CAS No.41340-25-4,Etodolac Suppliers

Products Categories

Pharmaceutical (184)
Others (41)
Organic Chemicals (36)
Agrochemicals (8)
Reagent (4)
Materials (2)
Plant Extract (1)

Basic Information

Molecular Structure:
CAS No.:	41340-25-4
Name:	Etodolac
Article Data:	11
Cas Database

Formula:	C₁₇H₂₁NO₃
Molecular Weight:	287.359
Synonyms:	(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid;1,3,4,9-Tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid;Prestwick_209;Pyrano(3,4-b)indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-;Lodine;Lodine (TN);Ultradol;{Pyrano[3,} 4-b]indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-;{1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic} acid;Etodolacum [INN-Latin];1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid;Etodolaco [INN-Spanish];Pyrano(3,4-b)indole-1-acetic acid, 1,3,4,9-tetrahydro-1,8-diethyl-;Pyrano[3,4-b]indole-1-acetic acid,1,8-diethyl-1,3,4,9-tetrahydro-;Etodolac (JAN/USP);Etodolic acid;AY 24236;Etodolac Acid;
EINECS:	629-689-1
Density:	1.193 g/cm³
Melting Point:	145-148 °C
Boiling Point:	507.9 °C at 760 mmHg
Flash Point:	260.9 °C
Solubility:	40mg/L(37 oC)
Appearance:	crystalline solid
Hazard Symbols:	T, Xi
Risk Codes:	23/24/25-40-36-25-36/37/38
Safety:	22-36-45-26-36/37
Transport Information:	UN 3249
PSA:	62.32000
LogP:	3.38300

Synthetic route

: 41340-36-7
7-ethyl-2-(1H-indol-3-yl)ethan-1-ol

: 4949-44-4
ethyl propanoylacetate

: 41340-25-4
etodolac

Conditions

Conditions	Yield
(i) TsOH, benzene, (ii) aq. NaOH, EtOH; Multistep reaction;

: 2,2-Dimethyl-propionic acid 2-(1,8-diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetoxymethyl ester

A: 2,2-Dimethyl-propionic acid 2-((S)-1,8-diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetoxymethyl ester

B: 41340-25-4
etodolac

Conditions

Conditions	Yield
With Lipase QL In di-isopropyl ether; water for 192h; Product distribution; Ambient temperature; various lipase enzymes;

: 87226-41-3
(R)-etodolac

: 41340-25-4
etodolac

Conditions

Conditions	Yield
With tin(IV) chloride In tetrahydrofuran; dichloromethane for 4h; Heating / reflux;
sulfuric acid In isopropyl alcohol at 20℃; for 23h; Product distribution / selectivity;

: 87226-41-3
(R)-etodolac

: 87249-11-4
(S)-etodolac

: 41340-25-4
etodolac

Conditions

Conditions	Yield
With tin(IV) chloride In dichloromethane at 20℃; for 2h;
Stage #1: (R)-etodolac; (S)-etodolac In dichloromethane at 20℃; for 2h; Stage #2: With sodium hydroxide; formic acid at 0℃; for 1h; pH=5;

: 87249-11-4
(S)-etodolac

: 41340-25-4
etodolac

Conditions

Conditions	Yield
sulfuric acid In isopropyl alcohol at 20℃; for 4 - 18h; Product distribution / selectivity;
boron trifluoride diethyl etherate In isopropyl alcohol at 20℃; for 15h; Product distribution / selectivity;

: 41340-36-7
7-ethyl-2-(1H-indol-3-yl)ethan-1-ol

: 30414-53-0
methyl propanoyl acetate

: 41340-25-4
etodolac

Conditions

Conditions	Yield
With sulfuric acid In methanol Pictet-Spengler Synthesis;

: 41340-25-4
etodolac

: 200880-25-7
(+/-)-2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)ethanol

Conditions

Conditions	Yield
With LiAlH4 In tetrahydrofuran; hexane; ethyl acetate	98%
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 12h;	92%

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 41340-25-4
etodolac

: Boc-aminopropanol-etodolac

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃; Cooling with ice;	96%

: 528-43-8
Magnolol

: 41340-25-4
etodolac

: 5,5'-diallyl-2'-hydroxy-[1,1'-biphenyl]-2-yl-2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h;	90%
With dmap In dichloromethane at 25 - 30℃;	90%

: 64-19-7
acetic acid

: 41340-25-4
etodolac

: 2-(dimethylamino)ethyl 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetamide acetate

Conditions

Conditions	Yield
Stage #1: N,N-dimethylethylenediamine; etodolac With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In acetonitrile at 20℃; for 3h; Stage #2: acetic acid In ethyl acetate	89.4%

Raw Materials

Total:191 Page 1 of 6 1 2 3 4 5 6 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 41340-25-4

Chemistry

Molecule structure of Etodolac (CAS NO.41340-25-4):

IUPAC Name: 2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
Molecular Weight: 287.35354 g/mol
Molecular Formula: C₁₇H₂₁NO₃
Density: 1.193 g/cm³
Melting Point:145-148 °C
Boiling Point: 507.9 °C at 760 mmHg
Flash Point: 260.9 °C
Index of Refraction: 1.596
Molar Refractivity: 81.98 cm³
Molar Volume: 240.7 cm³
Surface Tension: 53.9 dyne/cm
Enthalpy of Vaporization: 81.93 kJ/mol
Vapour Pressure: 3.88E-11 mmHg at 25 °C
Storage Temp.: 2-8 °C
XLogP3-AA: 2.8
H-Bond Donor: 2
H-Bond Acceptor: 3
Rotatable Bond Count: 4
Exact Mass: 287.152144
MonoIsotopic Mass: 287.152144
Topological Polar Surface Area: 62.3
Heavy Atom Count: 21
Canonical SMILES: CCC1=CC=CC2=C1NC3=C2CCOC3(CC)CC(=O)O
InChI: InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,0-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)
InChIKey: NNYBQONXHNTVIJ-UHFFFAOYSA-N
Product Categories: APIs; Intermediates & Fine Chemicals; Pharmaceuticals

Uses

Etodolac (CAS NO.41340-25-4) is a non-steroidal anti-inflammatory drug (NSAID). It is used to anti-inflammatory.

Production

Etodolac is manufactured by Shire under the trade name Lodine SR and by Meda Pharmaceuticals under the name Eccoxolac . Non-propriety etodolac is also available.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	oral	> 4gm/kg (4000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990.
mouse	LD50	intraperitoneal	338mg/kg (338mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990.
mouse	LD50	oral	593mg/kg (593mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990.
mouse	LD50	subcutaneous	502mg/kg (502mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990.
rat	LD50	intraperitoneal	100mg/kg (100mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990.
rat	LD50	oral	94mg/kg (94mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990.
rat	LD50	subcutaneous	113mg/kg (113mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990.

Safety Profile

Hazard Codes: Toxic T, Irritant Xi
Risk Statements: 23/24/25-40-36-25-36/37/38
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R40: Limited evidence of a carcinogenic effect.
R36: Irritating to eyes.
R25: Toxic if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-36-45-26-36/37
S22: Do not breathe dust.
S36: Wear suitable protective clothing.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
RIDADR: 3249
WGK Germany: 3
RTECS: UQ0360000
HazardClass: 6.1(b)
PackingGroup: III

Specification

Etodolac (CAS NO.41340-25-4) is also named as (+-)-1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid ; 1,3,4,9-Tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid ; 1,8-Diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid ; AY 24236 ; CCRIS 3923 ; Etodolaco ; Etodolaco [INN-Spanish] ; Etodolacum ; Etodolacum [INN-Latin] ; Etodolic acid ; Lodine ; Lodine XL ; NSC 282126 ; Pyrano(3,4-b)indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-(+-)- ; UNII-2M36281008 ; Ultradol . Etodolac (CAS NO.41340-25-4) is crystalline solid. Etodolac belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).

Premium Related Products

Etodolac