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CAS No.: | 638-23-3 |
---|---|
Name: | Carbocistein |
Article Data: | 21 |
Molecular Structure: | |
Formula: | C5H9NO4S |
Molecular Weight: | 179.197 |
Synonyms: | Alanine,3-[(carboxymethyl)thio]-, L- (6CI,8CI);(2R)-2-Amino-3-[(carboxymethyl)thio]propionic acid;(L)-2-Amino-3-(carboxymethylthio)propionicacid;(R)-S-(Carboxymethyl)cysteine;3-[(Carboxymethyl)thio]-L-alanine;AHR3053;Bronchokod;Carbocysteine;Chilvax;L-(Carboxymethyl)cysteine;LJ 206;Lisil;Lisomucil;Loviscol;Muciclar;Mucocis;Mucodyne;Mucofan;Mucolase;Mucolex;Pectox;Pulmoclase;Reomucil;Rhinathiol;Rhinatiol;S-(Carboxymethyl)-(R)-cysteine;Siroxyl;Thiodril;Transbronchin;L-Carbocysteine(S-CMC); |
EINECS: | 211-327-5 |
Density: | 1.514 g/cm3 |
Melting Point: | 208-213 °C (dec.) |
Boiling Point: | 417.3 °C at 760 mmHg |
Flash Point: | 206.2 °C |
Solubility: | soluble in cold water |
Appearance: | white to slightly off-white amorphous powder |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 24/25-36-26 |
PSA: | 125.92000 |
LogP: | -0.08360 |
DL-cysteine hydrochloride
carbocisteine
Conditions | Yield |
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With Iodoacetic acid | 100% |
Conditions | Yield |
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With ammonia; sodium carbonate; sodium sulfite In water at 55℃; for 0.5h; pH=3 - 7.3; pH-value; Concentration; Reagent/catalyst; Temperature; | 96.7% |
Conditions | Yield |
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With ammonia; ammonium bicarbonate In water at 20 - 50℃; for 0.5h; pH=7.5; Reagent/catalyst; Temperature; pH-value; Large scale; | 96% |
Conditions | Yield |
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in schwach alkalischer oder neutraler wss. Loesung; | |
In water at 20℃; for 0.25h; |
Conditions | Yield |
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in schwach alkalischer oder neutraler wss. Loesung; |
Conditions | Yield |
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With sodium hydroxide; zinc at 30℃; | |
With sodium amide In ammonia | |
With ammonia; sodium |
sodium monochloroacetic acid
2-amino-(2)-thiazoline-4-carboxylic acid
carbocisteine
Conditions | Yield |
---|---|
at 26℃; for 8h; potassium phosphate buffer pH 8.0, Pseudomonas desmolitica AJ 11898; |
Conditions | Yield |
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With Tris-HCl buffer at 30℃; for 0.166667h; β-cyano-L-alanine synthase (from Spinacia oleracea, Chenopodiaceae); | |
With Tris-HCl buffer; β-cyano-L-alanine synthase (from Spinacea oleracea, Chenopodiaceae) at 30℃; for 0.166667h; |
Conditions | Yield |
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With potassium phosphate; pyridoxal 5'-phosphate In water at 37℃; for 24h; enzyme catalyst: S-carboxymethyl-L-cysteine synthase from Escherichia coli W3110; |
IUPAC Name: 2-Amino-3-(carboxymethylsulfanyl)propanoic acid
Carbocisteine's Molecular formula: C5H9NO4S
Carbocisteine's Molar mass: 179.195 g/mol
EINECS: 211-327-5
alpha: -31o (c=1, 10% NaH2CO3)
storage temp.: 2-8°C
Water Solubility of Carbocisteine (CAS NO.638-23-3): soluble in cold water
Synonyms: (l)-2-amino-3-(carboxymethylthio)propionicacid;(r)-s-(carboxymethyl)cysteine;carbocisteine;l.j.206;l-3-((carboxymethyl)thio)alanine;l-carboxymethylcysteine;rhinathiol;rinatiol
Index of Refraction: 1.588
Surface Tension: 78 dyne/cm
Melting point: 208-213 °C (dec.)
Density: 1.514 g/cm3
Flash Point: 206.2 °C
Enthalpy of Vaporization: 73.57 kJ/mol
Boiling Point: 417.3 °C at 760 mmHg
Vapour Pressure: 3.91E-08 mmHg at 25 °C
Appearance of Carbocisteine (CAS NO.638-23-3): white to slightly off-white amorphous powder
Carbocisteine (CAS NO.638-23-3) is an expectorant that can be used to help relieve the symptoms of Chronic Obstructive Pulmonary Disorder COPD and bronchiectasis by allowing the sufferer to bring up sputum more easily.
1. | ipr-rat LD50:7800 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),190. | ||
2. | scu-rat LD50:10,300 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),190. | ||
3. | orl-mus LD50:8400 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),190. | ||
4. | ipr-mus LD50:1433 mg/kg | YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. 94 (1974),1419. | ||
5. | scu-mus LD50:9 g/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),190. |
6. RTECS AY4342000
RTECS#: CAS# 638-23-3: AY4342000
LD50/LC50: RTECS:
CAS# 638-23-3: Oral, mouse: LD50 = 8400 mg/kg;
Oral, rat: LD50 = >15 gm/kg;
Carcinogenicity: S-Carboxymethyl-L-cysteine - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information.
Reported in EPA TSCA Inventory.
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
Hazard Codes: Xi
WGK Germany: 2
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials Strong oxidizing agents.
Hazardous Decomposition Products Carbon monoxide, carbon dioxide.
Hazardous Polymerization Hazardous Polymerization