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| CAS No.: | 41859-67-0 |
|---|---|
| Name: | Bezafibrate |
| Article Data: | 8 |
| Molecular Structure: | |
|
|
|
| Formula: | C19H20ClNO4 |
| Molecular Weight: | 361.825 |
| Synonyms: | Bezatol SR;LO 44;2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid;Bezalip;Prestwick_724;BF-759;Cedur;2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-propanoic acid;2-{4-[2-(4-chlorobenzamido)ethyl]phenoxy}-2-methylpropanoic acid;BM 15075;Propionic acid, 2-(4-(2-((4-chlorobenzoyl)amino)ethyl)phenoxy)-2-methyl-; |
| EINECS: | 255-567-9 |
| Density: | 1.26 g/cm3 |
| Melting Point: | 184 °C |
| Boiling Point: | 572.1 °C at 760 mmHg |
| Flash Point: | 299.8 °C |
| Solubility: | DMF: soluble |
| Appearance: | Off-white solid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22 |
| Safety: | 36 |
| PSA: | 75.63000 |
| LogP: | 3.94540 |
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2-Ethylhexyl alcohol
- 60-19-5
tyramine hydrochloride
- 122-01-0
4-chloro-benzoyl chloride
- 108-10-1
4-methyl-2-pentanone
- 41859-67-0
bezafibrate
| Conditions | Yield |
|---|---|
| With potassium hydroxide; sodium hydroxide; sulfuric acid; nitrogen; sodium hydrogencarbonate; potassium carbonate In water |
- 67-66-3
chloroform
- 41859-57-8
4-chloro-N-(4-hydroxyphenethyl)benzamide
- 67-64-1
acetone
- 41859-67-0
bezafibrate
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water at 50 - 60℃; for 1.5h; |
- 60-19-5
tyramine hydrochloride
- 41859-67-0
bezafibrate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: sodium hydroxide; sodium hydrogencarbonate / water / 3 h / 10 - 15 °C 2: sodium hydroxide / water / 1.5 h / 50 - 60 °C View Scheme | |
| Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water / 0 - 20 °C / Inert atmosphere 2: sodium hydroxide / chloroform / 65 °C / Inert atmosphere View Scheme |
- 122-01-0
4-chloro-benzoyl chloride
- 41859-67-0
bezafibrate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: sodium hydroxide; sodium hydrogencarbonate / water / 3 h / 10 - 15 °C 2: sodium hydroxide / water / 1.5 h / 50 - 60 °C View Scheme | |
| Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water / 3 h / 10 - 15 °C 2: sodium hydroxide / water / 1.5 h / 50 - 60 °C View Scheme | |
| Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water / 0 - 20 °C / Inert atmosphere 2: sodium hydroxide / chloroform / 65 °C / Inert atmosphere View Scheme |
| Conditions | Yield |
|---|---|
| With sodium hydroxide In chloroform at 65℃; Inert atmosphere; |
- 847682-00-2
1,3-bis(2,2-dimethyl-1,3-dioxan-5-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate
- 41859-67-0
bezafibrate
- 1043468-91-2
1,3-bis(2,2-dimethyl-1,3-dioxan-5-yloxy)propan-2-yl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate
| Conditions | Yield |
|---|---|
| With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1.5h; Inert atmosphere; | 98% |
- 41859-67-0
bezafibrate
- 74-88-4
methyl iodide
| Conditions | Yield |
|---|---|
| With potassium carbonate at 0 - 20℃; for 16h; | 96% |
- 41859-67-0
bezafibrate
- 765-30-0
Cyclopropylamine
| Conditions | Yield |
|---|---|
| Stage #1: bezafibrate With 1,1'-carbonyldiimidazole In dichloromethane for 1h; Stage #2: Cyclopropylamine In dichloromethane at 20℃; for 2h; | 96% |
| Conditions | Yield |
|---|---|
| With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 48h; Inert atmosphere; | 90% |
| With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 48h; Inert atmosphere; Glovebox; | 90% |
| Conditions | Yield |
|---|---|
| Stage #1: bezafibrate With N,N,N',N'-tetramethylguanidine In N,N-dimethyl acetamide at -5℃; for 0.333333h; Inert atmosphere; Stage #2: 1-iodoethyl isopropyl carbonate In N,N-dimethyl acetamide at -5℃; for 0.5h; Inert atmosphere; | 88% |
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Chemistry
IUPAC: 2-[4-[2-[(4-Chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid
Molecular Formula: C19H20ClNO4
Molecular Weight: 361.82
EINECS: 255-567-9
Density: 1.26 g/cm3
Melting Point: 184 ºC
Boiling Point: 572.1 °C at 760 mmHg
Flash Point: 299.8 °C
Solubility: soluble in DMF
Freely Rotating Bonds: 7
Polar Surface Area: 55.84 Å2
Index of Refraction: 1.583
Molar Refractivity: 95.99 cm3
Molar Volume: 287.1 cm3
Polarizability: 38.05 ×10-24 cm3
Surface Tension: 49.3 dyne/cm
Enthalpy of Vaporization: 90.23 kJ/mol
Vapour Pressure: 6.29E-14 mmHg at 25°C
The Cas Register Number of Bezafibrate is 41859-67-0.The chemical synonyms of Bezafibrate (CAS NO.41859-67-0) are 2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid ; 2-[4-(2-[4-Chlorobenzamido]ethyl)-phenoxyl]-2-methylpropanoic acid ; 2-[4-(2-[4-Chlorobenzomido]ethyl)-phenoxy]-2-methylpropanoic acid ; 2-(4-(2-((4-Chlorobenzoyl)amino)ethyl)phenoxy)-2-methylpropionic acid ; Aurora ka-851 ; Bezafibrate ; Bezalip ; Cedur .Product categories of Bezafibrate (CAS NO.41859-67-0) are Active pharmaceutical ingredients ; Intermediates and Fine Chemicals ; Pharmaceuticals ; Intracellular receptor .The molecular structure of Bezafibrate (CAS NO.41859-67-0) is
.
History
Boehringer Mannheim first introduced Bezafibrate in 1977.
Uses
Bezafibrate (CAS NO.41859-67-0) is used as pharmaceutical ingredient ; pharmaceuticals and antilipemic.It is used for used for the treatment of hyperlipidaemia.
Safety Profile
Hazard Codes: 
Xn
Risk Statements 22
R22: Harmful if swallowed.
Safety Statements 36
S36: Wear suitable protective clothing.
WGK Germany 1
RTECS UE8755000
Specification
Bezafibrate (CAS NO.41859-67-0) is one of the popular medicines available in today's medical field, which is very much effective against various diseases that affect human body. This medicine is one of the fast effective drugs included under the category, fibrate drug using in the medical field for treating the disease of hyperlipidaemia. Lowering the triglyceride and LDL cholesterol level in human blood and increasing the HDL level is the main functioning of this medicine. Boehringer Mannheim introduced the Bezafibrate - Canadian drug in the year 1977 as a valuable contribution to the medical field.