Products Categories
| CAS No.: | 69-52-3 |
|---|---|
| Name: | Ampicillin sodium |
| Molecular Structure: | |
|
|
|
| Formula: | C16H18N3NaO4S |
| Molecular Weight: | 371.392 |
| Synonyms: | Alpen-N;Amcill-S;Ampicillin natrium;Ampicillin sodium;Ampicillin sodium salt;Binotal sodium;Citteral;D(-)-alpha-Aminobenzylpenicillin sodium salt;Domicillin;Monosodium (2S,5R,6R)-6-((R)-2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate; |
| EINECS: | 200-708-1 |
| Melting Point: | 215 °C (dec.)(lit.) |
| Boiling Point: | 683.9 °C at 760 mmHg |
| Flash Point: | 367.4 °C |
| Solubility: | water: 50 mg/mL, clear, very faintly yellow |
| Appearance: | White powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 42/43 |
| Safety: | 22-36/37-45 |
| PSA: | 140.86000 |
| LogP: | 0.01250 |
- 81281-59-67-Benzylideneaminotheophylline
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 71825-51-92-methyl-2-(4-nitrophenyl)propanenitrile
- 71780-15-9
N-(1-methyl-2-ethoxycarbonylvinyl)ampicillin sodium
- 69-52-3
ampicillin sodium
| Conditions | Yield |
|---|---|
| With water at 25℃; Rate constant; hydrolysis at pH 7.4; |
- 69-52-3
ampicillin sodium
- 141-97-9
ethyl acetoacetate
- 71780-15-9
N-(1-methyl-2-ethoxycarbonylvinyl)ampicillin sodium
| Conditions | Yield |
|---|---|
| In isopropyl alcohol at 25℃; for 3h; | 75% |
What can I do for you?
Get Best Price
Consensus Reports
Specification
The Ampicillin sodium, with the CAS registry number 69-52-3 and EINECS registry number 200-708-1, has the systematic name of sodium (2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate. It is a kind of white powder, and the molecular formula of this chemical is C16H18N3NaO4S. As a semi-synthetic derivative of penicillin, it functions as an orally active broad-spectrum antibiotic. And it should be stored at 2-8°C.
The physical properties of Ampicillin sodium are as following: (1)ACD/LogP: 1.35; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 7; (4)#H bond donors: 4; (5)#Freely Rotating Bonds: 5; (6)Polar Surface Area: 106.46 Å2; (7)Flash Point: 367.4 °C; (8)Enthalpy of Vaporization: 105.36 kJ/mol; (9)Boiling Point: 683.9 °C at 760 mmHg; (10)Vapour Pressure: 1.21E-19 mmHg at 25°C.
Synthetic method and uses of Ampicillin sodium: It can be obtained by the salifing of penbritin: Add penbritin to the water, and adjust the pH to 9 by adding sodium hydroxide solution. Then you can get the product after a series of decoloration, filtration and drying. And because of its tericidal action, it is often used in the molecular biology and also used for tissue culture(to prevent microbial contamination).
You should be cautious while dealing with this chemical. It may cause sensitization by inhalation and skin contact. Therefore, you had better take the following instructions: Wear suitable protective clothing and gloves, and in case of accident or if you feel unwell, seek medical advice immediately (show label where possible); Do not breathe dust.
You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].O=C([O-])[C@@H]2N3C(=O)[C@@H](NC(=O)[C@@H](c1ccccc1)N)[C@H]3SC2(C)C
(2)InChI: InChI=1/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1
(3)InChIKey: KLOHDWPABZXLGI-IANBRGBNBB
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 5700mg/kg (5700mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| mouse | LD50 | oral | > 5314mg/kg (5314mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 18, Pg. 356, 1962. | |
| mouse | LD50 | subcutaneous | > 5314mg/kg (5314mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 18, Pg. 356, 1962. | |
| mouse | LDLo | intravenous | 2657mg/kg (2657mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | British Journal of Pharmacology and Chemotherapy. Vol. 18, Pg. 356, 1962. |
| rat | LD50 | intraperitoneal | 7400mg/kg (7400mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| rat | LD50 | oral | > 5314mg/kg (5314mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 18, Pg. 356, 1962. | |
| rat | LD50 | subcutaneous | > 5314mg/kg (5314mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 18, Pg. 356, 1962. | |
| women | TDLo | oral | 100mg/kg/5D (100mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES | Lancet. Vol. 2, Pg. 707, 1978. |