CAS No.71-00-1,Histidine Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	71-00-1
Name:	Histidine
Article Data:	194

Formula:	C₆H₉N₃O₂
Molecular Weight:	155.156
Synonyms:	(S)-alpha-amino-1H-Imidazole-4-propanoic acid;Histidinum [INN-Latin];alpha-Amino-4(or 5)-imidazolepropionic acid;(L)-Histidine;1H-Imidazole-4-alanine, (S)-;4-(2-Amino-2-carboxyethyl)imidazole;(S)-4-(2-Amino-2-carboxyethyl)imidazole;(2S)-2-azaniumyl-3-(3H-imidazol-4-yl)propanoate;Histidine (VAN);L-Alanine, 3-(1H-imidazol-4-yl)-;Glyoxaline-5-alanine;S-Histidine;alpha-amino-4-imidazoleproprionic acid;Histidine (USP);Istidina;L-Histidine (JAN);(S)-2-Amino-3-(4-imidazolyl)propionsaeure;L-Histidine Base;L-2-Amino-3-(4-imidazolyl)propionic acid;L-His-OH;L-Histidine;HIS;(S)-alpha-Amino-1H-imidazole-4-propionic acid;
EINECS:	200-745-3
Density:	1.423 g/cm³
Melting Point:	282 °C (dec.)(lit.)
Boiling Point:	458.9 °C at 760 mmHg
Flash Point:	231.3 °C
Solubility:	41.6 g/L (25 ºC)
Appearance:	white crystalline powder
Hazard Symbols:	Xn
Risk Codes:	22-36/37/38
Safety:	24/25-36/37-26-22
PSA:	92.00000
LogP:	0.06440

Synthetic route

: 83468-83-1
N(α)-t-butoxycarbonyl-N(ϖ)-benzyloxymethyl-L-histidine

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With Nafion H; dimethylsulfide; 3-methyl-phenol; trifluoroacetic acid for 3h;	100%
With trimethylsilyl trifluoromethanesulfonate; diphenyl sulfide In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed.;	90.2%

: 35899-43-5
Boc-His(Tos)-OH

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; diphenyl sulfide In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed.;	100%
With trifluoroacetic acid-thioanisole for 1h; Product distribution; various reagents;	16.7%

: 73475-63-5
H-His(MBS)-OH

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With sodium hydroxide at 23℃; for 1h; Product distribution; various reagents;	100%

: 111-26-2
hexan-1-amine

: 78641-69-7
(S)-2-(3,5-Dinitro-4-oxo-4H-pyridin-1-yl)-3-(1H-imidazol-4-yl)-propionic acid

A: 74197-48-1
1-hexyl-3,5-dinitro-4-pyridone

B: 71-00-1
L-histidine

Conditions

Conditions	Yield
In pyridine Product distribution;	A n/a B 92%

...Expand

: 17791-52-5
N-(tert-butoxycarbonyl)-L-histidine

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With tetradecyl(trihexyl)phosphonium bistriflamide; trifluoroacetic acid at 130℃; for 0.166667h; Ionic liquid;	92%

: C6H9N3O2*H3N*ClH

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With ruthenium nanoparticles dispersed in a polyvinylpyrrolidone matrix; amberlyst A-21 In methanol; dichloromethane	87%

: 2002-22-4
(2S)-2-amino-3-(2-mercapto-1H-imidazol-4-yl)propanoic acid

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With iron(III) sulfate In water at 95℃; for 1h;	85%

: C19H17N3O2

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With palladium In methanol; cyclohexane for 120h; Reflux;	84.5%

: 305-84-0
Carnosine

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With trans-[Co(3,2,3-tet)Cl2]Cl; water In water at 45℃; for 6h; pH=7.5;	75%

: 50-99-7
D-glucose

A: 56-41-7
L-alanin

B: 56-40-6
glycine

C: 71-00-1
L-histidine

Conditions

Conditions	Yield
With ammonium sulfate; ammonium hydroxide; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; (S)-2-[3]pyridyl-pyrrolidine-1-carboxylic acid amide; calcium (R)-pantothenate; Thiamine hydrochloride; magnesium sulfate; iron(II) sulfate; urea; calcium carbonate; sodium chloride; manganese(ll) chloride; biotin In water at 28℃; for 46h; Mechanism; fermentation with Corynebacterium glutamicum N-730; pH=7.4;	A n/a B n/a C 5%

Yield

With ammonium sulfate; ammonium hydroxide; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; (S)-2-[3]pyridyl-pyrrolidine-1-carboxylic acid amide; calcium (R)-pantothenate; Thiamine hydrochloride; magnesium sulfate; iron(II) sulfate; urea; calcium carbonate; sodium chloride; manganese(ll) chloride; biotin In water at 28℃; for 46h; Mechanism; fermentation with Corynebacterium glutamicum N-730; pH=7.4;

A n/a
B n/a
C 5%

...Expand

Raw Materials

10101-30-1

71-00-1

7647-01-0

111-26-2

305-84-0

14997-58-1

55258-11-2

3465-72-3

Downstream Products

645-35-2

57-13-6

Total:286 Page 1 of 8 1 2 3 4 5 6 …8 Next>>

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

1. Introduction of L-Histidine

L-Histidine, with the IUPAC Name: (2S)-2-Amino-3-(1H-imidazol-5-yl)propanoic acid, is one kind of white crystal powder. Histidine is used for food additives and raw materials of pharmaceutical .

2. Properties of L-Histidine

L-Histidine has the following datas: (1)Classification Code: Amino acid; Mutation data; (2)Melting point: 282 °C; (3)Index of Refraction: 1.614; (4)Molar Refractivity: 38.01 cm³; (5)Molar Volume: 108.9 cm³; (6)Surface Tension: 79.6 dyne/cm; (7)Density: 1.423 g/cm³; (8)Flash Point: 231.3 °C; (9)Enthalpy of Vaporization: 75.79 kJ/mol; (10)Boiling Point: 458.9 °C at 760 mmHg; (11)Vapour Pressure: 3.25E-09 mmHg at 25°C.

3. Structure Descriptors of L-Histidine

You could convert the following datas into the molecular structure:
InChI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChIKey: InChIKey=HNDVDQJCIGZPNO-YFKPBYRVSA-N
Smiles: c1(C[C@@H](C(O)=O)N)c[nH]cn1

4. Toxicity of L-Histidine

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	> 10gm/kg (10000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
mouse	LD50	intravenous	> 2gm/kg (2000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
mouse	LD50	oral	> 15gm/kg (15000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
mouse	LD50	subcutaneous	> 10gm/kg (10000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat	LD50	intraperitoneal	> 8gm/kg (8000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat	LD50	intravenous	> 2gm/kg (2000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat	LD50	oral	> 15gm/kg (15000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.

5. Safety Information of L-Histidine

Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Other safty informations about Histidine (CAS NO.71-00-1):
Hazard Codes: Harmful Xn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36/37-26-22
S24/25: Avoid contact with skin and eyes.
S36/37: Wear suitable protective clothing and gloves.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S22: Do not breathe dust.
WGK Germany: 2
RTECS: MS3070000
F: 10-23
HS Code: 29332990