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| CAS No.: | 3967-32-6 |
|---|---|
| Name: | 5-(1-Methyl-4-Piperidyl)5H-Dibenzo |
| Article Data: | 7 |
| Molecular Structure: | |
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| Formula: | C21H23 N O |
| Molecular Weight: | 305.42 |
| Synonyms: | 5H-Dibenzo[a,d]cyclohepten-5-ol,5-(1-methyl-4-piperidyl)- (7CI,8CI); 5-(1-Methyl-4-piperidyl)-5H-dibenzo[a,d]cyclohepten-5-ol |
| Density: | 1.158g/cm3 |
| Melting Point: | 166.7-167.7 °C(Solv: benzene (71-43-2); hexane (110-54-3)) |
| Boiling Point: | 467.7°C at 760 mmHg |
| Flash Point: | 132.2°C |
| PSA: | 23.47000 |
| LogP: | 3.68600 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 43224-75-52,2,6,6-Tetramethyl-4-(2-propyleneoxy) Piperidine
- 5570-77-4
4-chloro-1-methylpiperidine
- 2222-33-5
dibenzosuberenon
- 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol
| Conditions | Yield |
|---|---|
| Stage #1: 4-chloro-1-methylpiperidine With iodine; magnesium In tetrahydrofuran for 5h; Reflux; Inert atmosphere; Stage #2: With (trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride In tetrahydrofuran; diethyl ether at 20℃; for 0.75h; Inert atmosphere; Stage #3: dibenzosuberenon In tetrahydrofuran; diethyl ether at 0℃; for 2h; Inert atmosphere; | 99% |
| Stage #1: 4-chloro-1-methylpiperidine With magnesium In tetrahydrofuran at 60 - 65℃; for 1h; Inert atmosphere; Large scale; Stage #2: dibenzosuberenon In tetrahydrofuran at 5 - 20℃; for 1h; Temperature; Inert atmosphere; Large scale; |
- 63463-36-5
(1-methyl-4-piperidyl)magnesium chloride
- 2222-33-5
dibenzosuberenon
- 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol
| Conditions | Yield |
|---|---|
| In tetrahydrofuran at 70℃; | 76% |
| Conditions | Yield |
|---|---|
| With formic acid at 100℃; for 2h; | 99% |
| With hydrogenchloride; acetic acid at 120℃; for 2h; | 83% |
| With formic acid for 1h; Heating; Yield given; |
- 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol
- 3973-59-9
(+/-)-(5H)-1-methyl-4-(5H-dibenzocyclohepten-5-yl)piperidine
| Conditions | Yield |
|---|---|
| With triethylsilane; boron trifluoride In dichloromethane at 0℃; for 3h; | 74% |
- 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol
- 14051-46-8
4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 83 percent / HOAc, conc. HCl / 2 h / 120 °C 2: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux 3: 1) CH3OH, 2) NaOH / 1) r.t., 15 min, 50 deg C, 15 min, 2) water View Scheme |
- 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol
- 175692-31-6
4-(4-Dibenzo[a,d]cyclohepten-5-ylidene-piperidin-1-yl)-butylamine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 83 percent / HOAc, conc. HCl / 2 h / 120 °C 2: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux 3: 1) CH3OH, 2) NaOH / 1) r.t., 15 min, 50 deg C, 15 min, 2) water 4: 80 percent / Na2CO3, KI / acetonitrile; dimethylformamide / Heating 5: 62 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 2 h / Ambient temperature View Scheme |
- 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol
- 141840-85-9
4-<4-(5H-dibenzocyclohepten-5-ylidene)piperidino>butanonitrile
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 83 percent / HOAc, conc. HCl / 2 h / 120 °C 2: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux 3: 1) CH3OH, 2) NaOH / 1) r.t., 15 min, 50 deg C, 15 min, 2) water 4: 80 percent / Na2CO3, KI / acetonitrile; dimethylformamide / Heating View Scheme |
- 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol
- 175692-29-2
7-(4-Dibenzo[a,d]cyclohepten-5-ylidene-piperidin-1-yl)-heptylamine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 83 percent / HOAc, conc. HCl / 2 h / 120 °C 2: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux 3: 1) CH3OH, 2) NaOH / 1) r.t., 15 min, 50 deg C, 15 min, 2) water 4: 99 percent / K2CO3 / acetonitrile / 90 °C 5: 81 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 2 h / Ambient temperature View Scheme |
- 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol
- 175692-23-6
7-(4-Dibenzo[a,d]cyclohepten-5-ylidene-piperidin-1-yl)-heptanenitrile
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 83 percent / HOAc, conc. HCl / 2 h / 120 °C 2: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux 3: 1) CH3OH, 2) NaOH / 1) r.t., 15 min, 50 deg C, 15 min, 2) water 4: 99 percent / K2CO3 / acetonitrile / 90 °C View Scheme |
- 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 83 percent / HOAc, conc. HCl / 2 h / 120 °C 2: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux View Scheme |
