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CAS No.: | 58-18-4 |
---|---|
Name: | 17-Methyltestosterone |
Article Data: | 57 |
Molecular Structure: | |
Formula: | C20H30O2 |
Molecular Weight: | 302.457 |
Synonyms: | Androst-4-en-3-one,17b-hydroxy-17-methyl- (8CI);17a-Methyl-17b-hydroxyandrost-4-en-3-one;17a-Methyl-3-oxo-4-androsten-17b-ol;17a-Methyltestosterone;17b-Hydroxy-17a-methylandrost-4-ene-3-one;Android;Androsan;Androst-4-ene-17a-methyl-17b-ol-3-one;CDB 110;Glosso-Sterandryl;Homandren;Mesterone;Metandren;Oreton Methyl;Perandren;Steronyl;Synandrotabs;Testora;Testoviron (tablet);Testred; |
EINECS: | 200-366-3 |
Density: | 1.1 g/cm3 |
Melting Point: | 162-168 °C(lit.) |
Boiling Point: | 434.4 °C at 760 mmHg |
Flash Point: | 185.3 °C |
Solubility: | water: ≤0.5 mg/mL |
Appearance: | white to slightly yellowish-white crystalline |
Hazard Symbols: | T,Xn,Xi,F |
Risk Codes: | 45-63-22-20-19-11-61-60-36/37/38 |
Safety: | 53-36/37-45-24/25-22 |
PSA: | 37.30000 |
LogP: | 4.26930 |
(8R,9S,10R,13S,14S,17S)-10,13,17-Trimethyl-17-(tetrahydro-furan-2-yloxy)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
17-methyltestosterone
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In ethanol for 1h; Ambient temperature; | 100% |
Conditions | Yield |
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With <(C4Ph4COHOCC4Ph4)(μ-H)><(CO)4Ru2>; acetone at 56℃; for 18h; | 93% |
With chromium(VI) oxide; bromine; acetic acid Behandeln des Reaktionsprodukts mit CrCl2 in wss.Methanol unter Kohlendioxyd; | |
With aluminum tri-tert-butoxide; acetone; benzene |
17-methyltestosterone
Conditions | Yield |
---|---|
With hydrogenchloride In water; toluene at 60 - 65℃; Solvent; Reagent/catalyst; | 81.6% |
A
17-methyltestosterone
B
5α-17β-hydroxy-17α-methyl-Δ1-androsten-3-one
Conditions | Yield |
---|---|
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide at 65℃; for 24h; | A 10% B 74% |
With 1-n-butyl-3-methylimidazolim bromide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione at 65℃; for 22h; | A 10% B 74% |
Conditions | Yield |
---|---|
With thallium(III) nitrate trihydrate In diethylene glycol dimethyl ether for 24h; Ambient temperature; | 34% |
Conditions | Yield |
---|---|
Erhitzen des Reaktionsprodukts mit Kupfer-Spaenen unter vermindertem Druck auf 250-300grad; |
Conditions | Yield |
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With diethyl ether; toluene anschliessend Behandeln mit wss.NH4Cl und Behandeln des Reaktionsprodukts mit wss.Saeure; |
Conditions | Yield |
---|---|
With aluminum isopropoxide; toluene |
methylandrostenediol
cyclohexanone
aluminum isopropoxide
toluene
17-methyltestosterone
Conditions | Yield |
---|---|
With pyridine Erhitzen des Reaktionsprodukts mit Kupfer-Spaenen unter vermindertem Druck auf 250-300grad; | |
With pyridine Erhitzen des Reaktionsprodukts mit Kupfer-Spaenen unter vermindertem Druck auf 250-300grad; |
IUPAC Name: (8R,9S,10R,13S,14S,17S)-17-Hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Molecular Structure:
Molecular Formula : C20H30O2
Molecular Weight : 302.45
CAS NO: 58-18-4
EINECS : 200-366-3
Index of Refraction: 1.556
Surface Tension: 43.7 dyne/cm
Density: 1.1 g/cm3
Flash Point: 185.3 °C
Enthalpy of Vaporization: 79.71 kJ/mol
Boiling Point: 434.4 °C at 760 mmHg
Vapour Pressure: 2.28E-09 mmHg at 25 °C
Melting point 162-168 &dec;C
Alpha : 79 º (c=1, alcohol)
Storage temp: 2-8 °C
Solubility H2O: ≤0.5 mg/mL
Appearance: Methyltestosterone (CAS NO. 58-18-4) is white to slightly yellowish-white crystalline .
Classification Code of Methyltestosterone (CAS NO. 58-18-4): Anabolic Agents; Androgen; Antineoplastic Agents; Antineoplastic agents, hormonal; Drug / Therapeutic Agent; Hormone; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Human Data; Mutation data; Reproductive Effect; Tumor data
1.Methyltestosterone (CAS NO. 58-18-4) is used for androgen medicines, used for supplement treatment with testosterone deficiency .
2.Methyltestosterone (CAS NO. 58-18-4) can also be used for functional bleeding of uterine, aplastic anemia and other diseases treatment.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 39mg/kg/33W-I (39mg/kg) | LIVER: "JAUNDICE, CHOLESTATIC" | American Journal of Gastroenterology. Vol. 82, Pg. 461, 1987. |
mouse | LD50 | intraperitoneal | 400mg/kg (400mg/kg) | Drugs in Japan Vol. 6, Pg. 830, 1982. | |
mouse | LD50 | oral | 1860mg/kg (1860mg/kg) | Drugs in Japan Vol. 6, Pg. 830, 1982. | |
mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. 830, 1982. | |
rat | LD50 | intraperitoneal | 1050mg/kg (1050mg/kg) | Drugs in Japan Vol. 6, Pg. 830, 1982. | |
rat | LD50 | oral | 2500mg/kg (2500mg/kg) | Drugs in Japan Vol. 6, Pg. 830, 1982. | |
rat | LD50 | subcutaneous | 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. 830, 1982. |
Hazard Codes: T,Xn,Xi ,F
Risk Statements: 45-63-22-20-19-11-61-60-36/37/38
R45:May cause cancer.
R63:Possible risk of harm to the unborn child.
R22:Harmful if swallowed.
R20:Harmful by inhalation.
R19:May form explosive peroxides.
R11:Highly flammable.
R60:May impair fertility.
R61:May cause harm to the unborn child.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 53-36/37-45-24/25-22
S53:Avoid exposure - obtain special instructions before use.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S24/25:Avoid contact with skin and eyes.
S22:Do not breathe dust.
RIDADR: 3249
WGK Germany: 3
RTECS: BV8400000
HazardClass: 6.1(b)
PackingGroup: III
Methyltestosterone (CAS NO. 58-18-4), its Synonyms are (17-beta)-17-Hydroxy-17-methylandrost-4-en-3-one ; 17(alpha)-Methyl-delta4-androsten-17(beta)-ol-3-one ; 17-Hydroxy-17-methyl-3-keto-androstene-4 ; 17-beta-Hydroxy-17-methylandrost-4-en-3-one ; 17alpha-Methyl-3-oxo-4-androsten-17beta-ol ; 17alpha-Methyl-delta-androsten-17beta-ol-3-one ; M.T.Mucorettes ; Malestrone ; Androst-4-en-3-one, 17-beta-hydroxy-17-methyl- ; Androst-4-en-3-one, 17-hydroxy-17-methyl-, (17beta)- ; Androst-4-en-3-one, 17beta-hydroxy-17-methyl- .