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CAS No.: | 66774-02-5 |
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Name: | CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL |
Article Data: | 20 |
Molecular Structure: | |
Formula: | C19H15 Cl O |
Molecular Weight: | 294.78 |
Synonyms: | Methanol,(o-chlorophenyl)diphenyl- (6CI); (2-Chlorophenyl)diphenylmethanol; NSC 170882;TRAM 3; o-Chlorophenyldiphenylmethanol |
Density: | 1.216g/cm3 |
Melting Point: | 91-92 °C(Solv: acetic acid (64-19-7)) |
Boiling Point: | 447.6°C at 760 mmHg |
Flash Point: | 224.5°C |
PSA: | 20.23000 |
LogP: | 4.62420 |
clotrimazole
o-chlorotriphenylmethanol
Conditions | Yield |
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With hydrogenchloride for 2h; Heating; | 93% |
With hydrogenchloride; water for 3h; Heating / reflux; | 85% |
With hydrogenchloride In water; isopropyl alcohol for 17h; Heating; | 36% |
Conditions | Yield |
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With hydrogenchloride In water; acetonitrile at 80℃; for 2h; | A n/a B 71% |
(2-chlorophenyl)(phenyl)methanone
phenylmagnesium bromide
o-chlorotriphenylmethanol
Conditions | Yield |
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Stage #1: phenylmagnesium bromide With zinc(II) chloride In tetrahydrofuran at 20℃; for 1h; Stage #2: (2-chlorophenyl)(phenyl)methanone In tetrahydrofuran for 120h; Reflux; | 58% |
Conditions | Yield |
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With (trimethylsilyl)methylmagnesium chloride In tetrahydrofuran at 20℃; for 12h; | 32% |
Conditions | Yield |
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With diethyl ether |
Conditions | Yield |
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With diethyl ether |
Conditions | Yield |
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With diethyl ether |
diethyl ether
ethyl 2-chlorobenzoate
A
1,2-bis-(2-chloro-phenyl)-1,2-diphenyl-ethane-1,2-diol
B
o-chlorotriphenylmethanol
Conditions | Yield |
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at 50℃; |
1-chloro-2-(dichloro(phenyl)methyl)benzene
benzene
o-chlorotriphenylmethanol
Conditions | Yield |
---|---|
With aluminium trichloride at 20℃; for 22h; |
(2-chlorophenyl)(phenyl)methanone
o-chlorotriphenylmethanol
Conditions | Yield |
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Multi-step reaction with 2 steps 1: PCl5 / 2 h / 130 - 140 °C 2: AlCl3 / 22 h / 20 °C View Scheme | |
With phenyllithium In cyclohexane-Et2 O; diethyl ether | 23.1 g (78%) |