
1-fluoro-2-fluorosulfonyl-4-nitrobenzene
A
- 369-34-6
3,4-difluoronitrobenzene
B
- 62094-86-4
2,5-difluorobenzenesulfonyl fluoride
| Conditions | Yield |
|---|---|
| With potassium fluoride; tetraphenylphosphonium bromide In sulfolane; toluene at 210℃; under 300 Torr; Title compound not separated from byproducts; | |
| With potassium fluoride; tetraphenylphosphonium bromide In sulfolane at 210℃; under 270 - 300 Torr; for 5h; Yield given. Yields of byproduct given; |
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Chemistry
IUPAC Name: 1,2-difluoro-4-nitrobenzene
Synonyms of 3,4-Difluoronitrobenzene (CAS NO.369-34-6): 1,2-Difluoro-4-nitrobenzene ; Benzene, 1,2-difluoro-4-nitro-
CAS NO: 369-34-6
Molecular Formula: C6H3F2NO2
Molecular Weight: 159.09
Molecular Structure: 
EINECS: 206-718-2
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 45.82 Å2
Index of Refraction: 1.509
Molar Refractivity: 32.78 cm3
Molar Volume: 109.6 cm3
Surface Tension: 40.6 dyne/cm
Density: 1.45 g/cm3
Flash Point: 80.6 °C
Enthalpy of Vaporization: 41.84 kJ/mol
Boiling Point: 200 °C at 760 mmHg
Vapour Pressure: 0.469 mmHg at 25°C
Melting Point: -12°C
Water Solubility: insoluble
Appearance: clear yellow liquid
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases
Product Categories: HALIDE;Aromatic Halides (substituted);Fluorine Compounds;Nitro Compounds
Uses
3,4-Difluoronitrobenzene (CAS NO.369-34-6) is used as intermediates in medicine, pesticide.
Safety Profile
Safety Information about 3,4-Difluoronitrobenzene (CAS NO.369-34-6)
Hazard Codes: 
Xi,Xn
Risk Statements: 36/37/38-20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 2810
WGK Germany: 3
RTECS: CZ5710000
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
Specification
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Combustible liquid.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container.