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| CAS No.: | 7357-67-7 |
|---|---|
| Name: | N-(3-Chloropropyl)morpholine |
| Article Data: | 57 |
| Molecular Structure: | |
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|
|
| Formula: | C7H14ClNO |
| Molecular Weight: | 163.647 |
| Synonyms: | 1-Chloro-3-morpholinopropane;3-(Morpholin-4-yl)propyl chloride;3-Chloro-1-(morpholin-4-yl)propane;3-Morpholinopropyl chloride;4-(3-Chloropropyl)morpholine;Morpholine,4-(3-chloropropyl)-; |
| EINECS: | 461-510-0 |
| Density: | 1.062 g/cm3 |
| Melting Point: | NA |
| Boiling Point: | 227.1 °C at 760 mmHg |
| Flash Point: | 91.2 °C |
| Appearance: | Light Yellow to Colourless Liquid |
| Risk Codes: | 36/37/38 |
| Safety: | 26-36/37/39 |
| PSA: | 12.47000 |
| LogP: | 0.88540 |
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| Conditions | Yield |
|---|---|
| In toluene | 96% |
| In toluene for 2h; Reflux; | 96% |
| With zinc In tetrahydrofuran at 20℃; for 1h; | 95% |
| Conditions | Yield |
|---|---|
| With thionyl chloride In dichloromethane at 20℃; for 2h; | 96% |
| With thionyl chloride; chloroform | |
| With thionyl chloride |
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4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde
- 7357-67-7
4-(3-chloropropyl)morpholine
| Conditions | Yield |
|---|---|
| With nitric acid In water at 40 - 45℃; for 4.33333 - 4.5h; |
A
- 7357-67-7
4-(3-chloropropyl)morpholine
A
- 7357-67-7
4-(3-chloropropyl)morpholine
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morpholine
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pentaerythritol tetraacrylate
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1,3-chlorobromopropane
- 7357-67-7
4-(3-chloropropyl)morpholine
| Conditions | Yield |
|---|---|
| With sodium hydroxide In toluene |
- 7357-67-7
4-(3-chloropropyl)morpholine
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ethyl vanillate
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ethyl 3-methoxy-4-(3-morpholinopropoxy)benzoate
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 2h; | 100% |
| With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h; | 100% |
| With potassium carbonate In N-methyl-acetamide; diethyl ether | 100% |
| With potassium carbonate In N,N-dimethyl-formamide at 80℃; | 100% |
| Conditions | Yield |
|---|---|
| Stage #1: 4-(3-chloropropyl)morpholine; 1H-indole-5-sulfonamide With tetra-(n-butyl)ammonium iodide; sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 2h; Inert atmosphere; Stage #2: trifluoroacetic acid In methanol; water | 100% |
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile at 95℃; for 3h; Inert atmosphere; | 99.1% |
- 7357-67-7
4-(3-chloropropyl)morpholine
- 52805-46-6
2-methoxy-5-cyanophenol
- 675126-28-0
4-methoxy-3-[3-(morpholin-4-yl)propoxy]benzonitrile
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N-dimethyl-formamide at 85℃; for 10h; | 98% |
| With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 78℃; for 4h; | 96% |
| With potassium carbonate In N,N-dimethyl-formamide at 85℃; for 10h; | 95% |
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Chemistry
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IUPAC Name: 4-(3-Chloropropyl)morpholine
Molecular Formula: C7H14ClNO
Molecular Weight: 163.64 g/mol
SMILES: N1(CCCCl)CCOCC1
InChI: InChI=1/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2
Product Categories: Aromatic Morpholines; Benzomorpholines & Benzothiomorpholines; Methyl Halides;Morpholines & Thiomorpholines; API intermediates; Heterocycles; Intermediates; Intermediates & Fine Chemicals; Pharmaceuticals; Benzomorpholines & Benzothiomorpholines; Methyl Halides; Morpholines & Thiomorpholines
Index of Refraction: 1.463
Molar Refractivity: 42.42 cm3
Molar Volume: 154 cm3
Polarizability: 16.81×10-24 cm3
Surface Tension: 32 dyne/cm
Density: 1.062 g/cm3
Flash Point: 91.2 °C
Enthalpy of Vaporization: 46.37 kJ/mol
Boiling Point: 227.1 °C at 760 mmHg
Vapour Pressure of N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7): 0.0789 mmHg at 25 °C
Uses
N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7) is commonly used as gefitinib intermediate.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 104mg/kg (104mg/kg) | Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 33, Pg. 169, 1976. |
Safety Profile
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements of N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7): 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
Specification
N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7), its Synonyms are 1-Chloro-3-morpholinopropane ; 3-Morpholinopropyl chloride ; 4-(3-Chloropropyl)morpholine ; Morpholine, 4-(3-chloropropyl)- .