CAS No.702-82-9,3-Amino-1-hydroxyadamantane Suppliers

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Basic Information

Molecular Structure:
CAS No.:	702-82-9
Name:	3-Amino-1-hydroxyadamantane
Article Data:	34

Formula:	C₁₀H₁₇NO
Molecular Weight:	167.251
Synonyms:	1-Adamantanol,3-amino- (7CI,8CI);(3-Hydroxyadamantan-1-yl)amine;1-Amino-3-adamantanol;1-Amino-3-hydroxyadamantane;3-Aminoadamantan-1-ol;
EINECS:	615-098-6
Density:	1.252 g/cm³
Melting Point:	265 °C (dec.)(lit.)
Boiling Point:	266.8 °C at 760 mmHg
Flash Point:	115.2 °C
Solubility:	Soluble in organic solvents,insoluble in water
Appearance:	slight yellow or white powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
PSA:	46.25000
LogP:	1.72910

Synthetic route

: 67496-92-8
3-nitroadamantan-1-ol

: 702-82-9
3-aminoadamantan-1-ol

Conditions

Conditions	Yield
	95%

: 665-66-7
amantadine hydrochloride

: 702-82-9
3-aminoadamantan-1-ol

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 10 - 15℃;	90%
With sulfuric acid; nitric acid at 0 - 10℃; for 2h;	81%
Stage #1: amantadine hydrochloride With sulfuric acid; nitric acid at 0 - 20℃; Inert atmosphere; Stage #2: With sodium hydroxide In water	72%

: 768-94-5
1-Adamantanamine

: 702-82-9
3-aminoadamantan-1-ol

Conditions

Conditions	Yield
Stage #1: 1-Adamantanamine With sulfuric acid; nitric acid In water at 5 - 25℃; Stage #2: With water; sodium hydroxide at 0 - 40℃; for 1h;	90%
With sulfuric acid; nitric acid at 0 - 10℃; for 2h;	81%
With Bromotrichloromethane; water; molybdenum hexacarbonyl at 150℃; for 6h; Inert atmosphere; regioselective reaction;	80%
With sulfuric acid; nitric acid at 90℃; Temperature;

: 778-10-9
N-(3-hydroxyadamantan-1-yl)acetamide

: 702-82-9
3-aminoadamantan-1-ol

Conditions

Conditions	Yield
With isopropyl alcohol; sodium hydroxide at 160℃; for 6h; Temperature; Reagent/catalyst; Autoclave; Inert atmosphere;	90%

: 880-52-4
N-(1-adamantyl)acetamide

A: 5001-18-3
1,3-adamantandiol

B: 702-82-9
3-aminoadamantan-1-ol

C: 778-10-9
N-(3-hydroxyadamantan-1-yl)acetamide

Conditions

Conditions	Yield
Stage #1: N-(1-adamantyl)acetamide With nitric acid Stage #2: With acetic acid; urea In water	A 11% B n/a C 13%

...Expand

: C10H17N*BF4(1-)*H(1+)

: 702-82-9
3-aminoadamantan-1-ol

Conditions

Conditions	Yield
With methyltrifluoromethyldioxirane; sodium carbonate 1.) CH3CN, CH2Cl2, 0 deg C, 3 h, 2.) CH2Cl2, RT, 5 h; Yield given. Multistep reaction;

: 3-methylenebicyclo<3.3.1>nonan-7-one

: 702-82-9
3-aminoadamantan-1-ol

Conditions

Conditions	Yield
With ammonium hydroxide at 130℃;

: 665-66-7
amantadine hydrochloride

A 3-hydroxytricyclo[3.3.1.13.7 ]decan-1-amine: 3-hydroxytricyclo[3.3.1.13.7 ]decan-1-amine

B: 702-82-9
3-aminoadamantan-1-ol

Conditions

Conditions	Yield
With sodium hydroxide

: 243145-00-8
3-nitro-1-amantadine

: 702-82-9
3-aminoadamantan-1-ol

Conditions

Conditions	Yield
With sodium methylate In methanol at 30℃; for 0.5h; pH=> 14; Solvent; Reagent/catalyst;	19.5g
With water; sodium hydroxide at 80℃; for 1.5h; pH=11 - 14; Temperature; pH-value;	150.6 g

: 768-95-6
1-adamanthanol

: 702-82-9
3-aminoadamantan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 9,10-diphenylanthracene; tetrabutyl-ammonium chloride; methanol; cerium(III) chloride / acetonitrile / 1.1 h / 30 °C / Irradiation; Flow reactor; Inert atmosphere 2: dichloromethane / 2 h / 20 °C 3: hydrogen / methanol / 12 h / 20 °C View Scheme

Raw Materials

768-94-5

665-66-7

Downstream Products

274901-16-5

Total:242 Page 1 of 7 1 2 3 4 5 6 …7 Next>>

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Specification

3-amino-1-adamantanol, with the CAS NO.702-82-9, has the Synonyms of TRICYCLO[3.3.1.13,7]DECAN-1-OL, 3-AMINO-; CHEMBRDG-BB 4003530; 3-AMINO-1-ADAMANTANOL; 3-Amino-1-hydroxyadamantane; 3-AMINOADAMANTAN-1-OL; AKOS BB-9784; 1-AMINO-3-ADAMANTANOL; 1-AMINO-3-HYDROXYADAMANTANE. It belongs to the Product Categories of Heterocycles series;Alcohols and Derivatives;Amines and Anilines;Adamantane derivatives;Amines;Adamantanes;Fused Ring Systems;Amino Alcohols;Organic Building Blocks;Oxygen Compounds.

Physical properties about 3-amino-1-adamantanol are: (1)ACD/LogP: 0.459; (2)ACD/LogD (pH 5.5): -2.64; (3)ACD/LogD (pH 7.4): -2.29; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 2; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 2; (11)Index of Refraction: 1.624; (12)Molar Refractivity: 47.167 cm³; (13)Molar Volume: 133.523 cm³; (14)Polarizability: 18.699 10-24cm³; (15)Surface Tension: 66.0400009155273 dyne/cm; (16)Density: 1.253 g/cm³; (17)Flash Point: 115.171 °C; (18)Enthalpy of Vaporization: 58.62 kJ/mol; (19)Boiling Point: 266.823 °C at 760 mmHg; (20)Vapour Pressure: 0.00100000004749745 mmHg at 25°C

You can still convert the following datas into molecular structure:
(1)SMILES:C1C2CC3(CC1CC(C2)(C3)O)N;
(2)Std. InChI:InChI=1S/C10H17NO/c11-9-2-7-1-8(3-9)5-10(12,4-7)6-9/h7-8,12H,1-6,11H2/t7-,8+,9+,10-;
(3)Std. InChIKey:DWPIPTNBOVJYAD-FIRGSJFUSA-N;