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| CAS No.: | 50-03-3 |
|---|---|
| Name: | Hydrocortisone acetate |
| Molecular Structure: | |
|
|
|
| Formula: | C23H32O6 |
| Molecular Weight: | 404.503 |
| Synonyms: | Cortacream;Cortaid;Cortef acetate;Cortell;Corticaine;Cortifoam;Cortril acetate;Cortril acetate AS;Efcolin;HA;Hc 45;Hycortole acetate;Hydrocort acetate;Hydrocortisat;Hydrocortisone 21-acetate;Cortisolacetate (6CI);Cortisol, 21-acetate (7CI,8CI);11b,17a,21-Trihydroxypregn-4-ene-3,20-dione21-acetate;17-Hydroxycorticosterone 21-acetate;17a-Hydroxycorticosterone acetate;21-Acetoxy-11b,17-dihydroxypregn-4-en-3,20-dione;21-Acetoxy-11b,17-dihydroxypregn-4-ene-3,20-dione;21-Acetoxy-11b,17a-dihydroxypregn-4-ene-3,20-dione;Abbocort;Anusol HC;Bambicort;Berlison F;Biocortar;CaldeCort;Chemysone;Colifoam;Colofoam;Cordes; |
| EINECS: | 200-004-4 |
| Density: | 1.26 g/cm/3 |
| Melting Point: | 223 °C (dec.)(lit.) |
| Boiling Point: | 576.6 °C at 760 mmHg |
| Flash Point: | 196.2 °C |
| Solubility: | Insoluble in water. |
| Appearance: | white powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 63 |
| Safety: | 36/37 |
| PSA: | 100.90000 |
| LogP: | 2.35240 |
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| Conditions | Yield |
|---|---|
| With pyridine at 20℃; | 100% |
| With pyridine at 0 - 25℃; for 24h; | 99% |
| With pyridine at 0 - 20℃; | 91% |
| Conditions | Yield |
|---|---|
| With Candida antarctica lipase B In ethyl acetate at 55℃; regioselective reaction; | 92% |
- 21940-45-4
Δ6-hydrocortisone-21-acetate
A
- 50-03-3
hydrocortisone acetate
| Conditions | Yield |
|---|---|
| With hydrogen; Pd/SrCO3 In ethyl acetate for 0.333333h; atmospheric pressure; | A 42% B 19% |
| Conditions | Yield |
|---|---|
| With acetone |
- 31085-34-4
21-acetoxy-11β-hydroxy-pregna-4,17(20)c-dien-3-one
- 50-03-3
hydrocortisone acetate
| Conditions | Yield |
|---|---|
| With osmium(VIII) oxide; [bis(acetoxy)iodo]benzene | |
| With osmium(VIII) oxide; triethylamine N-oxide; dihydrogen peroxide |
- 114160-28-0
4β-chloro-17-hydroxy-5β-pregnane-3,11,20-trione
- 50-03-3
hydrocortisone acetate
| Conditions | Yield |
|---|---|
| ueber mehrere Stufen; |
- 119180-68-6
21-acetoxy-11β-hydroxy-pregna-4,17(20)t-dien-3-one
- 50-03-3
hydrocortisone acetate
| Conditions | Yield |
|---|---|
| With osmium(VIII) oxide; [bis(acetoxy)iodo]benzene | |
| With osmium(VIII) oxide; triethylamine N-oxide; dihydrogen peroxide |
- 64313-94-6
RU 18760
- 50-03-3
hydrocortisone acetate
| Conditions | Yield |
|---|---|
| With bromine dann mit Semicarbazid und anschliessend mit Brenztraubensaeure; |
| Conditions | Yield |
|---|---|
| With Candida antarctica lipase B In tetrahydrofuran at 45℃; for 4h; Yield given; |
- 102213-14-9
22-acetoxy-11β-hydroxy-3-oxo-23,24-dinor-5β-chol-17(20)ξ-ene-21-nitrile
- 50-03-3
hydrocortisone acetate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: OsO4 2: bromine / dann mit Semicarbazid und anschliessend mit Brenztraubensaeure View Scheme |
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Specification
1. Introduction of Hydrocortisone acetate
Hydrocortisone acetate is one kind of white powder. The IUPAC Name of this chemical is [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate. Besides, Hydrocortisone acetate stability is stable, but may be light or moisture sensitive. It is incompatible with strong oxidizing agents. Hydrocortisone acetate belongs to Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Veterinaries;Steroid and Hormone.
The Classification Code of this chemical is Anti-Inflammatory Agents; Drug / Therapeutic Agent; Glucocorticoid; Mutation data; Reproductive Effect.
2. Properties of Hydrocortisone acetate
Physical properties about Hydrocortisone acetate are:
(1)Nominal Mass: 404 Da; (2)Average Mass: 404.4966 Da; (3)Monoisotopic Mass: 404.219889 Da; (4)Index of Refraction: 1.572; (5)Molar Refractivity: 105.15 cm3; (6)Molar Volume: 319.2 cm3; (7)Surface Tension: 54.6 dyne/cm; (8)Density: 1.26 g/cm3; (9)Flash Point: 196.2 °C; (10)Enthalpy of Vaporization: 99.14 kJ/mol; (11)Boiling Point: 576.6 °C at 760 mmHg; (12)Vapour Pressure: 1.08E-15 mmHg at 25°C; (13)Storage temp: 0-6°C; (14)Decomposition: 223°C.
3. Structure Descriptors of Hydrocortisone acetate
(1)InChI: InChI=1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
(2)InChIKey: InChIKey=ALEXXDVDDISNDU-JZYPGELDSA-N
(3)Smiles: C1[C@@]2([C@H]([C@H]3[C@H]([C@@]4(C(=CC(=O)CC4)CC3)C)[C@H]1O)CC[C@@]2(C(COC(C)=O)=O)O)C
4. Toxicity of Hydrocortisone acetate
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 2300mg/kg (2300mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LD50 | subcutaneous | 45050ug/kg (45.05mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
| rat | LDLo | subcutaneous | 250mg/kg (250mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 2102, 1977. |
RTECS : GM8960000
5. Safety information of Hydrocortisone acetate
Hazard Codes: 
Xn
Risk Statements: 63
R63: Possible risk of harm to the unborn child
Safety Statements: 36/37
S36/37: Wear suitable protective clothing and gloves
WGK Germany: 3
6. Uses of Hydrocortisone acetate
Hydrocortisone acetate can be used for biochemical research. As a sugar cortical hormone drug, it can anti-inflammatory, anti-allergic, antitoxin, resistance to shock action.
7. Production of Hydrocortisone acetate
Hydrocortisone and Acetic anhydride esterification under the condition of Azabenzene can be used to manufacture Hydrocortisone acetate.