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| CAS No.: | 57-85-2 |
|---|---|
| Name: | Testosterone propionate |
| Molecular Structure: | |
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| Formula: | C22H32O3 |
| Molecular Weight: | 344.494 |
| Synonyms: | Testosterone,propionate (8CI);17b-(Propionyloxy)androst-4-en-3-one;Agovirin;Androlon;Bio-testiculina;Enarmon;Enarmon-oil;Homandren;Hormoteston;Masenate;Nasdol;Orchisterone;Orchistin;Oreton;Pantestin;Primotestone;Propiokan;Sterandryl;Synerone;TP;Telipex;Testaform;Testex;Testonique;Testosid;Testosterone-17-propionate;Testrex;Testosterone Propionate;17-(1-oxopropoxy)-(17b)-androst-4-en-3-one; |
| EINECS: | 200-351-1 |
| Density: | 1.1 g/cm3 |
| Melting Point: | 118-123 °C |
| Boiling Point: | 454.6 °C at 760 mmHg |
| Flash Point: | 196.3 °C |
| Solubility: | <0.1 g/100 mL at 24.5 °C in water |
| Appearance: | white or yellowish-white crystals or a white or creamy-white crystalline powder |
| Hazard Symbols: |
 T
|
| Risk Codes: | 45-22-63 |
| Safety: | 53-36/37-45 |
| Transport Information: | UN 2811 |
| PSA: | 43.37000 |
| LogP: | 4.84010 |
propionyl chloride
3,3-(ethylenedioxy)-5-androsten-17β-ol
testosterone propionate
| Conditions | Yield |
|---|---|
| Stage #1: propionyl chloride; 3,3-(ethylenedioxy)-5-androsten-17β-ol With pyridine; dmap In 1,2-dichloro-ethane at 30℃; Inert atmosphere; Stage #2: With hydrogenchloride In water | 97.4% |
| Conditions | Yield |
|---|---|
| Stage #1: propionic acid; 17β-hydroxy-3-methoxyandrosta-3,5-diene With diisopropyl-carbodiimide In dichloromethane at 5℃; Inert atmosphere; Stage #2: With hydrogenchloride In water | 97.36% |
testosterone propionate
| Conditions | Yield |
|---|---|
| With 1,1'-bis(trimethylsilyl)-1,1',4,4'-tetrahydro-4,4'-bipyridylidene In acetonitrile at 20℃; for 2h; Inert atmosphere; | 89% |
| Conditions | Yield |
|---|---|
| With pyridine In N,N-dimethyl acetamide at 0 - 20℃; for 5h; Inert atmosphere; | 73% |
| With immobilized p-toluenesulfonic acid polymer bound macroporous In neat (no solvent) at 100℃; for 0.0416667h; Microwave irradiation; Sealed tube; Green chemistry; | 65% |
| With pyridine; diethyl ether | |
| With pyridine; dmap In dichloromethane at 5℃; Inert atmosphere; | 10.2 g |
| Conditions | Yield |
|---|---|
| With chromium(VI) oxide; acetic acid | |
| With chromium(VI) oxide; acetic acid |
3-acetoxy-17β-(1-oxopropoxy)-androsta-3,5-diene
testosterone propionate
| Conditions | Yield |
|---|---|
| With ethanol; potassium carbonate |
17β-propionyloxy-androst-5-en-3β-ol
testosterone propionate
| Conditions | Yield |
|---|---|
| With bromine; acetic acid nachfolgendes Behandeln mit CrO3 in wss.Essigsaeure und Erwaermen der Reaktionsloesung mit Zink-Pulver und Essigsaeure; | |
| With copper at 225℃; unter vermindertem Druck; |
| Conditions | Yield |
|---|---|
| With pyridine at 125℃; | |
| With pyridine at 25℃; | |
| Stage #1: testosterone With pyridine at 80℃; for 0.5h; Stage #2: propionic acid anhydride With dmap at 25℃; for 3.75h; | 166.5 g |
testosterone propionate
| Conditions | Yield |
|---|---|
| With bromine kurzes Erhitzen des erhaltenen 2α-Brom-17β-propionyloxy-5α-androstanons-(3) mit Pyridin auf Siedetemperatur und Erhitzen des Reaktionsprodukts unter 12 Torr bis auf 400grad; |
testosterone propionate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: acetone; aluminium isobutylate; benzene 2: pyridine / 25 °C View Scheme |
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The Testosterone Propionate, with the cas registry number 57-85-2, has its systematic name of (17beta)-3-oxoandrost-4-en-17-yl propanoate. This is a kind of white solid and is insoluble in water, and it belongs to the product categories of steroids. As to its usage, it is usually applied for curing breast cancer, oophoroma, myoma of uterus, Huppert's [Kahler's] disease, kidney cancer and so on.
The characteristics of this chemical are as following: (1)ACD/LogP: 4.90 ; (2)ACD/LogD (pH 5.5): 4.9; (3)ACD/LogD (pH 7.4): 4.9; (4)ACD/BCF (pH 5.5): 3132.11; (5)ACD/BCF (pH 7.4): 3132.11; (6)ACD/KOC (pH 5.5): 11064.07; (7)ACD/KOC (pH 7.4): 11064.07; (8)#H bond acceptors: 3 ; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 43.37; (11)Index of Refraction: 1.537; (12)Molar Refractivity: 97.32 cm3; (13)Molar Volume: 311.2 cm3; (14)Polarizability: 38.58 ×10-24 cm3; (15)Surface Tension: 42 dyne/cm; (16)Density: 1.1 g/cm3; (17)Flash Point: 196.3 °C; (18)Enthalpy of Vaporization: 71.42 kJ/mol; (19)Boiling Point: 454.6 °C at 760 mmHg; (20)Vapour Pressure: 1.89E-08 mmHg at 25°C; (21)Tautomer Count: 5 ; (22)Exact Mass: 344.235145 ; (23)MonoIsotopic Mass: 344.235145 ; (24)Topological Polar Surface Area: 43.4 ; (25)Heavy Atom Count: 25.
When you deal with this chemical, you should be very cautious. For as a kind of toxic chemical, it may at low levels cause damage to health, and even could cause cancer. If swallowed, it is very harmful; Besides, it has possible risk of harm to the unborn child. Therefore, you should take the following instructions. Wear suitable protective clothing and gloves, and avoid exposure - obtain special instructions before use. If in case of accident or if you feel unwell seek medical advice immediately (show the label where possible).
In addition, you could convert the following datas into the molecular structure：
(1)SMILES:O=C4\C=C2/[C@]([C@H]1CC[C@@]3([C@@H](OC(=O)CC)CC[C@H]3[C@@H]1CC2)C)(C)CC4
(2)InChI:InChI=1/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1
Below are the toxicity information of this chemical:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 970mg/kg (970mg/kg) | Drugs in Japan Vol. 6, Pg. 487, 1982. | |
| mouse | LD50 | oral | 1350mg/kg (1350mg/kg) | Drugs in Japan Vol. 6, Pg. 487, 1982. | |
| mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. 487, 1982. | |
| rat | LD50 | intraperitoneal | 585mg/kg (585mg/kg) | Drugs in Japan Vol. 6, Pg. 487, 1982. | |
| rat | LD50 | oral | 1gm/kg (1000mg/kg) | Drugs in Japan Vol. 6, Pg. 487, 1982. | |
| rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. 487, 1982. |
